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NK2 homeobox 8

NKX2-8, nkx-2.8
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Top mentioned proteins: PAX9, CAN, SET, POLYMERASE, AFP
Papers on NKX2-8
Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage.
Kim et al., Taejŏn, South Korea. In Hum Mol Genet, 2014
The mesoderm development-related genes NKX2-8, TNFSF11 and NFATC1 acquired promoter methylation during neural differentiation even though they were already silenced in hES cells.
Decreased expression of the Nkx2.8 gene correlates with tumor progression and a poor prognosis in HCC cancer.
Cao et al., Shanghai, China. In Cancer Cell Int, 2013
BACKGROUND: Nkx2.8 (Nk2 homeobox 8) is a novel NK-2 gene family member that has been implicated in the progression of human cancer.
Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis.
Van Criekinge et al., Amsterdam, Netherlands. In J Pathol, 2013
For 12 genes (CLIC3, CREB3L1, FAM19A4, LFNG, LHX1, MRC2, NKX2-8, NPTX-1, PHACTR3, PRDM14, SOST and TNFSF13) specific methylation in HPV-containing cell lines was confirmed by semi-quantitative methylation-specific PCR.
Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.
Bannasch et al., Davis, United States. In Plos Genet, 2012
The associated region on canine chromosome 8 (pgenome  =3.0 × 10(-5)), after 100,000 permutations, encodes 18 genes, including NKX2-8, a homeobox gene which is expressed in the developing neural tube.
The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway.
Song et al., Guangzhou, China. In Carcinogenesis, 2012
overexpression of Nkx2.8 resulted in downregulation of p-FOXO3a and inhibition of MEK/ERK pathway activity. silencing Nkx2.8 led to upregulation of p-FOXO3a and increase of MEK/ERK pathway activity.
One allele's loss is another's gain: alterations of NKX2-8 in non-small cell lung cancer.
Shaw et al., Stanford, United States. In Clin Cancer Res, 2011
Large-scale genetic changes such as loss or gain of chromosomes are important drivers of solid tumor carcinogenesis.
Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.
Locker et al., New York City, United States. In Clin Cancer Res, 2011
Most tumors have low expression of Nkx2-8, and its expression can inhibit growth of some lung cancer cells.
Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.
Potti et al., Durham, United States. In Proc Natl Acad Sci U S A, 2009
Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of lung cancer patients with poor survival and were shown to exhibit resistance to cisplatin
Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer.
Mu et al., United States. In Proc Natl Acad Sci U S A, 2007
Mapping of the commonly amplified region revealed there are three genes in the core region, all of which encode transcription factors with either established lung developmental function (TTF1/NKX2-1, NKX2-8) or potential lung developmental function (PAX9).
Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia.
Locker et al., New York City, United States. In Cancer Res, 2006
Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system.
Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers.
Ushijima et al., Tokyo, Japan. In Oncogene, 2004
Treatment of a cancer cell line with a demethylating agent, 5-aza-2'-deoxycytidine, restored the expression of 13 genes, RASGRF2, ADAM23, NEF3, NKX2-8, HAND1, EGR4, PRG2, FBN2, CDH2, TLL1, NPTX1, NTSR1 and THBD, showing their silencing by methylation of their 5' CGIs.
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
Nakamura et al., Tokyo, Japan. In Nat Cell Biol, 2004
SMYD3 bound to a motif, 5'-CCCTCC-3', present in the promoter region of downstream genes such as Nkx2.8.
Regulation of alpha-fetoprotein expression by Nkx2.8.
Locker et al., New York City, United States. In Mol Cell Biol, 2002
A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor.
A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma.
Locker et al., Pittsburgh, United States. In J Biol Chem, 1998
The new factor is the eighth vertebrate factor related to nk-2, hence nkx-2.8.
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