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Protein tyrosine phosphatase, non-receptor type 11

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, SHP1, IgM, ACID
Papers using NS1 antibodies
Fractalkine in human inflammatory cardiomyopathy.
Gaetano Carlo, In PLoS ONE, 2010
... Transfection was performed with PVB19 nonstructural protein NS-1 plasmid (NS-1 pEGFP-C1) or control plasmid (pEGFP-C1) using 2 µg of each plasmid (Clontech, Mountain View, CA, USA), ...
Inducible rodent models of acquired podocyte diseases
Takano Tomoko et al., In Journal of Signal Transduction, 2008
... Antibodies were purchased from the following sources: PTP1B and SHP2 (BD Biosciences), PTP-PEST (Cell Signaling), ...
Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity.
Hooker Bill, In PLoS ONE, 2007
... Anti-PP2A (1504-1), anti-phospho-Shp-2 (2165-1) and anti-PAK (2247-1) antibodies were purchased from Epitomics (distributed by Euromedex, Mundolsheim, ...
Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin
Reichardt Louis F. et al., In The Journal of Cell Biology, 2006
... obtained from Sigma-Aldrich, anti–PSD-95 was obtained from Thermo Fisher Scientific, anti-PTP1B was obtained from EMD, anti–SHP-2 was obtained from Santa Cruz Biotechnology, Inc., and antiphosphotyrosine 4G10 ...
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
Birchmeier Walter et al., In The Journal of Cell Biology, 2002
... The N and C termini of NOMA-GAP and full-length human SHP2 were subcloned into the yeast expression vectors pGBT9, pGADT7 (CLONTECH Laboratories, Inc.), and pSrcBridge ...
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Papers on NS1
Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.
Legler et al., Kreuzlingen, Switzerland. In Immunity, Feb 2016
Finally, we identified CCL21-biased signaling that involved the phosphatase SHP2 to control efficient cell migration.
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
The signaling pathways known to mediate the actions of leptin include JAK-STAT signaling, PI3K-Akt-FoxO1 signaling, SHP2-ERK signaling, AMPK signaling, and mTOR-S6K signaling.
Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.
Van Etten et al., Toronto, Canada. In Blood, Feb 2016
Leukemogenesis was restored by expression of GAB2 but not by GAB2 mutants lacking binding sites for its effectors PI3K or SHP2.
A formulated double-stranded RNA diet for reducing Penaeus monodon densovirus infection in black tiger shrimp.
Attasart et al., Nakhon Pathom, Thailand. In J Invertebr Pathol, Feb 2016
Significant reductions in levels of PmDNV as assessed by PCR analysis of shrimp hepatopancreas were seen in both prophylactic and curative experiments after feeding shrimp with a formulated diet containing mixed inactivated bacteria harboring dsRNAs corresponding to the PmDNV ns1 and vp genes.
Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
Zhang et al., Dallas, United States. In Cell Cycle, Feb 2016
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatase non-receptor type 6 (PTPN6 or SHP-1), protein tyrosine phosphatase non-receptor type 11 (PTPN11 or SHP-2), or Src homology 2 domain-containing inositol phosphatase (SHIP), leading to negative regulation of immune cell activation.
A study on gender-related differences in laboratory characteristics of dengue fever.
Thakur et al., New Delhi, India. In Indian J Med Microbiol, Jan 2016
Studies have reported significant gender-related differences in serological tests for detection of NS1 antigen and IgM antibody used for diagnosing dengue fever.
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.
Guo et al., Shanghai, China. In Bioorg Med Chem Lett, Jan 2016
Their inhibitory effects on PTP1B and other PTPs (TCPTP, SHP1, SHP2 and LAR) were evaluated.
Development of a recombinant, chimeric tetravalent dengue vaccine candidate.
Stinchcomb et al., Deerfield, United States. In Vaccine, Jan 2016
In addition, TDV induced CD8(+) T cell responses to the non-structural NS1, NS3 and NS5 proteins of DENV.
