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Neuronal PAS domain protein 1

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HIF-1alpha, CAN, NPAS3, OUT, Lhx6
Papers on NPAS1
NPAS1 represses the generation of specific subtypes of cortical interneurons.
Rubenstein et al., San Francisco, United States. In Neuron, 2015
We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE).
19q13.32 microdeletion syndrome: three new cases.
Graham et al., Los Angeles, United States. In Eur J Med Genet, 2014
These findings are probably related to a deletion of some combination of the 20-23 genes in common between these two patients, especially NPAS1, NAPA, ARHGAP35, SLC8A2, DHX34, MEIS3, and ZNF541.
DNase hypersensitive sites and association with multiple sclerosis.
Ramagopalan et al., Oxford, United Kingdom. In Hum Mol Genet, 2014
Several new candidate MS-associated genes located within regions of suggestive association were identified by GRAIL (CARD11, FCRL2, CHST12, SYK, TCF7, SOCS1, NFKBIZ and NPAS1).
Daily rhythmicity of clock gene transcripts in atlantic cod fast skeletal muscle.
Fernandes et al., Bodø, Norway. In Plos One, 2013
In particular, they were all detected in fast skeletal muscle, with the exception of neuronal PAS (Per-Arnt-Single-minded) domain-containing protein (npas1) and rora.
Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation.
Whitelaw et al., Adelaide, Australia. In Nucleic Acids Res, 2013
Active bHLH/PAS heterodimers consist of a ubiquitous signal-regulated subunit (e.g., hypoxia-inducible factors, HIF-1α/2α/3α; the aryl hydrocarbon receptor, AhR) or tissue-restricted subunit (e.g., NPAS1/3/4, Single Minded 1/2), paired with a general partner protein, aryl hydrocarbon receptor nuclear translocator (Arnt or Arnt2).
Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct signaling pathways and epigenetic control.
Elhadidy et al., Al Manşūrah, Egypt. In Plos One, 2011
Transcripts of genes involved in neural tube development and patterning (ALDH1A2, FOXA2), progenitor marker genes (LMX1a, ALDH1A1, SOX10), proliferation of neural progenitors (WNT1 and WNT3a), neuroplastin (NPTN), POU3F1 (OCT6), neuroligin (NLGN4X), MEIS2, and NPAS1 were up-regulated in both cell populations.
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.
Rubenstein et al., Bethesda, United States. In J Comp Neurol, 2008
We provide evidence that Lhx6 mediates these effects through promoting expression of receptors that regulate interneuron migration (ErbB4, CXCR4, and CXCR7), and through promoting the expression of transcription factors either known (Arx) or implicated (bMaf, Cux2, and NPAS1) in controlling interneuron development.
Identification of novel deletion polymorphisms in breast cancer.
Miki et al., Tokyo, Japan. In Int J Oncol, 2008
The results were confirmed by quantitative PCR (Q-PCR) and 4 genes, the REV1L, ZNF14, NPAS1 and APOBEC3B genes, were selected.
Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons.
Lim et al., Singapore, Singapore. In J Neurosci Res, 2007
These results suggest that NPAS1 plays a novel and important role in regulating TH level of dopaminergic neurons in the ventral midbrain during development.
NPAS1 regulates branching morphogenesis in embryonic lung.
Sunday et al., Durham, United States. In Am J Respir Cell Mol Biol, 2007
Npas1 can regulate myofibroblast distribution, branching morphogenesis, and neuroendocrine cell differentiation in murine embryonic lung.
Neuronal PAS domain protein 1 is a transcriptional repressor and requires arylhydrocarbon nuclear translocator for its nuclear localization.
Lim et al., Singapore, Singapore. In J Biol Chem, 2006
Neuronal PAS domain protein 1 (NPAS1), a basic helix-loop-helix-PAS transcription factor expressed in the central nervous system, has been suggested to be involved in neuronal differentiation.
Cellular patterns of transcription factor expression in developing cortical interneurons.
Rubenstein et al., San Francisco, United States. In Cereb Cortex, 2006
Toward elucidating the mechanisms underlying the generation of interneuron diversity, we have studied in mice the expression patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB).
The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.
McKnight et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2005
The neuronal PAS domain protein 3 (NPAS3) gene encoding a brain-enriched transcription factor was recently found to be disrupted in a family suffering from schizophrenia.
Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells.
Miura et al., Tokyo, Japan. In J Neurosci Res, 2005
One bHLH-PAS protein, neuronal PAS domain protein 1 (NPAS1), is reported to be expressed only in the central nervous system beginning at the late embryonic stage, but its function is unknown.
Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.
McKnight et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2004
a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis
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