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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

N-myristoyltransferase 2

NMT2, N-myristoyltransferase 2, thi2
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, caspase-3, PrP, HAD
Papers using NMT2 antibodies
Stimulation of glycogen phosphorylase kinase from rabbit skeletal muscle by organic solvents
Sharma Rajendra K. et al., In Journal of Biomedicine and Biotechnology, 1978
... Anti-NMT2 was obtained from BD biosciences, Canada ...
Papers on NMT2
Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
Kuypers et al., Oakland, United States. In J Lipid Res, Dec 2015
We determined that the acyl-CoA binding protein ACBD6 stimulated the N-myristoyltransferase reaction of NMT2.
Transcriptomic analysis of Camellia ptilophylla and identification of genes associated with flavonoid and caffeine biosynthesis.
Hang et al., Nanjing, China. In Genet Mol Res, 2014
Transcriptomic sequencing captured two N-methyl nucleosidase genes named NMT1 and NMT2.
Regulation of N-myristoyltransferase by the calpain and caspase systems.
Dimmock et al., In Indian J Biochem Biophys, 2014
In higher eukaryotes, two isoforms of NMT have been identified (NMT1 and NMT2) which share about 76% amino acid sequence identity in humans.
An improved method and cost effective strategy for soluble expression and purification of human N-myristoyltransferase 1 in E. coli.
Sharma et al., Saskatoon, Canada. In Mol Cell Biochem, 2014
N-myristoyltransferase (NMT) is an indispensible enzyme, which exists as two isoforms (NMT1 and NMT2) in humans and has proven roles in development of cancerous states.
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
Tate et al., London, United Kingdom. In Nat Commun, 2013
Small-molecule inhibition through a conserved substrate-binding pocket is also demonstrated by solving the crystal structures of inhibitor-bound NMT1 and NMT2.
Golgi traffic and integrity depend on N-myristoyl transferase-1 in Arabidopsis.
Brandizzi et al., East Lansing, United States. In Plant Cell, 2013
Eukaryotes have conserved N-myristoylation enzymes, involving one or two N-myristoyltransferases (NMT1 and NMT2), among which NMT1 is the major enzyme.
Regulation of co- and post-translational myristoylation of proteins during apoptosis: interplay of N-myristoyltransferases and caspases.
Berthiaume et al., Edmonton, Canada. In Faseb J, 2013
We show for the first time that both N-myristoyltransferases (NMTs) 1 and 2 are cleaved during apoptosis and that the caspase-3- or -8-mediated cleavage of NMT1 at Asp-72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp-25.
Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia.
Knuutila et al., Helsinki, Finland. In Mol Cytogenet, 2012
Some miR-181c target genes such as PBX3, HSP90B1, NMT2 and RAD21 have been associated with drug response.
A new, robust, and nonradioactive approach for exploring N-myristoylation.
Porubsky et al., Heidelberg, Germany. In J Lipid Res, 2012
Recombinant murine NMT1 and NMT2 were characterized using this new method.
A fluorescence-based assay for N-myristoyltransferase activity.
Leatherbarrow et al., London, United Kingdom. In Anal Biochem, 2012
Here we report a sensitive fluorescence-based assay to study the enzymatic activity of human NMT1 and NMT2 based on detection of CoA by 7-diethylamino-3-(4-maleimido-phenyl)-4-methylcoumarin.
N-myristoyltransferase in the leukocytic development processes.
Sharma et al., Saskatoon, Canada. In Cell Tissue Res, 2011
The protein myristoylation process is catalyzed by the enzyme N-myristoyltransferase (NMT), which exists as two isoforms: NMT1 and NMT2.
Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer.
Rosenberg et al., Boston, United States. In Breast Cancer Res, 2010
Knockdown of the putative oncogenic miRNA miR-182 and miR-183, both highly overexpressed in DCIS, increased the expression of chromobox homolog 7 (CBX7) (which regulates E-cadherin expression), DOK4, NMT2 and EGR1.
A maize thiamine auxotroph is defective in shoot meristem maintenance.
Scanlon et al., Ithaca, United States. In Plant Cell, 2010
Positional cloning of blk1-R identified a predicted missense mutation in a highly conserved amino acid encoded by thiamine biosynthesis2 (thi2).
Suppression of human immunodeficiency virus type-1 production by coexpression of catalytic-region-deleted N-myristoyltransferase mutants.
Misumi et al., Kumamoto, Japan. In Biol Pharm Bull, 2009
N-Myristoyltransferase (NMT) isozymes, i.e., NMT1 and NMT2, are essential host factors for the AIDS-causing human immunodeficiency virus type-1 (HIV-1), by which the viral proteins Pr55(gag) and Nef are N-myristoylated.
N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef.
Smith et al., State College, United States. In J Gen Virol, 2008
Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence.
N-myristoylation regulates the SnRK1 pathway in Arabidopsis.
Meinnel et al., Gif-sur-Yvette, France. In Plant Cell, 2007
Protein N-myristoylation is systematically associated with shoot meristem development and that SnRK1 (for SNF1-related kinase) is one of its essential primary targets. [NMT2]
Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes?
Harris et al., Boston, United States. In Am J Med Genet A, 2007
Disruption of the gene for NMT2 by a t(8;10) translocation in a male with hypogonadism.
Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review).
Sharma et al., Canada. In Int J Mol Med, 2007
A number of viral and eukaryotic proteins which undergo a lipophilic modification by the enzyme N-myristoyltransferase (NMT: NMT1 and NMT2) are required for signal transduction and regulatory functions.
Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases.
Legrand et al., Rennes, France. In Mol Cell Biochem, 2006
NMT2 protein exhibited functional myristoyltransferase activity, but appeared to be 4-time less active than NMT1.
N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.
Sharma et al., Saskatoon, Canada. In Febs Lett, 2006
Protein-protein interaction of NMTs revealed that m-calpain interacts with NMT1 while caspase-3 interacts with NMT2.
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