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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A

may play a role in synaptic transmission, learning and memory [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NR2B, NMDA receptor, ACID, CAN, V1a
Papers on NR2A
Impaired hippocampal synaptic plasticity and NR2A/2B expression ratio in remifentanil withdrawal rats.
Zhang et al., Tianjin, China. In Neurotoxicology, Feb 2016
Immunohistochemistry results demonstrated increased NR2A/NR2B ratio that should be included depression of LTP.
Functional topography of cardiovascular regulation along the rostrocaudal axis of the rat posterior insular cortex.
Fontes et al., Belo Horizonte, Brazil. In Clin Exp Pharmacol Physiol, Feb 2016
Gene expression of NMDA receptor subunits NR2A and NR2B in the IC was confirmed by RT-PCR.
Functional Regulation of PI3K-Associated Signaling in the Accumbens by Binge Alcohol Drinking in Male but not Female Mice.
Finn et al., Portland, United States. In Neuropharmacology, Feb 2016
Expression of genes encoding mGlu1, mGlu5, the NR2A subunit of the NMDA receptor, and Homer2 were all decreased by binge alcohol consumption in males, while females were relatively resistant (only phosphoinositide-dependent protein kinase 1 was decreased).
Sex-dependent and independent effects of long-term voluntary wheel running on bdnf mRNA and protein expression.
Roth et al., College Park, United States. In Physiol Behav, Feb 2016
Total RNA was isolated from the hippocampus and expression of total Bdnf, Bdnf transcript IV, tPA, Pgc-1a, GluR1, NR2A, and NR2B were assessed with quantitative RT-PCR and total and mature Bdnf protein were assessed with ELISA.
Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway.
Yuan et al., Shanghai, China. In Neurobiol Learn Mem, Jan 2016
In addition, molecular and cellular studies revealed several alterations including: (1) the enhanced ratio of excitatory to inhibitory synapses; (2) increased expression of NMDA receptors NR2A; (3) enhanced activation of ERK signaling; (4) lowered number of the mushroom- and bifurcate-shaped dendritic spines in NP65 KO mice.
[The developmental switch of visual cortex NMDA receptor NR2 subunits and its implications for visual plasticity].
Zhao et al., Tianjin, China. In Zhonghua Yan Ke Za Zhi, Jun 2015
These tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits, usually a combination of NR2A and NR2B.
Anti-NR2A/B Antibodies and Other Major Molecular Mechanisms in the Pathogenesis of Cognitive Dysfunction in Systemic Lupus Erythematosus.
Mak et al., Singapore, Singapore. In Int J Mol Sci, 2014
This review will focus on the potential pathogenic factors involved in NPSLE, including anti-N-methyl-d-aspartate receptor subunit NR2A/B (anti-NR2A/B) antibodies, matrix metalloproteinase-9, neutrophil extracellular traps and pro-inflammatory mediators.
Meta-analysis of the association between N-methyl-d-aspartate receptor antibodies and schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder.
Najjar et al., New York City, United States. In Schizophr Res, 2014
Seropositive participants in psychiatric groups had various combinations of IgG, IgM, and IgA class antibodies against NR1, NR1/NR2B, and NR2A/NR2B subunits.
Involvement of NR1, NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring.
Zhu et al., Xi'an, China. In Behav Brain Res, 2013
Additionally, expression of NR1 and NR2A subunit of N-methyl-D-aspartate receptor (NMDAR) in the hippocampus (HIP), prefrontal cortex (PFC) and striatum (STR) was studied.
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.
von Spiczak et al., Bern, Switzerland. In Nat Genet, 2013
We detected new heterozygous mutations in GRIN2A in 27 of 359 affected individuals from 2 independent cohorts with IFE (7.5%; P = 4.83 × 10(-18), Fisher's exact test).
N-methyl-D-aspartate (NMDA) receptor composition modulates dendritic spine morphology in striatal medium spiny neurons.
Di Luca et al., Milano, Italy. In J Biol Chem, 2012
treatment with D1 receptor agonist leads to a significant decrease of NR2A-containing NMDA receptors and to a concomitant increase of spine head width
Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension.
Pan et al., Houston, United States. In J Biol Chem, 2012
CK2-mediated GluN2B phosphorylation contributes to increased synaptic GluN2A, which potentiates pre- and postsynaptic NMDAR activity and the excitability of PVN presympathetic neurons in hypertension.
Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95.
Stephenson et al., London, United Kingdom. In J Biol Chem, 2012
We show that NR2A subunits interact directly with PSD-95 via the C-terminal ESDV motif and additionally via an Src homology 3 domain-binding motif that associates with the Src homology 3 domain of PSD-95.
NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult.
Meaney et al., Philadelphia, United States. In Neurochem Int, 2012
balance between concurrent activation of NR2B-containing and NR2A-containing NMDARs dictates neuronal fate following excitotoxicity
Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors.
Dityatev et al., Hamburg, Germany. In J Neurosci, 2012
Inhibition of the GluN2A subtype reduces long term potentiation to the same level in NCAM-deficient and wild-type (NCAM-positive) littermate mice and abolishes the rescue by d-cycloserine in NCAM-deficient mice.
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
Kutsche et al., Erlangen, Germany. In Nat Genet, 2010
Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Paoletti et al., Paris, France. In Nature, 2009
NMDARs exist as multiple subtypes with distinct pharmacological and biophysical properties that are largely determined by the type of NR2 subunit (NR2A to NR2D) incorporated in the heteromeric NR1/NR2 complex.
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Stys et al., Ottawa, Canada. In Nature, 2006
In contrast, the Ca2+ increase in myelin was abolished by broad-spectrum NMDA receptor antagonists (MK-801, 7-chlorokynurenic acid, d-AP5), but not by more selective blockers of NR2A and NR2B subunit-containing receptors (NVP-AAM077 and ifenprodil).
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.
Fern et al., Leicester, United Kingdom. In Nature, 2006
NR1, NR2A, NR2B, NR2C, NR2D and NR3A subunits showed clustered expression in cell processes, but NR3B was absent.
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