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Glutamate receptor, ionotropic, N-methyl D-aspartate 2D

N-methyl-D-aspartate receptor subunit; expressed in mid-brain structures with peak expression at day P7 [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NMDA receptor, NR2B, NR2A, ACID, HAD
Papers on NR2D
Hunger States Control the Directions of Synaptic Plasticity via Switching Cell Type-Specific Subunits of NMDA Receptors.
Yang et al., Zhengzhou, China. In J Neurosci, Oct 2015
Mechanistically, we also find that food deprivation increases the expressions of NR2C/NR2D/NR3-containing NMDA receptors (NMDARs) at AgRP neurons that contribute to the inductions of LTD, whereas it decreases their expressions at POMC neurons.
Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells.
Parada et al., Ribeirão Preto, Brazil. In Proc Natl Acad Sci U S A, 2015
In following experiments we observed attenuation of PGE2-induced hyperalgesia in the paw by the knockdown of NMDAR subunits NR1, NR2B, NR2D, and NR3A with antisense-oligodeoxynucleotide treatment in the DRG.
Physical activity correlates with glutamate receptor gene expression in spinally-projecting RVLM neurons: a laser capture microdissection study.
Mueller et al., Detroit, United States. In Brain Res, 2014
There were no significant difference in the gene expression of NMDA (NR1, NR2A, NR2B, NR2C and NR2D), AMPA (GLUR1, GLUR2 and GLUR3) and GABAA (GABAA1 and GABAA2) receptor subunits.
Opposing role of NMDA receptor GluN2B and GluN2D in somatosensory development and maturation.
Watanabe et al., Sapporo, Japan. In J Neurosci, 2014
Here we compared functional roles of GluN2B (GluRε2 or NR2B) and GluN2D (GluRε4 or NR2D), two major regulatory subunits of neonatal NMDA receptors, in development of whisker-related patterning at trigeminal relay stations.
From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes.
Olivera et al., Salt Lake City, United States. In Toxicon, 2014
Channel currents measured in Xenopus oocytes demonstrate conantokins conBk-A, conBk-B, and conBk-C have highest potencies for NR2D containing receptors, in contrast to previously characterized conantokins that preferentially block NR2B containing NMDA receptors.
D-aspartate affects NMDA receptor-extracellular signal-regulated kinase pathway and upregulates androgen receptor expression in the rat testis.
Di Fiore et al., Caserta, Italy. In Theriogenology, 2014
We found expression of N-Methyl-D-Aspartic Acid (NMDA) receptor messenger RNAs for NR1, NR2A, and NR2D receptor subunits.
Yokukansan, a traditional Japanese medicine, adjusts glutamate signaling in cultured keratinocytes.
Ikeda et al., Tokyo, Japan. In Biomed Res Int, 2013
The mRNA expression levels of NMDA receptor 2D (NMDAR2D) and glutamate aspartate transporter (GLAST) were also determined in YKS-stimulated cultured keratinocytes.
N-[2-(N-(2-mercaptoethyl)) amino ethyl]-N-(2-mercaptoethyl)-3,5-dimethylacetamide amantadine-technetium
Shan, Bethesda, United States. In Unknown Journal, 2012
NR1 has eight subtypes and encodes the ion channel, while NR2 has four subtypes (NR2A, NR2B, NR2C and NR2D) and mediates the fast excitatory neurotransmission in combination with NR1 (2).
Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.
Hamre et al., Memphis, United States. In Neurotoxicol Teratol, 2012
No differences in expression of NR2A, NR2C or NR2D are found in any brain region examined during ethanol consumption and acute ethanol withdrawal.
[Chromosomal instability, microsatellite instability and CpG island methylator phenotype: roles in small intestinal carcinogenesis].
Schirmacher et al., Heidelberg, Germany. In Pathologe, 2011
In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis.
NMDA receptor subunit expression in the supraoptic nucleus of adult rats: dominance of NR2B and NR2D.
Sladek et al., Aurora, United States. In Brain Res, 2011
NR1, NR2B, and NR2D were robustly expressed in the supraoptic nucleus of adult rats.
The role of N-methyl-D-aspartate receptor subunits in the rat thalamic mediodorsal nucleus during central sensitization.
Suda et al., Tokyo, Japan. In Brain Res, 2011
Expression of NR2D mRNAs in the thalamus was increased by mustard oil application to molar tooth pulp. This was prevented by lidocaine & reversed by MK-801. Naloxone antagonized this reversal.
Chopra, Bethesda, United States. In Unknown Journal, 2011
The NR1 subunit of the NMDAR is known to be distributed in all parts of the brain; of the different NR2 subtypes, NR2A is found throughout the brain, whereas NR2B, NR2C, and NR2D are present mainly in the forebrain (including the cerebral cortex, hippocampus, and the olfactory lobes), cerebellum, and the lower brain stem, respectively.
Chopra, Bethesda, United States. In Unknown Journal, 2011
The NR1 subunit of the NMDAR is known to be distributed in all parts of the brain; of the different NR2 subtypes, NR2A is found throughout the brain, whereas NR2B, NR2C, and NR2D are present mainly in the forebrain (including the cerebral cortex, hippocampus, and the olfactory lobes), cerebellum, and the lower brain stem, respectively.
Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Furukawa et al., Atlanta, United States. In Nat Commun, 2010
The deactivation time of GluN1/GluN2D receptors is influenced by the conformational variability of the ligand-binding domain and the structure of the ligand.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Paoletti et al., Paris, France. In Nature, 2009
NMDARs exist as multiple subtypes with distinct pharmacological and biophysical properties that are largely determined by the type of NR2 subunit (NR2A to NR2D) incorporated in the heteromeric NR1/NR2 complex.
Cellular prion protein null mice display normal AMPA receptor mediated long term depression.
Zamponi et al., Calgary, Canada. In Prion, 2008
We have recently shown a novel modulation of NMDA receptors by PrP(C) that results in neuroprotection via silencing of NMDA receptors containing NR2D subunits, whereas no effects on AMPA receptor function could be observed (Khosravani, et al.
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.
Fern et al., Leicester, United Kingdom. In Nature, 2006
NR1, NR2A, NR2B, NR2C, NR2D and NR3A subunits showed clustered expression in cell processes, but NR3B was absent.
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.
Jan et al., San Francisco, United States. In Nature, 1994
Based on heterologous co-expression studies, it is inferred that NR1 encodes an essential subunit of NMDA receptors and that functional diversity of NMDA receptors in vivo is effected by differential incorporation of subunits NR2A-NR2D.
Trafficking and Targeting of NMDA Receptors
Wenthold et al., Boca Raton, United States. In Unknown Journal, 0001
Furthermore, evidence indicates the incorporation of more than one type of NR2 subunit in each complex (tri-heteromeric NR1/NR2X/NR2Y) such as NR1/NR2A/NR2B receptors in hippocampal neuron synapses, NR1/NR2A/NR2C in cerebellar granule cell synapses, and NR1/NR2B/NR2D in substantia nigra dopaminergic neurons [8].
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