Developmental expression of the neuroligins and neurexins in fragile X mice.
Hamilton, Canada. In J Comp Neurol, Apr 2016
Sex differences in hippocampal expression of NLGN2, NRXN1, NRXN2, and NRXN3 mRNAs and in S1 cortex expression of NRXN3 mRNAs were observed WT mice, whereas sex differences in NLGN3, NRXN1, NRXN2, and NRXN3 mRNA expression in the hippocampus and in NLGN1, NRXN2 and NRXN3 mRNA expression in S1 cortex were detected in FMR1-KO mice.
Shedding light on glioma growth.
Boston, United States. In Cell, Jun 2015
In this issue of Cell, Venkatesh et al. demonstrate that this also occurs in the brain, identifying neuronal activity-induced secretion of neuroligin-3 as a novel mechanism promoting glioma proliferation.
How far can mice carry autism research?
Cambridge, United States. In Cell, 2014
In the face of growing controversy about the utility of genetic mouse models of human disease, Rothwell et al. report on a shared mechanism by which two different neuroligin-3 mutations, associated with autism spectrum disorders in humans, produce an enhancement in motor learning.
A review on the current neuroligin mouse models.
Hangzhou, China. In Sheng Li Xue Bao, 2012
In most of the models, including the human autism-linked NL3 and NL4 mutation mice, there are social interaction defects, memory impairment and repetitive behaviors.
A synaptic trek to autism.
Paris, France. In Curr Opin Neurobiol, 2009
Mutations in NLGN3/4, SHANK3, or NRXN1 alter synaptic function and lead to mental retardation, typical autism, or Asperger syndrome.