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Killer cell lectin-like receptor subfamily C, member 3

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NKG2A, CD94, NKG2D, MHC, HAD
Papers on NKG2E
Compromised natural killer cells in pulmonary embolism.
Wang et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
RESULTS: In the present study, based on gene expression microarray analysis, we showed four inhibitory receptors (KLRB1, KLRD1, KLRF1, KLRG1) and four activating receptors (KLRC1, KLRC3, KLRK1 and NCR1) on NK cells were remarkably down-regulated and the cytological experiment demonstrated the proportion of CD16+CD56+ NK cells among PBMCs decreased in the PE group.
Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients.
Israni et al., Minneapolis, United States. In Plos One, 2014
The top 5 DEGs with lower levels at week 1 post-transplant were IL7R, KLRC3, CD3E, CD3D, and KLRC2 (Striking Image) compared to baseline.
Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.
Jabri et al., Montréal, Canada. In J Immunol, 2014
The function of NKG2 family member NKG2E is unclear in humans, and its surface expression has never been conclusively established, largely because there is no Ab that binds specifically to NKG2E.
Meta-analysis of gene expression profiles to predict response to biologic agents in rheumatoid arthritis.
Song et al., Seoul, South Korea. In Clin Rheumatol, 2014
p=0.000206) was KLRC3 (Killer Cell Lectin-Like Receptor Subfamily C, Member 3).
Noncontaminated dietary oats may hamper normalization of the intestinal immune status in childhood celiac disease.
Hammarström et al., Umeå, Sweden. In Clin Transl Gastroenterol, 2013
In particular, mRNAs for the regulatory T cell (Treg) signature molecules interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1), the cytotoxicity-activating natural killer (NK) receptors KLRC2/NKG2C and KLRC3/NKG2E, and the tight junction protein claudin-4 remained elevated.
Low gene expression levels of activating receptors of natural killer cells (NKG2E and CD94) in patients with fulminant type 1 diabetes.
Shimomura et al., Suita, Japan. In Immunol Lett, 2013
Using volcano plot analysis, we found reduced expression of killer cell lectin-like receptor subfamily C, member 3 (KLRC3) which encodes NKG2E, a natural killer (NK) cell activating receptor, in fulminant type 1 diabetes, compared with healthy controls.
Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease.
Remmers et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2013
In the current study of Behçet disease (BD), nonsynonymous variants (NSVs) identified by deep exonic resequencing of 10 genes found by GWAS (IL10, IL23R, CCR1, STAT4, KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1RN, NLRP3, MEFV, TNFRSF1A, PSTPIP1, CASP1, PYCARD, NOD2, and TLR4) were evaluated for BD association.
CD94 is essential for NK cell-mediated resistance to a lethal viral disease.
Sigal et al., Philadelphia, United States. In Immunity, 2011
Ectromelia virus-infected cells expressing the major histocompatibility complex (MHC) class Ib molecule Qa-1(b) are specifically recognized by the activating receptor formed by CD94 and NKG2E.
Unliganded estrogen receptor-beta regulation of genes is inhibited by tamoxifen.
Leitman et al., San Francisco, United States. In Mol Cell Endocrinol, 2010
Doxycycline produced a dose-dependent activation of the NKG2E, MSMB and TUB3A genes, which was abolished by tamoxifen.
Development and function of CD94-deficient natural killer cells.
Lanier et al., San Francisco, United States. In Plos One, 2009
The CD94 transmembrane-anchored glycoprotein forms disulfide-bonded heterodimers with the NKG2A subunit to form an inhibitory receptor or with the NKG2C or NKG2E subunits to assemble a receptor complex with activating DAP12 signaling proteins.
The transcriptome of human cytotoxic T cells: similarities and disparities among allostimulated CD4(+) CTL, CD8(+) CTL and NK cells.
Halloran et al., Edmonton, Canada. In Am J Transplant, 2008
NK receptors KLRC1, KLRC3, KLRD1, KLRK1).
A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature.
Miller et al., Minneapolis, United States. In Blood, 2007
These cells, which comprise 19.4% +/- 2.8% of the CD56(dim) NK population in healthy donors, express the activating NKG2D and NKG2E receptors but no KIR or NKG2A.
Multiple transcription factor elements collaborate with estrogen receptor alpha to activate an inducible estrogen response element in the NKG2E gene.
Leitman et al., San Francisco, United States. In Endocrinology, 2007
We previously showed that the killer cell lectin-like receptor (NKG2E) gene is regulated by E2, tamoxifen, and raloxifene.
Genomics and diversity of the common marmoset monkey NK complex.
Walter et al., Göttingen, Germany. In J Immunol, 2007
One exception is the activating NKG2CE gene, which is probably an ancestral form of the NKG2C- and NKG2E-activating receptor genes of humans and great apes.
Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways.
Chan et al., Omaha, United States. In Bmc Genomics, 2006
Numerous genes that may enhance immune function and responsiveness including activating receptors (DNAM1, KLRC1 and KLRC3), death receptor ligand (TNFSF6 (FASL) and TRAIL), chemokine receptors (CX3CR1, CCR5 and CCR7), interleukin receptors (IL2RG, IL18RAB and IL27RA) and members of secretory pathways (DEGS1, FKBP11, SSR3, SEC61G and SLC3A2) were upregulated.
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