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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cyclin-dependent kinase-like 3

NKIAMRE, cdkl3, cyclin-dependent kinase like 3
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, HAD, CDC2, Cho, Lyn
Papers on NKIAMRE
Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
Li et al., Vienna, Austria. In Behav Brain Res, Jan 2016
In addition, our analysis showed protein kinases WNK1, LYN, VRK1, ABL1, CDK4, CDKL3, SgK223 and ADCK1, and protein phosphatases PTPRF, ACP1, DNAJC6, SSH2 and UBASH3B that have not been directly linked to fear memory processes so far.
cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.
Chung et al., Taipei, Taiwan. In Mol Med Report, Jul 2015
In addition, the expression of genes associated with the cell cycle progression were altered, including CCND2, CDKL3 and RASA4, which were upregulated 2.72-, 2.19- and 2.72-fold, respectively; however, CDC42EP3 was downregulated 2.16-fold.
Inactivition of CDKL3 mildly inhibits proliferation of cells at VZ/SVZ in brain.
Tao et al., Dalian, China. In Neurol Sci, Feb 2015
CDKL3 has an important role in regulating cell growth and/or differentiation, and its inactivation is recently reported to be related to non-syndromic mild mental retardation (MR).
A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions.
Jäättelä et al., Copenhagen, Denmark. In Autophagy, 2011
The depletion of MK2, PACSIN1, DAPK2, CDKL3 and SCYL1 functioned upstream of Akt-mTORC1 pathway, whereas CSNK1A1, BUB1, PKLR and NEK4 suppressed autophagosome formation downstream or independent of mTORC1.
Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis.
Zheng et al., Shanghai, China. In Neurobiol Dis, 2010
Here, we investigated the role of the Cdkl3, a mental retardation candidate gene, in neuronal morphogenesis.
Cells by design: a mini-review of targeting cell engineering using DNA microarrays.
Shiloach et al., Baltimore, United States. In Mol Biotechnol, 2008
In a separate example, a gene encoding a mitochondrial assembly protein (cox15) and a gene encoding a kinase (cdkl3), were found to influence cellular growth.
Inactivation of the CDKL3 gene at 5q31.1 by a balanced t(X;5) translocation associated with nonspecific mild mental retardation.
Hanauer et al., Illkirch-Graffenstaden, France. In Am J Med Genet A, 2008
data suggest that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant mild mental retardation
Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog.
Shiloach et al., Bethesda, United States. In Bmc Biotechnol, 2006
cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and faster transition G0/G1 phases to S phase relative to controls. Same in two HEK-293 and a CHO cell lines.
Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas.
Kinney et al., Nashville, United States. In Hum Pathol, 2005
Genes highly expressed in both ALK- and ALK+ ALCLs included kinases (LCK, protein kinase C, vav2, and NKIAMRE) and antiapoptotic molecules, suggesting possible common pathogenetic mechanisms as well.
NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases.
Minden et al., Toronto, Canada. In Biochem Biophys Res Commun, 2003
NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin-dependent kinases
NKIATRE is a novel conserved cdc2-related kinase.
Zanke et al., Toronto, Canada. In Genomics, 2001
NKIATRE also shows close homology to the cyclin-dependent kinase class of protein kinases and the cdc2-related kinases NKIAMRE, KKIALRE, and KKIAMRE, containing both conserved inhibitory phosphorylation sites and a putative cyclin-binding domain.
Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion.
Zanke et al., Toronto, Canada. In Cancer Res, 1999
We have identified NKIAMRE, a novel cyclin-dependent kinase-related molecule that is closely related to the rat serine/threonine kinase NKIATRE.
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