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Non-metastatic cells 6, protein expressed in

NM23-H6, Nme6, IPIA-Alpha
Nucleoside diphosphate (NDP) kinases (EC, such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: nm23, Nucleoside-Diphosphate Kinase, CAN, P18, p53
Papers on NM23-H6
Purine metabolism gene deregulation in Parkinson's disease.
Ferrer et al., Barcelona, Spain. In Neuropathol Appl Neurobiol, Dec 2015
METHODS: Analysis of mRNA using real-time quantitative PCR of 22 genes involved in purine metabolism in the substantia nigra, putamen and cerebral cortex area 8 in PD at different stages of disease progression, and localization of selected purine metabolism-related enzymes with immunohistochemistry. RESULTS: Reduced expression of adenylate kinase 2 (AKA2), AK3, AK4, adenine phosphoribosyltransferase, ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), ENTPD3, nonmetastatic cells 3, nucleoside-diphosphatese kinase 3 (NME1), NME7 and purine nucleoside phosphorylase 1 (PNP1) mRNA in the substantia nigra at stages 3-6; up-regulation of ADA mRNA in the frontal cortex area 8 at stages 3-4 and of AK1, AK5, NME4, NME5, NME6, 5'-nucleotidase (NT5E), PNP1 and prune homolog Drosophila at stages 5-6.
Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression.
Filipp et al., Merced, United States. In Mol Cancer Res, Dec 2015
In addition, dihydropyrimidine dehydrogenase (DPYD) and other important pyrimidine-related genes: DPYS, AK9, CAD, CANT1, ENTPD1, NME6, NT5C1A, POLE, POLQ, POLR3B, PRIM2, REV3L, and UPP2 are significantly enriched in somatic mutations relative to the background mutation rate.
Acute L-glutamine deprivation affects the expression of TP53-related protein genes in U87 glioma cells.
Minchenko et al., In Fiziol Zh, 2013
We have studied the effect of acute L-glutamine deprivation on the expression oftumor protein 53 (TP53)-related genes such as TOPORS (topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase), TP53BPI (TP53 bindingprotein 1), TP53TG1 (TP53 inducible gene 1), SESN1 (p53 regulatedPA26 nuclear protein), NME6 (NME/NM23 nucleoside diphosphate kinase 6), and ZMAT3 (zinc finger Matrin-type 3) in glioma cells with ERN1 knockdown.
Gene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms?
Söderman et al., Jönköping, Sweden. In Plos One, 2012
The expression levels of four genes identified by microarray screening (PLCB2, HVCN1, CTSS, and DEF8) and one purine/thiopurine related gene (NME6) correlated significantly with the clinical activity of Crohn's disease.
A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal.
Lu et al., Taipei, Taiwan. In Stem Cells, 2012
Among the 27 genes, we chose nonmetastatic cell 6 (Nme6, also named as Nm23-H6) and nonmetastatic cell 7 (Nme7, also designated as Nm23-H7) to study first.
Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula.
Cetković et al., Zagreb, Croatia. In Naunyn Schmiedebergs Arch Pharmacol, 2011
The purpose of this study was to address structural and functional properties of group II Nme6 gene/protein ortholog from the marine sponge Suberites domuncula, Nme6, in order to elucidate its evolutionary history.
Nme protein family evolutionary history, a vertebrate perspective.
Bobe et al., Rennes, France. In Bmc Evol Biol, 2008
Nme1, Nme2, Nme3, and Nme4 belong to Group I while vertebrate Nme5, Nme6, Nme7, Nme8, and Nme9 belong to Group II.
In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling.
Hofmann et al., Frankfurt am Main, Germany. In Pharmacol Res, 2006
Among these 30 genes we found a high proportion of genes associated with apoptotic cell death, cell proliferation and cell cycle signalling including complement lysis inhibitor (clusterin/CLU), beta-catenin interacting protein (ICAT), peroxisome proliferator activated receptor alpha (PPARalpha), TNF alpha converting enzyme (ADAM17/TACE), homeo box A3 (HOX1), inositol polyphosphatase 5-phosphatase type IV (PPI5PIV) and inhibitor of p53 induced apoptosis alpha (IPIA-Alpha/NM23-H6).
Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer.
Seitz et al., Homburg, Germany. In J Pathol, 2005
These findings indicate that nm23-H6, and particularly nm23-H4 and -H7, may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.
A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis.
Nakamura et al., Kumamoto, Japan. In J Cell Biochem, 1999
We present the molecular cloning of a novel human NDP kinase gene, termed Nm23-H6.
NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3.
Lambeth et al., Grand Forks, United States. In Hum Genet, 1999
Here we report the cDNA sequence for a sixth member of this family, NME6.
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