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NTH1 Nth1p

NTH1, neutral trehalase, NTHL1
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: OGG1, ACID, NEIL1, CAN, HAD
Papers on NTH1
3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair.
Schär et al., Bern, Switzerland. In Nucleic Acids Res, Feb 2016
The AP lyase activity of bifunctional DNA glycosylases (NTH1, NEIL1, FPG), however, was fully inhibited.
Inherited predisposition to colorectal cancer: towards a more complete picture.
Sampson et al., Cardiff, United Kingdom. In J Med Genet, Dec 2015
Recent findings, including mutations in POLE, POLD1 and NTHL1, will be highlighted, and we identify gaps in present knowledge and consider how these may be addressed through current and emerging genomic approaches.
DNA Base-Excision Repair Genes OGG1 and NTH1 in Brazilian Lung Cancer Patients.
De Marco et al., Belo Horizonte, Brazil. In Mol Diagn Ther, Dec 2015
The hOGG1 and NTH1 genes act in the DNA BER repair pathway and their involvement in lung cancer pathogenesis has been analyzed in several populations.
Homozygous deletion of ATC1 and NTC1 genes in Candida parapsilosis abolishes trehalase activity and affects cell growth, sugar metabolism, stress resistance, infectivity and biofilm formation.
Argüelles et al., Murcia, Spain. In Fungal Genet Biol, Dec 2015
A double homozygous atc1Δ/atc1Δ/ntc1Δ/ntc1Δ mutant (atc1Δ/ntc1Δ KO) was constructed in the pathogen opportunistic yeast Candida parapsilosis by disruption of the two chromosomal alleles coding for NTC1 gene (encoding a neutral trehalase) in a Cpatc1Δ/atc1Δ background (atc1Δ KO strain, deficient in acid trehalase).
Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors.
Foulkes et al., Montréal, Canada. In N Engl J Med, Dec 2015
A patient is described with multiple cancers and compound heterozygous mutations in NTHL1, a recently described polyposis gene.
The Mendelian colorectal cancer syndromes.
Tomlinson, Oxford, United Kingdom. In Ann Clin Biochem, Nov 2015
Most of the approximately 13 high-penetrance genes that predispose to CRC primarily predispose to colorectal polyps, and each gene is associated with a specific type of polyp, whether conventional adenomas (APC, MUTYH, POLE, POLD1, NTHL1), juvenile polyps (SMAD4, BMPR1A), Peutz-Jeghers hamartomas (LKB1/STK11) and mixed polyps of serrated and juvenile types (GREM1).
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Hazra et al., Berkeley, United States. In J Biol Chem, Nov 2015
As in mice deficient in each of the other four oxidized base-specific DGs (OGG1, NTH1, NEIL1, and NEIL3), Neil2-null mice show no overt phenotype.
Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways.
Saparbaev et al., Villejuif, France. In J Biol Chem, Jul 2015
Using a panel of eukaryotic and prokaryotic bifunctional DNA glycosylases/lyases (NEIL1, Nei, Fpg, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, and Nfo), the analysis of cleavage fragments by PAGE and MALDI-TOF/MS show that the G*[C8-N3]T* lesions in 17-mer duplexes are incised on either side of G*, that none of the recovered cleavage fragments contain G*, and that T* is converted to a normal T in the 3'-fragment cleavage products.
A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer.
Hoogerbrugge et al., Nijmegen, Netherlands. In Nat Genet, Jun 2015
In seven affected individuals from three unrelated families, we identified a homozygous germline nonsense mutation in the base-excision repair (BER) gene NTHL1.
Enhanced fermentative capacity of yeasts engineered in storage carbohydrate metabolism.
Matallana et al., Valencia, Spain. In Biotechnol Prog, 2015
Here we have engineered industrial strains in storage carbohydrate metabolism by overexpressing the GSY2 gene, that encodes the glycogen synthase enzyme, and deleting NTH1 gene, that encodes the neutral trehalase enzyme.
Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts.
Sugimura et al., Tokyo, Japan. In Free Radic Biol Med, 2014
To test this hypothesis, we examined the activities of the DNA glycosylase proteins OGG1, SMUG1, TDG, NEIL1, MUTYH, NTH1, MPG, and UNG2 against double-stranded oligonucleotides containing 1,N(6)-ethenoadenine (εA), 3,N(4)-ethenocytosine (εC), butanone-ethenocytosine (BεC), butanone-ethenoguanine (BεG), heptanone-ethenocytosine (HεC), or heptanone-ethenoguanine (HεG) using a DNA cleavage assay.
Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation.
Obsil et al., Praha, Czech Republic. In Physiol Res, 2013
In this minireview, we focus on mechanisms of the 14-3-3 protein-dependent regulation of three important 14-3-3 binding partners: yeast neutral trehalase Nth1, regulator of G-protein signaling 3 (RGS3), and phosducin.
Mechanism of high trehalose accumulation in a spore clone isolated from Shirakami kodama yeast.
Takahashi et al., Akita, Japan. In J Gen Appl Microbiol, 2013
Furthermore, the neutral trehalase activity of this spore clone is about 3-fold less than that of the laboratory strain although the gene for neutral trehalase, NTH1, functioned normally.
The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.
Stavnezer et al., Worcester, United States. In Plos One, 2011
deficiencies in Ogg1 and/or Nth1 do not lead to decreased DNA double strand breaks
The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.
Matallana et al., Valencia, Spain. In Microbiology, 2009
The behaviour of trehalase mutant strains demonstrates the participation of trehalases Nth1p, Nth2p and Ath1p in the mobilization of intracellular trehalose during growth recovery after saline stress.
Altered expression of the human base excision repair gene NTH1 in gastric cancer.
Sugimura et al., Hamamatsu, Japan. In Carcinogenesis, 2009
Downregulation of NTH1 is associated with gastric cancer.
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
Teebor et al., New York City, United States. In Dna Repair (amst), 2009
The high incidence of tumors in Nth1-/-Neil1-/- mice together with the activating mutation in the K-ras gene of their pulmonary tumors, reveal for the first time, the existence of mutagenic and carcinogenic oxidative damage to DNA which is not 8-OH-Gua.
[Construction and stress tolerance of trehalase mutant in Saccharomyces cerevisiae].
Guo et al., Tianjin, China. In Wei Sheng Wu Xue Bao, 2008
Gene disruption of NTH1 and ATH1 increased tolerance to freezing, heat, high-sugar and ethanol concentration.
Oxidative DNA damage repair in mammalian cells: a new perspective.
Roy et al., Galveston, United States. In Dna Repair (amst), 2007
Only two mammalian DNA glycosylases, OGG1 and NTH1 of E. coli Nth family, were previously characterized, which excise majority of the oxidatively damaged base lesions.
Molecular biology of trehalose and the trehalases in the yeast Saccharomyces cerevisiae.
Holzer et al., Freiburg, Germany. In Prog Nucleic Acid Res Mol Biol, 1997
Three trehalases have been described in S. cerevisiae: 1) the cytosolic neutral trehalase encoded by the NTH1 gene, and regulated by cAMP-dependent phosphorylation process, nutrients, and temperature; 2) the vacuolar acid trehalase encoded by the ATH1 gene, and regulated by nutrients; and 3) a putative trehalase Nth1p encoded by the NTH2 gene (homolog of the NTH1 gene) and regulated by nutrients and temperature.
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