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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Guanine nucleotide binding protein-like 3

Nucleostemin, N-S
involved in controlling cell proliferation in stem cells and cancer cells [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: p53, CAN, POLYMERASE, Nanog, HAD
Papers on Nucleostemin
Nucleostemin promotes the proliferation of human glioma via Wnt/β-Catenin pathway.
Cui et al., Suzhou, China. In Neuropathology, Dec 2015
UNASSIGNED: Nucleostemin, nucleolar guanosine triphosphate (GTP)-binding protein 3, is a member of the MMR1/HSR1 GTP-binding protein family.
Nucleostemin exerts anti-apoptotic function via p53 signaling pathway in cardiomyocytes.
Liu et al., Nantong, China. In In Vitro Cell Dev Biol Anim, Nov 2015
One such regulatory protein named nucleostemin (NS) has vital roles in cardiac ischemia.
The nucleolar GTPase nucleostemin-like 1 plays a role in plant growth and senescence by modulating ribosome biogenesis.
Pai et al., Seoul, South Korea. In J Exp Bot, Oct 2015
Nucleostemin is a nucleolar GTP-binding protein that is involved in stem cell proliferation, embryonic development, and ribosome biogenesis in mammals.
[Identification of the Gene Encoding Nucleostemin in the Eye Tissues of Pleurodeles waltl].
Grigoryan et al., In Izv Akad Nauk Ser Biol, Sep 2015
Sequencing showed that these nucleotide sequences belong to the Ns gene of the newt P. walt, which encodes the nucleolar protein nucleostemin.
Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
Okuda et al., Saitama, Japan. In Stem Cells, Apr 2015
Nucleostemin (NS) is a nucleolar GTP-binding protein that is involved in a plethora of functions including ribosomal biogenesis and maintenance of telomere integrity.
Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging.
Sussman et al., Roma, Italy. In J Am Coll Cardiol, Feb 2015
Nucleostemin (NS) is a nucleolar protein regulating stem cell proliferation and pluripotency.
Nucleostemin Knockdown Sensitizes Hepatocellular Carcinoma Cells to Ultraviolet and Serum Starvation-Induced Apoptosis.
Tong et al., Beijing, China. In Plos One, 2014
Nucleostemin (NS) is a GTP-binding protein that is predominantly expressed in embryonic and adult stem cells but not in terminally differentiated cells.
Upregulation of nucleostemin in colorectal cancer and its effects on cell malignancy.
Zhong et al., Nanning, China. In Onco Targets Ther, 2014
OBJECTIVE: Nucleostemin (NS) is a new protein localized in the nucleolus of most stem cells and tumor cells, which regulates their self-renewal and cell cycle progression.
Nucleostemin- and Oct 3/4-positive stem/progenitor cells exhibit disparate anatomical and temporal expression during rat Achilles tendon healing.
Eriksson et al., Göteborg, Sweden. In Bmc Musculoskelet Disord, 2014
Tendons were harvested at one, two, eight and 17 weeks post-rupture and stained with antibodies specific to stem/progenitor cells (Octamer-binding transcription factor 3/4 (Oct 3/4) and nucleostemin), migrating cells (Dynamin 2 (Dyn 2)) and leukocytes (CD45).
Nucleostemin regulates proliferation and migration of gastric cancer and correlates with its malignancy.
Wu et al., Wuhan, China. In Int J Clin Exp Med, 2014
OBJECTIVE: The aim of this study was to investigate the effects of nucleostemin (NS) knocking down in SGC- 7901 gastric cancer cell line and investigates its correlation with the metastasis and TNM stage ingastric cancer (GC) patients.
FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth.
Schlaepfer et al., San Diego, United States. In Breast Cancer Res, 2014
Nucleostemin (NS), a nucleolar-localized protein, modulates cell cycle progression, stemness, and three-dimensional tumor spheroid formation.
Knockdown of nucleostemin can inhibit the proliferation of esophageal carcinoma cells in vitro through upregulating p21.
Fang et al., In Hepatogastroenterology, 2014
Nucleostemin is a nucleolar protein expressed in stem and cancer cells, involved in the regulation of cell proliferation.
Characterization of the murine myeloid precursor cell line MuMac-E8.
Lehmann et al., Leipzig, Germany. In Plos One, 2013
It could be shown that MuMac-E8 cells express mRNA of some genes associated with pluripotent stem cells (Nanog, Nucleostemin), of genes for hematopoietic markers (EPCR, Sca-1, CD11b, CD45), for the mesenchymal marker CD105 and of genes for the neural markers Pax-6 and Ezrin.
Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency.
Marine et al., Gent, Belgium. In Oncogene, 2012
NS functions downstream of Myc as a rate-limiting regulator of cell proliferation and transformation.
Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency.
Bishop et al., San Francisco, United States. In J Cell Biol, 2012
Nucleostemin in the maintenance of ESC self-renewal, demonstrate the importance of rapid transit through G1 for this process, and expand the known classes of reprogramming factors.
Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1.
Tsai et al., Houston, United States. In J Cell Biol, 2012
The nucleostemin(NS)could promote the recruitment of PML-IV to SUMOylated TRF1 in TA( ) and ALT cells.
Ubiquitin- and MDM2 E3 ligase-independent proteasomal turnover of nucleostemin in response to GTP depletion.
Lu et al., New Orleans, United States. In J Biol Chem, 2012
NS undergoes a ubiquitin- and MDM2-independent proteasomal degradation when intracellular GTP levels are markedly reduced
An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.
Izquierdo et al., Madrid, Spain. In Plos One, 2010
Nucleostemin is expressed in Glioblastoma-cancer stem cells isolated from patient samples, and that its expression, conversely to what it has been described for ordinary stem cells, does not disappear when cells are differentiated.
Nucleostemin: a latecomer with new tricks.
Meng et al., Houston, United States. In Int J Biochem Cell Biol, 2009
Nucleostemin was first identified in neural stem cells and has become a focus of research in cell cycle control, tumorigenesis and cellular senescence.
Mesenchymal stem cells: molecular targets for tissue engineering.
Tripathi et al., Delhi, India. In Stem Cells Dev, 2007
However, MSC self-renewal has not received much attention, with Nucleostemin being the only recently identified proliferation molecule.
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