GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Integrin beta 3 binding protein
NRIF3, beta3-endonexin, CENP-R, TAP20, ITGB3BP
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] (from
NCBI)
Sponsored links
Top mentioned proteins:
ACID, annexin IV, CAN, CENP-C, MLF1IP
Papers on
NRIF3
Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.
New
Suita, Japan. In J Cell Biol, Jan 2016
Our data also suggest that CENP-O and CENP-R may regulate the size of the inner kinetochore without influencing the assembly of the outer kinetochore.
Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.
New
In J Clin Invest, Apr 2015
Eight were associated with metastasis-free survival in breast cancer patients, with integrin β3-binding protein (ITGB3BP), MAP3K8, NIMA-related kinase (NEK2), and SHC-transforming protein 1 (SHC1) being the most predictive.
The CENP-O complex requirement varies among different cell types.
Mishima, Japan. In Chromosome Res, 2014
CENP-U (CENP-50) is a component of the CENP-O complex, which includes CENP-O, CENP-P, CENP-Q, CENP-R, and CENP-U and is constitutively localized at kinetochores throughout the cell cycle in vertebrates.
Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain.
New York City, United States. In Bmc Cancer, 2013
BACKGROUND: Expression of NRIF3 (Nuclear Receptor Interacting Factor-3) rapidly and selectively leads to apoptosis of breast cancer cells.
P-glycoprotein (ABCB1) inhibited network of mitochondrion transport along microtubule and BMP signal-induced cell shape in chimpanzee left cerebrum by systems-theoretical analysis.
Beijing, China. In Cell Biochem Funct, 2012
Our result showed that ABCB1 transport and signal upstream network RAB2A inhibited ABCB1, and downstream ABCB1-inhibited SMAD1_2, NCK2, SLC25A46, GDF10, RASGRP1, EGFR, LRPPRC, RASSF2, RASA4, CA2, CBLB, UBR5, SLC25A16, ITGB3BP, DDIT4, PDPN, RAB2A in chimpanzee left cerebrum.
Genome-wide linkage and copy number variation analysis reveals 710 kb duplication on chromosome 1p31.3 responsible for autosomal dominant omphalocele.
Genève, Switzerland. In J Med Genet, 2012
The 710 kb duplication at 1p31.3 band contains seven known genes including FOXD3, ALG6, ITGB3BP, KIAA1799, DLEU2L, PGM1, and the proximal portion of ROR1.
The ABCs of CENPs.
Review
Mishima, Japan. In Chromosoma, 2011
Onto centromeric CENP-A chromatin is assembled the so-called constitutive centromere-associated network (CCAN) of 16 proteins distributed in several functional groups as follows: CENP-C, CENP-H/CENP-I/CENP-K/, CENP-L/CENP-M/CENP-N, CENP-O/CENP-P/CENP-Q/CENP-R/CENP-U(50), CENP-T/CENP-W, and CENP-S/CENP-X.
A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.
New York City, United States. In Mol Cell Biol, 2011
We previously reported that expression of NRIF3 (nuclear receptor interacting factor-3) rapidly and selectively leads to apoptosis of breast cancer cells.
Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins.
Mishima, Japan. In J Cell Biol, 2011
We found that the inner kinetochore region defined by CENP-A, CENP-C, CENP-R, and the C-terminal domain of CENP-T is deformed in the presence of tension, whereas the outer kinetochore region defined by Ndc80, Mis12, and CENP-E is not stretched even under tension.
Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells.
New York City, United States. In Cancer Res, 2009
Expression of the nuclear receptor interacting factor 3 (NRIF3) coregulator in a wide variety of breast cancer cells selectively leads to rapid caspase-2-dependent apoptotic cell death.
Impact of oxaliplatin and a novel DACH-platinum complex in the gene expression of HCT116 colon cancer cells.
Hong Kong, Hong Kong. In Oncol Rep, 2008
Antiapoptotic genes such as survivin, BRCA1 and ITGB3BP were up-regulated, and it is proposed that the inherent defense mechanism of the cell may have been triggered, creating potential resistance to apoptosis.
Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation.
GeneRIF
Houston, United States. In Oncogene, 2008
findings suggest that NRIF3-Ser28 is a physiologic target of Pak1 signaling and contributes to the enhanced NRIF3 co-activator activity, leading to coordinated potentiation of ERalpha transactivation
The human CENP-A centromeric nucleosome-associated complex.
Impact
San Diego, United States. In Nat Cell Biol, 2006
Seven new CENP-A-nucleosome distal (CAD) centromere components (CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) are identified as assembling on the CENP-A NAC.
Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.
GeneRIF
Houston, United States. In Mol Cell Biol, 2004
Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator
The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.
GeneRIF
New York City, United States. In Mol Cell Biol, 2004
Results suggest that breast cancer cells contain a novel "death switch" that can be specifically triggered by NRIF3 or death domain 1.
Reduced beta3-endonexin levels are associated with enhanced urokinase-type plasminogen activator receptor expression in ApoE-/- mice.
GeneRIF
München, Germany. In Thromb Res, 2003
in contrast to uPAR or NF-kappaB, the expression of beta(3)-endonexin was reduced in extracts of advanced atherosclerotic aortic tissue
Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.
GeneRIF
München, Germany. In J Cell Sci, 2002
This protein downregulates urokinase-type plasminogen activator receptor promoter activity.
Integrin cytoplasmic domain-binding proteins.
Review
Los Angeles, United States. In J Cell Sci, 2000
FAK, ILK and novel proteins such as TAP20) might also link integrins to signaling mechanisms and, in some cases (e.g.
Integrin cytoplasmic interactions and bidirectional transmembrane signalling.
Review
Toronto, Canada. In Curr Opin Cell Biol, 1996
The cytoplasmic domains of integrins are required for the transduction of this bidirectional information, and have recently been shown to participate in direct interactions with some novel cytoplasmic proteins, such as an ankyrin repeat containing serine/threonine protein kinase (integrin-linked kinase) and beta3 endonexin.
