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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nemo-like kinase

NLK, Nemo-like kinase
Top mentioned proteins: Incontinentia Pigmenti, TCF, CAN, V1a, TAK1
Papers on NLK
Microfluidics‑based optimization of neuroleukin‑mediated regulation of articular chondrocyte proliferation.
Liu et al., Dalian, China. In Mol Med Report, Jan 2016
Neuroleukin (NLK) is a multifunctional protein that possesses growth factor functions, and its expression has been associated with cartilage development and bone regeneration, however its direct role in chondrocyte proliferation remains to be fully elucidated.
miR-362-3p targets nemo-like kinase and functions as a tumor suppressor in renal cancer cells.
Tang et al., Shenzhen, China. In Mol Med Report, Jan 2016
Further experiments demonstrated that the overexpression of miR‑362‑3p resulted in decrease expression levels of nemo-like kinase.
The emerging role of Nemo-like kinase (NLK) in the regulation of cancers.
Li et al., Hefei, China. In Tumour Biol, Dec 2015
Nemo-like kinase (NLK) is an evolutionarily conserved mitogen-activated protein (MAP) kinase-related kinase that is highly expressed in neural tissues and minimally detected in others.
NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.
Guan et al., Shanghai, China. In Genes Dev, Dec 2015
In this study, we identified the Nemo-like kinase (NLK) as an mTORC1 regulator in mediating the osmotic and oxidative stress signals.
MicroRNA-92b promotes tumor growth and activation of NF-κB signaling via regulation of NLK in oral squamous cell carcinoma.
Peng et al., Wuhan, China. In Oncol Rep, Nov 2015
In western blotting and luciferase assay, NLK was identified as a direct and functional target of miR-92b.
Genome-wide association study of growth traits in the Jinghai Yellow chicken.
Wang et al., Yangzhou, China. In Genet Mol Res, 2014
Three proximal genes (BTRC, NLK, and NF1) were found to participate in the Wnt-signaling pathway and mitogen-activated protein kinase signaling pathway.
Nemo-like kinase, a multifaceted cell signaling regulator.
Ishitani et al., Fukuoka, Japan. In Cell Signal, 2013
Nemo-like kinase (NLK) is an evolutionarily conserved MAP kinase-related kinase.
Common variation in Nemo-like kinase is associated with risk of ovarian cancer.
Couch et al., Rochester, United States. In Cancer Epidemiol Biomarkers Prev, 2012
Single nucleotide polymorphisms in NLK is associated with ovarian cancer.
Nemo-like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling.
Canalis et al., Hartford, United States. In J Cell Biochem, 2012
Nlk suppresses osteoblastogenesis by opposing BMP/Smad and WNT canonical signaling
Expression of NLK and its potential effect in ovarian cancer chemotherapy.
Cheng et al., Nantong, China. In Int J Gynecol Cancer, 2011
expression suppressed in the development of ovarian cancer
Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology.
Clemens et al., Pittsburgh, United States. In Neurobiol Dis, 2011
NEMO binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.
Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).
Matsuda et al., Sapporo, Japan. In J Biol Chem, 2011
ZIPK may serve as a transcriptional regulator of canonical Wnt/beta-catenin signaling through interaction with NLK/TCF4.
NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed.
Edery et al., United States. In Cell, 2011
Phosphorylation by the NEMO/NLK kinase at the "per-short" domain on PER stimulates phosphorylation by DOUBLETIME (DBT/CK1δ/ɛ) at several nearby sites.
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.
Roux et al., Montréal, Canada. In Microbiol Mol Biol Rev, 2011
There are additional, atypical MAPK enzymes, including ERK3/4, ERK7/8, and Nemo-like kinase (NLK), which have distinct regulation and functions.
Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells.
Katoh, Tokyo, Japan. In Curr Pharm Biotechnol, 2011
Non-canonical WNT signals inhibit canonical WNT signaling by using MAP3K7-NLK signaling cascade.
Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases.
Li et al., Kansas City, United States. In Birth Defects Res C Embryo Today, 2010
In addition, β-catenin:T-cell factor/lymphoid enhancer factor-mediated gene expression is downregulated by CaMKII-TAK1-NLK.
Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.
Itoh et al., Nagoya, Japan. In Nat Cell Biol, 2010
NLK negatively regulates Notch-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.
Kato et al., Tokyo, Japan. In Nat Cell Biol, 2007
Wnt-5a activates NLK (Nemo-like kinase), which in turn phosphorylates a histone methyltransferase, SETDB1 (SET domain bifurcated 1), leading to the formation of a co-repressor complex that inactivates PPAR-gamma function through histone H3-K9 methylation.
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans.
Bowerman et al., Eugene, United States. In Nature, 1999
Consistent with action in a common pathway, mom-4 and lit-1 exhibit similar mutant phenotypes and encode components of the mitogen-activated protein kinase (MAPK) pathway that are homologous to vertebrate transforming-growth-factor-beta-activated kinase (TAK1) and NEMO-like kinase (NLK), respectively.
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.
Matsumoto et al., Nagoya, Japan. In Nature, 1999
MOM-4 and LIT-1 are homologous to TAK1 (a kinase activated by transforming growth factor-beta) mitogen-activated protein-kinase-kinase kinase (MAP3K) and MAP kinase (MAPK)-related NEMO-like kinase (NLK), respectively, in mammalian cells.
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