Inhibitory leukocyte immunoglobulin-like receptors in cancer development.
Zhang et al., Shanghai, China. In Sci China Life Sci, Dec 2015
Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase (SHIP) to negatively regulate immune cell activation.
The genomic landscape of juvenile myelomonocytic leukemia.
Loh et al., San Francisco, United States. In Nat Genet, Nov 2015
Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies.
Non-coding recurrent mutations in chronic lymphocytic leukaemia.
Campo et al., Oviedo, Spain. In Nature, Nov 2015
We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11.
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
Bastian et al., San Francisco, United States. In Nat Genet, Oct 2015
Instead, other genetic alterations known to activate the MAPK and PI3K signaling cascades were identified in 73% of samples, affecting NF1, CBL, ERBB2, MAP2K1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA, some of which are candidates for targeted therapies.
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Xiao et al., Shanghai, China. In Nat Immunol, Jun 2015
Ablation of the gene encoding SHP-2 (Ptpn11; called 'Shp-2' here) in dendritic cells (DCs) and macrophages impaired Syk-mediated signaling and abrogated the expression of genes encoding pro-inflammatory molecules following fungal stimulation.
Guillain-Barre syndrome following dengue fever and literature review.
Jayalath et al., Kandy, Sri Lanka. In Bmc Res Notes, 2014
The diagnosis of dengue fever was confirmed as he had positive dengue NS1 antigen test on the third day of fever.
Shp-2 regulates the TrkB receptor activity in the retinal ganglion cells under glaucomatous stress.
Graham et al., Port Macquarie, Australia. In Biochim Biophys Acta, 2012
these findings implicate a molecular basis of Shp2 mediated TrkB deactivation leading to retinal ganglion cells (RGC) degeneration observed in glaucoma
Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome.
Tartaglia et al., Roma, Italy. In J Biol Chem, 2012
data demonstrate that the selection-by-function mechanism acting as driving force for PTPN11 mutations affecting codons 62 and 63 implies balancing of counteracting effects operating on the allosteric control of the function of SHP2
Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling.
Schaper et al., Magdeburg, Germany. In Mol Biosyst, 2012
The modeling results indicate that SHP2 does not act as a feedback inhibitor in an early phase of IL-6-induced Jak/STAT signaling. However, experimental data reveal that SHP2 exhibits a basal repressory function.
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.
Cantor et al., Boston, United States. In Genes Dev, 2012
These findings link SFK and Shp2 signaling pathways to the regulation of RUNX1 activity in hematopoiesis via control of RUNX1 multiprotein complex assembly.
PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?
Kontaridis et al., Boston, United States. In Trends Cardiovasc Med, 2011
Review: PTPN11 mutations cause LEOPARD syndrome (LS) and Noonan syndrome (NS), two disorders that are part of a newly classified family of autosomal dominant syndromes termed "RASopathies
More papers using NS1 antibodies
Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis
Neel Benjamin G. et al., In The Journal of Cell Biology, 2000
... Rabbit polyclonal anti-Akt1/2, Erk2, and Shp-2 rabbit antibodies were purchased from Santa Cruz Biotechnology, Inc ...
The EphA4 receptor regulates dendritic spine remodeling by affecting β1-integrin signaling pathways
Pasquale Elena B. et al., In The Journal of Cell Biology, 1999
... Antibodies to Fyn and SHP2 and a Cas polyclonal antibody were purchased from Santa Cruz Biotechnology, Inc ...
Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by β1 integrins
Languino Lucia R. et al., In The Journal of Cell Biology, 1997
... (Santa Cruz Biotechnology, Inc.); to Gab1 and to IRS-1 (Upstate Biotechnology); to hIGF-II (PeproTech); to Shp2 (Santa Cruz Biotechnology, Inc.); to phospho-Akt (Ser ...
Natural killer cell receptors
Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1996
... Anti–SHP-2 Ab, intact rabbit anti–mouse IgG, and F(ab′)2 rabbit anti–mouse IgG were purchased from Santa Cruz Biotechnology, Inc. ...
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