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Killer cell lectin-like receptor subfamily K, member 1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: CAN, MICA, MHC, CD8, V1a
Papers using NKG2D antibodies
Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
López-Larrea Carlos et al., In Age, 2002
... elderly participants by staining with anti-CD45, anti-CD3, anti-CD4 (BD Bioscience, San Jose, CA, USA) and anti-NKG2D (eBioscience).
Papers on NKG2D
Phase I study of random, healthy donor-derived allogeneic natural killer cell therapy in patients with malignant lymphoma or advanced solid tumors.
Heo et al., Seoul, South Korea. In Cancer Immunol Res, Feb 2016
Administration of MG4101 augmented NKG2D expression on CD8+ T cells and upregulated chemokines that recruit T cells.
Effect of Indoleamine 2,3-Dioxygenase Expressed in HTR-8/SVneo Cells on Decidual NK Cell Cytotoxicity.
Qu et al., China. In Am J Reprod Immunol, Feb 2016
PROBLEM: To study the effect of indoleamine 2,3-dioxygenase (IDO) expressed in HTR-8/SVneo cells on NKG2D and NKp46 expression and cytotoxicity of decidual NK (dNK) and peripheral NK (pNK) cells.
γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes.
Shevach et al., Bethesda, United States. In J Immunol, Feb 2016
The activated γδ T cells expressed high levels of CD39 and NKG2D on their cell surface.
An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice.
Yu et al., Changchun, China. In Hum Exp Toxicol, Feb 2016
Increased infiltration of natural killer group 2, member D (NKG2D(+)) cells in hair loss skin and upregulated interferon-gamma (IFN-γ) messenger RNA expression in cultured splenocytes were observed in male Balb/c mice.
Impact of NK cells on chronic hepatitis C and hepatocellular carcinoma.
Takehara et al., Suita, Japan. In Hepatol Res, Dec 2015
Recently the role of MHC class I-related chain A (MICA), a human ligand of NKG2D, has attracted attention in the development of HCC.
Microenvironment abnormalities and lymphomagenesis: Immunological aspects.
Gribben et al., London, United Kingdom. In Semin Cancer Biol, Oct 2015
Immunosurveillance effector Natural Killer (NK) cells and Cytotoxic T Lymphocytes (CTL) identify malignant cells through germline receptors such as NKG2D and in the case of CTLs, presentation of antigen through the T cell receptor.
Genetics, genomics, and evolutionary biology of NKG2D ligands.
Bahram et al., Strasbourg, France. In Immunol Rev, Sep 2015
NKG2D (CD314) is an activating receptor expressed on NK cells and subsets of T cells that have a key role in the recognition and lysis of infected and tumor cells.
Comparative genomics of the NKG2D ligand gene family.
Sutoh et al., Sapporo, Japan. In Immunol Rev, Sep 2015
NKG2D ligands (NKG2DLs) are a group of stress-inducible major histocompatibility complex (MHC) class I-like molecules that act as a danger signal alerting the immune system to the presence of abnormal cells.
Distinct mechanisms of tumor resistance to NK killing: of mice and men.
Pardoll, Baltimore, United States. In Immunity, May 2015
Tumors cells can release natural killer (NK) cell ligands for activating receptor NKG2D that are thought to inhibit NK cell function.
Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection.
Raulet et al., Berkeley, United States. In Science, May 2015
It is thought that tumor cells evade immunosurveillance by shedding membrane ligands that bind to the NKG2D-activating receptor on NK cells and/or T cells, and desensitize these cells.
Expression of MICA in oral squamous carcinoma cells and its effect on NK cells.
Liu et al., Fuzhou, China. In Int J Clin Exp Med, 2014
Killing activity of NK92 cells was detected by LDH release method and NKG2D was detected by Flow cytometry.
NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma.
Cippitelli et al., Roma, Italy. In Biomed Res Int, 2014
Enhancement of NK cell-mediated recognition of multiple myeloma cells was reported by us and others showing increased surface expression of NKG2D and DNAM-1 ligands on tumor cells following treatment with a number of chemotherapeutic agents, such as genotoxic drugs or inhibitors of proteasome, histone deacetylases, GSK3, and HSP-90.
Targeted activation of human Vγ9Vδ2-T cells controls epstein-barr virus-induced B cell lymphoproliferative disease.
Tu et al., Hong Kong, Hong Kong. In Cancer Cell, 2014
Herein we showed that the aminobisphosphonate pamidronate-expanded human Vγ9Vδ2-T cells efficiently killed EBV-transformed autologous lymphoblastoid B cell lines (EBV-LCL) through γ/δ-TCR and NKG2D receptor triggering and Fas and TRAIL engagement.
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.
Clynes et al., New York City, United States. In Nat Med, 2014
Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis.
Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.
Lenardo et al., Bethesda, United States. In Science, 2013
We show that decreased intracellular free Mg(2+) causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8(+) T cells and impairs cytolytic responses against EBV.
Ras activation induces expression of Raet1 family NK receptor ligands.
Gasser et al., Singapore, Singapore. In J Immunol, 2012
Upregulation of NKG2D ligands by H-RasV12 increased sensitivity of cells to NK cell-mediated cytotoxicity
Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses.
Salih et al., Tübingen, Germany. In J Immunol, 2012
NKG2DL expression on leukemia cells is relevant for natural kiiller (NK) cell immunosurveillance as well as involvement of soluble NKG2DL in NKG2D downregulation, which results in impaired NK reactivity against leukemia targets.
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
López-Larrea et al., Oviedo, Spain. In Eur J Immunol, 2012
study describes that both N-WASp and WASp participate in the inhibition of NK-cell chemotaxis in response to NKG2D WASp engagement, and that this effect is not dependent on the regulation of F-actin dynamics
Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell.
Lee et al., South Korea. In Cell Immunol, 2012
high killing activity of natural killer cells against K562 was abolished through the addition of a NKG2D blocking antibody
Expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome.
Guida et al., Torino, Italy. In Clin Exp Rheumatol, 2012
Report expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome.
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