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proteins. Page last changed on 19 Dec 2016.
Rho GTPase activating protein 33
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010] (from
Rosário et al., Berlin, Germany. In Mol Psychiatry, Sep 2015
Here we show, using genetically engineered mice, that the Cdc42 GTPase-activating multiadaptor protein, NOMA-GAP, regulates autism-like social behavior in the mouse, as well as dendritic spine and synapse development.
Birchmeier et al., Berlin, Germany. In J Cell Biol, 2007
Results show that neurite outgrowth multiadaptor RhoGAPprotein, NOMA-GAP, plays an essential role downstream of NGF in promoting neurite outgrowth and extension by recruiting SHP2 and activating Cdc42.