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Neuropeptide Y receptor Y1

NPY-IR, neuropeptide Y receptor, NPY1R, NPY1
G protein-coupled receptor for neuropeptide Y and peptide YY [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Neuropeptide, neuropeptide Y, HAD, ACID, CAN
Papers on NPY-IR
Locus coeruleus response to single-prolonged stress and early intervention with intranasal neuropeptide Y.
Serova et al., Valhalla, United States. In J Neurochem, Dec 2015
Single-prolonged stress (SPS)-triggered long-term changes in the locus coeruleus/norepinephrine (LC/NE) system with increased tyrosine hydroxylase (TH) protein and CRH receptor 1(CRHR1) mRNA and lower neuropeptide Y receptor 2 (Y2R) mRNA levels as well as elevated corticotropin-releasing hormone (CRH) in the central nucleus of amygdala (CeA) that were prevented by early intervention with intranasal neuropeptide Y (NPY).
Chronic administration of methamphetamine promotes atherosclerosis formation in ApoE-/- knockout mice fed normal diet.
Gu et al., Wuhan, China. In Atherosclerosis, Nov 2015
Moreover, mRNA expressions of NPY1R, NPY2R and NPY5R in aortic and myocardial tissue were also significantly upregulated in M4 and M8 groups.
NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4.
Jackson et al., Pittsburgh, United States. In Am J Physiol Heart Circ Physiol, Nov 2015
We examined the effects of NPY1-36 and PYY1-36 on the proliferation of and collagen production ([(3)H]proline incorporation) by CFs isolated from Wistar-Kyoto (WKY) normotensive rats and spontaneously hypertensive rats (SHRs).
Dual effects of human adipose tissue-derived mesenchymal stem cells in human lung adenocarcinoma A549 xenografts and colorectal adenocarcinoma HT-29 xenografts in mice.
Kang et al., Seoul, South Korea. In Oncol Rep, Oct 2015
Notably, histone cluster 1, H2aj and neuropeptide Y receptor Y4 were found to be expressed in direct or inverse proportion to tumor size in both xenograft models.
Penultimate proline in neuropeptides.
Clemmer et al., Bloomington, United States. In Anal Chem, Sep 2015
In order to probe the effect of penultimate proline on neuropeptide conformations, IMS-MS experiments were performed on two model peptides in which penultimate proline residues were known to be important for biological activity: the N-terminal region of human neuropeptide Y (NPY1-9, Tyr(1)-Pro(2)-Ser(3)-Lys(4)-Pro(5)-Asp(6)-Asn(7)-Pro(8)-Gly(9)-NH2) and a tachykinin-related peptide (CabTRP Ia, Ala(1)-Pro(2)-Ser(3)-Gly(4)-Phe(5)-Leu(6)-Gly(7)-Met(8)-Arg(9)-NH2).
miR-29a Participated in Nacre Formation and Immune Response by Targeting Y2R in Pinctada martensii.
Du et al., Zhanjiang, China. In Int J Mol Sci, 2014
Results of the target analysis indicated that neuropeptide Y receptor type 2 (Y2R) was the potential target of Pm-miR-29a.
Neuropeptides as therapeutic targets to combat stress-associated behavioral and neuroendocrinological effects.
Jaggi et al., Patiāla, India. In Cns Neurol Disord Drug Targets, 2014
For example, NPY may exhibit anxiolytic effects by activating NPY1 and Y5 receptors, while pro-depressive effects are produced through NPY2 and Y4 receptors.
Automated solid-phase peptide synthesis to obtain therapeutic peptides.
Beck-Sickinger et al., Leipzig, Germany. In Beilstein J Org Chem, 2013
The synthesis and application of SPPS is described for neuropeptide Y receptor analogs as an example for bioactive hormones.
Galanin receptor/neuropeptide y receptor interactions in the central nervous system.
Narváez et al., Málaga, Spain. In Curr Protein Pept Sci, 2013
There is evidence for the existence of interactions between Galanin Receptor and Neuropeptide Y Receptor in the nucleus of the solitarii tract (NTS), hypothalamus and dorsal raphe nucleus probably taking place with the formation of heteromers between Galanin Receptor and Neuropeptide Y Y1 Receptor.
Leung, Bethesda, United States. In Unknown Journal, 2012
NPY receptors, such as NPY1R, have been identified in a variety of tissues, including the brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle (4).
NPY controls fear conditioning and fear extinction by combined action on Y₁ and Y₂ receptors.
Sperk et al., Innsbruck, Austria. In Br J Pharmacol, 2012
Data from knockout (KO) mice suggest roles for neuropeptide Y (Npy) and Npy1 receptors in extinction of conditioned fear. Npy1r/Npy2r double KO mice display excessive recall of conditioned fear/impaired fear extinction.
Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors.
Holliday et al., Nottingham, United Kingdom. In Biochim Biophys Acta, 2012
The influence of beta-arrestin adaptors and endocytosis mechanisms on plasma membrane diffusion and particle brightness of GFP-tagged neuropeptide Y (NPY) receptors, was investigated.
Association study of 45 candidate genes in nicotine dependence in Han Chinese.
Ma et al., Chengdu, China. In Addict Behav, 2012
For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism.
Ghrelin interacts with neuropeptide Y Y1 and opioid receptors to increase food reward.
Dickson et al., Göteborg, Sweden. In Endocrinology, 2012
Ghrelin interacts with neuropeptide Y Y1 and opioid receptors to increase food reward
Neuropeptide Y Y1 receptor hippocampal overexpression via viral vectors is associated with modest anxiolytic-like and proconvulsant effects in mice.
Woldbye et al., Copenhagen, Denmark. In J Neurosci Res, 2012
Npy1 receptor transgene overexpression is associated with modest anxiolytic-like effect on mice in the open field and elevated plus maze tests.
Leung, Bethesda, United States. In Unknown Journal, 2011
PKR1 shares 33% identity with human neuropeptide Y receptor-2, and PKR1 is expressed in the brain, spleen, prostate, testis, leukocytes, pancreas, adrenal gland, thyroid, salivary gland, pituitary, stomach, small intestine, colon, and rectum.
A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans.
Kim et al., Cambridge, United States. In Science, 2009
With the use of quantitative genetic analysis, we determined that the pathogen susceptibility difference between the laboratory wild-type strain N2 and the wild isolate CB4856 is caused by a polymorphism in the npr-1 gene, which encodes a homolog of the mammalian neuropeptide Y receptor.
Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor.
Ernfors et al., Stockholm, Sweden. In Nature, 2001
Neuropeptide Y (NPY) is believed to exert antinociceptive actions by inhibiting the release of substance P and other 'pain neurotransmitters' in the spinal cord dorsal horn.
Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans.
Bargmann et al., San Francisco, United States. In Cell, 1998
Natural isolates of C. elegans exhibit either solitary or social feeding behavior.
Role of the Y5 neuropeptide Y receptor in feeding and obesity.
Palmiter et al., Seattle, United States. In Nat Med, 1998
Neuropeptide Y (NPY), a 36-amino-acid neuromodulator abundantly expressed in the brain, has been implicated in the regulation of food intake and body weight.
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