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Neuronal PAS domain protein 2

NPAS2, neuronal PAS domain protein 2, MOP4
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CLOCK, Tic, period 2, CRY1, period 3
Papers on NPAS2
Diurnal neurobiological alterations after exposure to clozapine in first-episode schizophrenia patients.
Lu et al., Beijing, China. In Psychoneuroendocrinology, Feb 2016
RESULTS: Compared with healthy controls, schizophrenia patients presented disruptions in diurnal rhythms of the expression of PER1, PER3, and NPAS2 and the release of orexin, accompanied by a delayed phase in the expression of PER2, decreases in PER3 and NPAS2 expression, and an increase in cortisol levels at baseline.
Genetic Correlates of Individual Differences in Sleep Behavior of Free-Living Great Tits (Parus major).
Mueller et al., München, Germany. In G3 (bethesda), Feb 2016
Microsatellites in the CLOCK and NPAS2 clock genes exhibited an association with sleep duration relative to night length, and morning latency to exit the nest box, respectively.
[Circadian markers and genes in bipolar disorder].
Belliviera et al., Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
A PER3 polymorphism is associated with better overall survival in diffuse large B-cell lymphoma in Mexican population.
Scott et al., Monterrey, Mexico. In Cancer Biomark, 2014
METHODS: Sixteen high-risk non-synonymous polymorphisms in circadian genes (CLOCK, CRY2, CSNK1E, CSNK2A1, NPAS2, PER1, PER2, PER3, PPP2CA, and TIM) were genotyped by screening PCR.
Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis.
Mandelin et al., Helsinki, Finland. In Plos One, 2014
OBJECTIVE: Patients with rheumatoid arthritis (RA) have altered circadian rhythm of circulating serum cortisol, melatonin and IL-6, as well as disturbance in the expression of clock genes ARNTL2 and NPAS2.
Photoperiodic Modulation of Circadian Clock and Reproductive Axis Gene Expression in the Pre-Pubertal European Sea Bass Brain.
Canário et al., Faro, Portugal. In Plos One, 2014
We found that the clock genes clock, npas2, bmal1 and the BPG genes gnrh, kiss and kissr share conserved transcription factor frameworks in their promoters, suggesting co-regulation.
Circadian abnormalities as markers of susceptibility in bipolar disorders.
Etain et al., Créteil, France. In Front Biosci (schol Ed), 2013
Several circadian genes have been found to be associated with bipolar disorders: at least three studies have reported positive associations for each of CLOCK, NPAS2, ARNTL1, NR1D1, PER3, RORB and CSNK1epsilon.
Mechanisms of rapid antidepressant effects of sleep deprivation therapy: clock genes and circadian rhythms.
Bunney et al., Irvine, United States. In Biol Psychiatry, 2013
The central circadian clock genes, BMAL1/CLOCK (NPAS2), bind to Enhancer Boxes to initiate the transcription of circadian genes, including the period genes (per1, per2, per3).
Genetics of prion diseases.
Collinge et al., London, United Kingdom. In Curr Opin Genet Dev, 2013
Two recent genome wide association studies in human have identified four new loci of interest: ZBTB38-RASA2 in UK CJD cases and MTMR7 and NPAS2 in variant CJD.
Clock gene variants in mood and anxiety disorders.
Partonen, Helsinki, Finland. In J Neural Transm, 2012
The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression.
A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk.
Shen et al., Nanjing, China. In Breast Cancer Res Treat, 2011
found a novel functional SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-) 17-5p and miR-519e to the 3'UTR of NPAS2
Crosstalk between components of circadian and metabolic cycles in mammals.
Schibler et al., Genève, Switzerland. In Cell Metab, 2011
NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK, NPAS2, and HSF1), nutrient-sensing transcriptional regulatory proteins (e.g., CREB-CBP-CRCT2, FOXO-p300, nuclear receptors, PGC-1, and SP1 family members) and protein kinases (e.g., AMPK), are plausible candidates for conveying a cell's metabolic state to the core clock circuitry.
Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.
Rajeevan et al., Atlanta, United States. In Neuropsychobiology, 2010
Convergent functional genomics allowed the identification of novel candidate genes, GRIK2 and NPAS2, involved in glutamatergic neurotransmission and the circadian rhythm, respectively, that are potentially associated with CFS.
Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.
Franken et al., Lausanne, Switzerland. In Plos One, 2010
DNA-binding of NPAS2 and BMAL1 to Per2 was also decreased by SD, although SD is known to increase Per2 expression in the cortex. DNA-binding to Per1 and Cry1 was not affected by SD
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene.
Burris et al., Jupiter, United States. In J Biol Chem, 2010
Data demonstrate that NPAS2 is also a RORalpha and REV-ERBalpha target gene.
ARNTL (BMAL1) and NPAS2 gene variants contribute to fertility and seasonality.
Partonen et al., Helsinki, Finland. In Plos One, 2009
ARNTL and NPAS2 SNPs were associated with reproduction and with seasonal variation.
Reciprocal regulation of haem biosynthesis and the circadian clock in mammals.
Lee et al., Houston, United States. In Nature, 2004
Several members of the core clock mechanism are PAS domain proteins, one of which, neuronal PAS 2 (NPAS2), has a haem-binding motif.
Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.
McKnight et al., Dallas, United States. In Science, 2003
results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal light:dark cycle and feeding conditions and that NPAS2 is critical for adaptability to food restriction
NPAS2: a gas-responsive transcription factor.
McKnight et al., Columbus, United States. In Science, 2003
Neuronal PAS domain protein 2 (NPAS2) is a mammalian transcription factor that binds DNA as an obligate dimeric partner of BMAL1 and is implicated in the regulation of circadian rhythm.
NPAS2: an analog of clock operative in the mammalian forebrain.
McKnight et al., Dallas, United States. In Science, 2001
Neuronal PAS domain protein 2 (NPAS2) is a transcription factor expressed primarily in the mammalian forebrain.
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