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NFKB repressing factor

NRF, NF-kappaB repressing factor
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Nrf2, Nuclear Respiratory Factor 1, PGC, V1a, CAN
Papers using NRF antibodies
Evolution of mutation rates in bacteria.
Tyagi Anil Kumar, In PLoS ONE, 2005
... the Bejing isolates from South Africa (ZA) and the GC 1237 strain (DNA provided from NRF Centre of Excellence in Biomedical Tuberculosis Research/MRC Centre for ...
Papers on NRF
A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C.
Peng et al., Beijing, China. In Toxicol Sci, Feb 2016
Our in vitro study revealed a well-defined POD concentration of DOX below which adaptive induction of PGC-1α-mediated mitochondrial genes, including NRF-1, MnSOD, UCP2, and COX1, concurred with negligible changes in mitochondrial superoxide and cytotoxicity.
Chronic Arsenic Exposure-Induced Oxidative Stress is Mediated by Decreased Mitochondrial Biogenesis in Rat Liver.
Kumar et al., Rohtak, India. In Biol Trace Elem Res, Feb 2016
The entire phenomenon was associated with decrease in mitochondrial biogenesis as evident by decreased protein and mRNA expression of nuclear respiratory factor 1 (NRF-1), nuclear respiratory factor 2 (NRF-2), peroxisome proliferator activator receptor gamma-coactivator 1α (PGC-1α), and mitochondrial transcription factor A (Tfam) in arsenic-treated rat liver.
Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo.
Balog et al., Zagreb, Croatia. In Redox Biol, Feb 2016
In this study we address the question whether the E2-induced protective effect against hyperoxia is mediated by the Nrf-2/Keap-1 signaling pathway.
Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance.
Melzig et al., Taiwan. In Chem Biol Interact, Feb 2016
Nrf-2 activation might be involved in hyperoside induced up-regulation of phase II enzymes.
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.
Isik et al., Boston, United States. In Free Radic Biol Med, Nov 2015
The mammalian Nrf/CNC proteins (Nrf1, Nrf2, Nrf3, p45 NF-E2) perform a wide range of cellular protective and maintenance functions.
Current perspectives of molecular pathways involved in chronic Inflammation-mediated breast cancer.
Shukla et al., Lucknow, India. In Biochem Biophys Res Commun, Nov 2015
Immunomodulation mediated by cytokines, chemokines and several other growth factors present in the tumor microenvironment regulate chronic inflammatory response and alter crosstalk among various signaling pathways such as NF-κB, Nrf-2, JAK-STAT, Akt and MAPKs involved in the progression of breast cancer.
Nucleotides in neuroregeneration and neuroprotection.
Perez-Sen et al., Madrid, Spain. In Neuropharmacology, Oct 2015
Finally, general signaling pathways triggered by nucleotide receptors in neuronal populations converge on several intracellular kinases, such as PI3K/Akt, GSK3 and ERK1,2, as well as the Nrf-2/heme oxigenase-1 axis, which specifically link them to neuroprotection.
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.
Blackwell et al., Boston, United States. In Nature, Apr 2015
Here we show that rIIS can promote C. elegans longevity through a program that is genetically distinct from the dauer pathway, and requires the Nrf (NF-E2-related factor) orthologue SKN-1 acting in parallel to DAF-16.
EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway.
Hilliard et al., Brisbane, Australia. In Nature, Feb 2015
PSR-1 functions cell-autonomously in the regrowing neuron and, instead of acting in its canonical signalling pathway, acts in a parallel phagocytic pathway that includes the transthyretin protein TTR-52, as well as CED-7, NRF-5 and CED-6 (refs 9, 10, 11, 12).
A Metagenomics-Based Metabolic Model of Nitrate-Dependent Anaerobic Oxidation of Methane by Methanoperedens-Like Archaea.
Welte et al., Nijmegen, Netherlands. In Front Microbiol, 2014
A small part of the resulting nitrite is reduced to ammonium which may be catalyzed by a Nrf-type nitrite reductase.
[CNC proteins in physiology and pathology].
Skrzydlewska et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
CNC proteins consist of Bach1, Bach2 and 4 homologous transcription factors: Nrf1, Nrf2, Nrf3 and p45NF-E2.
Redox mechanisms of cardiomyocyte mitochondrial protection.
Piantadosi et al., Durham, United States. In Front Physiol, 2014
Simultaneously, a number of other DNA binding transcription factors are expressed and/or activated under redox control, such as Nuclear Respiratory Factor-1 (NRF-1), and lead to the induction of genes involved in both intracellular and mitochondria-specific repair mechanisms.
Mitochondrial SKN-1/Nrf mediates a conserved starvation response.
Curran et al., Los Angeles, United States. In Cell Metab, 2012
SKN-1/Nrf plays multiple essential roles in development and cellular homeostasis.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Blackwell et al., Boston, United States. In Cell Metab, 2012
Here we show that when TORC1 is inhibited genetically in C. elegans, SKN-1/Nrf, and DAF-16/FoxO activate protective genes, and increase stress resistance and longevity.
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.
Ristow et al., Jena, Germany. In Cell Metab, 2012
Induction of the ROS signal requires AAK-2 (AMPK), while PMK-1 (p38) and SKN-1 (NRF-2) are needed for the retrograde response.
JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5' and 3' untranslated regions.
Reboll et al., Hannover, Germany. In J Mol Biol, 2011
The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs.
Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor.
Kuo et al., Taipei, Taiwan. In J Immunol, 2009
Induction of NRF in human airway smooth muscle cells by neutrophil elastase mediates the suppression of interleukin (IL)-8/CXCL8 expression.
NF-kappaB activation by the viral oncoprotein StpC enhances IFN-gamma production in T cells.
Biesinger et al., Erlangen, Germany. In Immunol Cell Biol, 2008
saimiri transformation-associated protein of subgroup C induces NF-kappaB activation
NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.
Nourbakhsh et al., Hannover, Germany. In Rna, 2007
The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity.
Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.
Sizemore et al., Kent, United States. In Mol Carcinog, 2007
Induction of MMP-9 gene expression is regulated by oscillatory/cumulative activation of NFkappaB in a colon cancer cell line.
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