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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Serine/threonine/tyrosine kinase 1

Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Fas Ligand, PrP, CAN, V1a, caspase-8
Papers on NOK
Cost-effectiveness of once daily GLP-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in Norway.
McLeod et al., Stockholm, Sweden. In J Med Econ, Jul 2015
Simulated healthcare costs, taken from the public payer perspective, were derived from microcosting and diagnosis related groups, discounted at 4% per annum and reported in Norwegian krone (NOK).
Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters.
Mertz et al., Madison, United States. In J Virol, Feb 2015
Here, we examined BLIMP1's role in inducing EBV lytic gene expression in numerous EBV(+) epithelial and B-cell lines and activating transcription from Rp. BLIMP1 addition was sufficient to induce reactivation in latently infected epithelial cells derived from gastric cancers, nasopharyngeal carcinomas, and normal oral keratinocytes (NOK) as well as some, but not all B-cell lines.
Expression of MICA in oral squamous carcinoma cells and its effect on NK cells.
Liu et al., Fuzhou, China. In Int J Clin Exp Med, 2014
METHODS: Normal oral mucosa epithelial cell line NOK and oral squamous carcinoma cell lines OEC-M1, SAS and SCC-25 were used in this study.
Quantitative study of epigenetic signature in head and neck squamous cell carcinoma.
Shreen et al., In Turk J Med Sci, 2014
MATERIALS AND METHODS: A genome-wide promoter methylation microarray was used to compare HNSCC cell line (n = 8), primary human oral keratinocytes (NOK; n = 8) transduced with FOXM1 and EGFP, and HNSCC tissue biopsies (n = 3).
NOK mediated mitogenic signaling is altered by P203L and V395I mutations.
Liu et al., Beijing, China. In Front Biosci, 2014
NOK(P203L) is identical to serine/threonine/tyrosine kinase 1 (STYK1), the aliases of NOK, while the V395I mutation was recovered from human glioblastoma.
Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia.
Watanabe et al., Sapporo, Japan. In Int J Oncol, 2014
In this study, we examined whether the widely expressed serine threonine tyrosine kinase 1 (STYK1)/novel oncogene with kinase domain (NOK) acts as a drug resistance factor in acute leukemia.
Combining linkage and association mapping identifies RECEPTOR-LIKE PROTEIN KINASE1 as an essential Arabidopsis shoot regeneration gene.
Vereecke et al., Gent, Belgium. In Proc Natl Acad Sci U S A, 2014
We show that the variation in regeneration capacity between the Arabidopsis accessions Nok-3 and Ga-0 is determined by five quantitative trait loci (QTL): REG-1 to REG-5.
Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin via enhancing apoptosis pathways in vitro and in vivo.
Chen et al., T'ai-chung-shih, Taiwan. In Toxicol Sci, 2014
Pretreatment of Nok-1 monoclonal antibody, a Fas signaling inhibitor, or Bax inhibitor peptide V5 repressed the Andro-induced cleavage of procaspase and the sensitization to CDDP-induced apoptosis.
Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of rapamycin signaling pathway.
Castilho et al., Rio Grande, Brazil. In J Biomed Opt, 2014
Oral keratinocytes (NOK-SI) maintained under nutritional-deficit culture medium (2% fetal bovine serum) were irradiated with InGaAlP laser (660 nm; 40 mW; 0.04  cm2 spot size) in punctual and contact modes.
Diagnostic relevance of overexpressed serine threonine tyrosine kinase/novel oncogene with kinase domain (STYK1/ NOK) mRNA in colorectal cancer.
Somi et al., Tabrīz, Iran. In Asian Pac J Cancer Prev, 2013
In this study, we examined whether serine threonine tyrosine kinase 1 (STYK1)/novel oncogene with kinase domain (NOK) is overexpressed in patients with colorectal cancer.
Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development.
Wei et al., Pittsburgh, United States. In Int J Dev Neurosci, 2013
We show that: 1, the optic vesicle and undifferentiated retinal neuroepithelium only express Crb2a; 2, Crb1 and Crb2a expressions overlap extensively in the undifferentiated neural tube epithelium; 3, Crb2b expression is the weakest of the three and is restricted to the ventral-most regions of the anterior CNS; and 4, Nok and Crb proteins require each other for their apical localization in neuroepithelium.
Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer.
Li et al., Xi'an, China. In Bmc Cancer, 2013
BACKGROUND: The expression of novel oncogenic kinase (NOK), a member of the protein tyrosine kinase (PTK) family, has been observed in several human malignancies including non-small cell lung cancer (NSCLC).
Arabidopsis GLASSY HAIR genes promote trichome papillae development.
Kirik et al., Normal, United States. In J Exp Bot, 2013
Two--TRICHOME BIREFRINGENCE (TBR) and NOK (Noeck)--have been reported previously to have the glassy trichome mutant phenotype.
Keratinocytes and head and neck squamous cell carcinoma cells regulate urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in fibroblasts.
Nowinski et al., Uppsala, Sweden. In Anticancer Res, 2013
BACKGROUND: To investigate possible differences in the effects of soluble factors from oral squamous cell carcinoma (SCC) cells (UT-SCC-87) and normal oral keratinocytes (NOK) on fibroblast expression of genes involved in tumor stroma turnover.
NOK/STYK1 has a strong tendency towards forming aggregates and colocalises with epidermal growth factor receptor in endosomes.
Zhang et al., Beijing, China. In Biochem Biophys Res Commun, 2012
Taken together, NOK has a strong tendency towards forming aggregates, which may have physiological implications and provide the first evidence that this novel receptor kinase is colocalised with EGFR in endosomes to participate in a post-internalisation step of EGFR.
Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina.
Masai et al., Okinawa, Japan. In Mech Dev, 2010
the ratio of the number of cells undergoing neurogenic cell division to the total number of cells undergoing mitosis was decreased in retinas of nagie oko knockout zebrafish.
Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.
Nakagawa et al., Tokyo, Japan. In Cancer Sci, 2009
Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.
Overexpression of serine threonine tyrosine kinase 1/novel oncogene with kinase domain mRNA in patients with acute leukemia.
Watanabe et al., Sapporo, Japan. In Exp Hematol, 2009
results indicate that STYK1/NOK mRNA is widely expressed in the patients with acute leukemia and suggest that inhibition of this molecule could potentially serve as a novel therapeutic target
Intact retinal pigment epithelium maintained by Nok is essential for retinal epithelial polarity and cellular patterning in zebrafish.
Wei et al., Pittsburgh, United States. In J Neurosci, 2009
that Nok is required for retinal pigment epithelium integrity in a tissue-autonomous manner
nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina.
Malicki et al., Boston, United States. In Nat Genet, 2002
Mutations of the zebrafish gene nagie oko (nok) produce a severe disruption of retinal architecture, indicating a key role for this locus in neuronal patterning.
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