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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ectonucleoside triphosphate diphosphohydrolase 8

NTPDase8, E-NTPDase 8, Entpd8, nucleoside triphosphate diphosphohydrolase 8, liver ecto-ATP-diphosphohydrolase
Top mentioned proteins: CD39, ATPase, ACID, Apyrase, 5'-nucleotidase
Papers on NTPDase8
Mining the key regulatory genes of chicken inosine 5'-monophosphate metabolism based on time series microarray data.
Chen et al., Yangzhou, China. In J Anim Sci Biotechnol, 2014
In particular, Bmpr2, Pten and co-expression genes correlated with Entpd8 might play important roles in regulating IMP de novo synthesis, decomposition and salvage synthesis.
Ticlopidine in its prodrug form is a selective inhibitor of human NTPDase1.
Sévigny et al., Québec, Canada. In Mediators Inflamm, 2013
At 100 µM ticlopidine did not affect the activity of human NTPDase2, NTPDase3, and NTPDase8, nor of NPP1 and NPP3.
Nucleotides metabolizing ectoenzymes as possible markers of mesenchymal stem cell osteogenic differentiation.
Komoszyński et al., Toruń, Poland. In Biochem Cell Biol, 2013
Here, we report that although nucleoside triphosphate diphosphohydrolase (NTPDase)1 and NTPDase8 are engaged in the metabolism of ATP in MSC-derived osteoblasts, NTPDase3 is responsible for its metabolism in undifferentiated MSCs.
Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver.
Sévigny et al., Québec, Canada. In Am J Physiol Gastrointest Liver Physiol, 2012
Here we characterized the impact of the cellular distribution of hepatic ectonucleotidases, namely nucleoside triphosphate diphosphohydrolase (NTPDase)1/CD39, NTPDase2/CD39L1, NTPDase8, and ecto-5'-nucleotidase/CD73, and of their specific biochemical properties, on the levels of P1 and P2 receptor agonists, with an emphasis on adenosine-producing CD73.
Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception.
Molliver et al., Pittsburgh, United States. In Neuroscience, 2011
mRNA for NTPDase1-3, but not NTPDase8, was detected in lumbar DRG and spinal cord.
NTPDase family in zebrafish: Nucleotide hydrolysis, molecular identification and gene expression profiles in brain, liver and heart.
Bogo et al., Porto Alegre, Brazil. In Comp Biochem Physiol B Biochem Mol Biol, 2010
Homology-based searches identified the presence of NTPDase1-6 and NTPDase8 orthologs and the phylogeny also grouped three NTPDase2 and two NTPDase5 paralogs.
The stability of chicken nucleoside triphosphate diphosphohydrolase 8 requires both of its transmembrane domains.
Knowles et al., San Diego, United States. In Biochemistry, 2010
Chicken nucleoside triphosphate diphosphohydrolase 8 (NTPDase8) is a cell surface ectonucleotidase with a large extracellular domain (ECD) containing the active site and is anchored to the membrane by two transmembrane domains (TMDs) at the N- and C-termini.
Preservation of cochlear function in Cd39 deficient mice.
Robson et al., Auckland, New Zealand. In Hear Res, 2009
Gene expression analysis of other membrane-bound NTPDases with comparable hydrolytic activity demonstrated an up-regulation of Entpd2 and Entpd8 in the cochleae of Cd39 deficient mice.
Localization of plasma membrane bound NTPDases in the murine reproductive tract.
Sévigny et al., Québec, Canada. In Histochem Cell Biol, 2009
Activation of cellular nucleotide purinergic receptors is influenced by four plasma membrane-bound members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family, namely NTPDase1, NTPDase2, NTPDase3, and NTPDase8 that differ in their ecto-enzymatic properties.
Transmembrane domain interactions affect the stability of the extracellular domain of the human NTPDase 2.
Knowles et al., San Diego, United States. In Arch Biochem Biophys, 2008
Human NTPDase2 and chicken NTPDase8 are cell surface nucleotidases that contain two transmembrane domains (TMD) and five apyrase conserved regions (ACRs).
Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.
Sévigny et al., Québec, Canada. In Biochem Pharmacol, 2007
Except for MRS2179, all other antagonists significantly inhibited these ecto-ATPases; NTPDase3 being the most sensitive to inhibition and NTPDase8 the most resistant.
Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases.
Sévigny et al., Québec, Canada. In Br J Pharmacol, 2007
NTPDase2, NTPDase8, NPP3 and ecto-5'-nucleotidase activities were less affected.
Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8.
Sévigny et al., Québec, Canada. In Am J Physiol Gastrointest Liver Physiol, 2007
NTPDase8 is the canalicular ecto-ATPase/ATPDase and is responsible for the main hepatic NTPDase activity.
Molecular cloning and characterization of expressed human ecto-nucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) and its soluble extracellular domain.
Li et al., San Diego, United States. In Biochemistry, 2006
269, 2373-2382] and a mouse homologue that has been designated as E-NTPDase 8 [Bigonnesses et al. (2004) Biochemistry 43, 5511-5519].
Comparative genomic and expression analysis of the conserved NTPDase gene family in Xenopus.
Jones et al., Coventry, United Kingdom. In Genomics, 2006
During development, all NTPDase genes, except for NTPDase8, are expressed and display a distinct specific expression pattern, suggesting potentially different functions of these proteins during embryogenesis of X. laevis.
Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8.
Sévigny et al., Québec, Canada. In Biochemistry, 2004
Enzymatic properties of NTPDase8 (Entpd8) differ from those of other NTPDases and suggest an alternative way to modulate nucleotide levels and consequently P2Y and P2X receptor activation.
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