GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Ring finger protein 41
Nrdp1, RNF41, FLRF, neuregulin receptor degradation protein-1
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] (from
NCBI)
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Top mentioned proteins:
Ubiquitin, erbB-3, V1a, CAN, E3 ubiquitin ligase
Papers using
Nrdp1
antibodies
Transcriptomic analysis of mild hypothermia-dependent alterations during endothelial reperfusion injury.
Supplier
In PLoS ONE, 2009
... Nrdp1 (BETHYL Laboratories, Inc), anti-cleaved PARP, ...
Papers on
Nrdp1
K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.
New
Impact
Beijing, China. In Nat Immunol, Dec 2015
Here we found that Nrdp1, a ring finger-type E3 ligase, mediated Lys33 (K33)-linked polyubiquitination of the signaling kinase Zap70 and promoted the dephosphorylation of Zap70 by the acidic phosphatase-like proteins Sts1 and Sts2 and thereby terminated early TCR signaling in CD8(+) T cells.
The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1.
New
Seoul, South Korea. In Carcinogenesis, Dec 2015
The degradation of ErbB3 is a result of proteasomal degradation, possibly due to the ABPN-dependent upregulation of Nrdp1.
Nrdp1S, short variant of Nrdp1, inhibits human glioma progression by increasing Nrdp1-mediated ErbB3 ubiquitination and degradation.
New
Xuzhou, China. In J Cell Mol Med, Dec 2015
UNASSIGNED: The ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) is involved in the induction of apoptosis and suppression of tumour formation.
Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells.
New
Philadelphia, United States. In Diabetes, Oct 2015
High-throughput expression microarray and chromatin occupancy analyses reveal that Pdx1 regulates the expression of Clec16a, a type 1 diabetes gene and itself a key mediator of mitophagy through regulation of the E3 ubiquitin ligase Nrdp1.
Expression profiles and interaction suggest TBK1 can be regulated by Nrdp1 in response to immune stimulation in large yellow croaker Larimichthys crocea.
New
Xiamen, China. In Fish Shellfish Immunol, Oct 2015
In this study, the molecular characterization and immune response of TBK1 in Larimichthys crocea (named as LcTBK1) as well as its interaction with Nrdp1 were investigated.
MiR-497 promotes metastasis of colorectal cancer cells through Nrdp1 inhibition.
New
Jinan, China. In Tumour Biol, Sep 2015
We have recently shown that Nrdp1 inhibits phosphorylation of ErB3 in colorectal cancer (CRC) cells, to suppress epidermal growth factor receptor (EGFR) signaling-stimulated MMP7 activation for CRC metastasis.
Nrdp1-mediated ErbB3 degradation inhibits glioma cell migration and invasion by reducing cytoplasmic localization of p27(Kip1).
New
Xuzhou, China. In J Neurooncol, Sep 2015
We previously reported that loss of Nrdp1 contributes to human glioma progression by reducing apoptosis.
Decreased LRIG1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 upregulation and increased growth.
New
Nashville, United States. In Oncogene, Aug 2015
We found that ErbB3 protein levels and cell surface presentation were increased following fulvestrant treatment, focusing our attention on proteins that regulate ErbB3 at the cell surface, including Nrdp1, NEDD4 and LRIG1.
Regulation of ERBB3/HER3 signaling in cancer.
Review
Houston, United States. In Oncotarget, 2014
These proteins include PI3K, Shc, and E3 ubiquitin ligases NEDD4 and Nrdp1.
The diabetes susceptibility gene Clec16a regulates mitophagy.
Impact
Philadelphia, United States. In Cell, 2014
Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1.
Could FaRP-Like Peptides Participate in Regulation of Hyperosmotic Stress Responses in Plants?
Review
Paris, France. In Front Endocrinol (lausanne), 2013
First, we demonstrated the response of Arabidopsis thaliana cultured cells to a metazoan FLP (FLRF).
The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein β (C/EBPβ).
GeneRIF
Hangzhou, China. In J Biol Chem, 2012
demonstrate that Nrdp1-mediated ubiquitination and activation of C/EBPbeta contributes to a ubiquitin-dependent nonproteolytic pathway that up-regulates Arg1 expression and promotes M2 macrophage polarization
Overexpression of Nrdp1/FLRF sensitizes cells to oxidative stress.
GeneRIF
Nantong, China. In Biochem Biophys Res Commun, 2011
these data provide insights into understanding the potential role of Nrdp1 in cell growth, apoptosis and oxidative stress, and in the pathogenesis of Parkinson's disease.
Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum.
GeneRIF
Sacramento, United States. In Mol Cell Biol, 2011
Data demonstrate that Nrdp1 preferentially associates with the nascent form of ErbB3 to accelerate its degradation, and that the two proteins colocalize at the endoplasmic reticulum.
RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding.
GeneRIF
Gent, Belgium. In J Cell Sci, 2011
RNF41 interacts with JAK2-associated cytokine receptor complexes and modulates their cell surface exposure and signalling.
Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice.
GeneRIF
Beijing, China. In Plos One, 2010
Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt, ERK1/2 and STAT3.
E3 ubiquitin ligases in ErbB receptor quantity control.
Review
Sacramento, United States. In Semin Cell Dev Biol, 2010
Here the involvement of ErbB-directed E3 ubiquitin ligases is discussed, including Nrdp1-mediated ErbB3 degradation, ErbB4 degradation mediated by Nedd4 family E3 ligases, and CHIP-mediated ErbB2 degradation.
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.
Impact
GeneRIF
Shanghai, China. In Nat Immunol, 2009
Data suggest that Nrdp1 functions as both an adaptor protein and an E3 unbiquitin ligase to regulate TLR responses in different ways.
The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies.
Review
Baltimore, United States. In J Mammary Gland Biol Neoplasia, 2008
These proteins include the intracellular RING finger E3 ubiquitin ligase Nrdp1 and the leucine-rich protein LRIG-1 that mediate receptor degradation.
Negative regulation of ErbB family receptor tyrosine kinases.
Review
Sacramento, United States. In Br J Cancer, 2004
These include intracellular RING finger E3 ubiquitin ligases such as cbl and Nrdp1 that mediate ErbB receptor degradation, and may include a wide variety of secreted and transmembrane proteins that suppress receptor activation by growth factor ligands.
