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Killer cell lectin-like receptor subfamily C, member 1

NKG2A, NKG2, NK cell receptor
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD94, MHC, NKG2D, KIR, CAN
Papers on NKG2A
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.
Malmberg et al., Stockholm, Sweden. In J Immunol, Feb 2016
Hierarchical clustering of high-resolution immunophenotyping data covering key NK cell parameters, including frequencies of CD56(bright), NKG2A(+), NKG2C(+), and CD57(+) NK cell subsets, as well as the size of the educated NK cell subset, was linked to clinical outcomes.
LIR1 expressing human Natural Killer cell subsets differentially recognize isolates of human cytomegalovirus through the viral MHC Class I homolog UL18.
Wills et al., Cambridge, United Kingdom. In J Virol, Feb 2016
We show that changes in a HCMV viral protein that interacts with an NK cell receptor can change the ability of NK cell subsets to control HCMV while the acquisition odf another receptor has no effect on virus control.
The evolution of natural killer cell receptors.
de Boer et al., Utrecht, Netherlands. In Immunogenetics, Jan 2016
Here, we review the expansion of NKR receptor families in different mammal species, and we discuss several hypotheses that possibly underlie the diversification of the NK cell receptor complex, including the evolution of viral decoys, peptide sensitivity, and selective MHC-downregulation.
Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells.
Velardi et al., Marseille, France. In Haematologica, Jan 2016
Natural Killer cell receptor repertoires are diversified by a stochastic expression of Killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8(+) T-cell recognition of stressed cells.
Sato et al., Sapporo, Japan. In Eur J Immunol, Jan 2016
The induced Qa-1 on the stressed tumor model interacted with an inhibitory NKG2/CD94 receptor on activated CD8(+) T cells and attenuated their specific response to the antigen.
The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8(+) T Cells in Response to a Lethal Poxvirus Infection.
Colonna et al., Saint Louis, United States. In Immunity, Jan 2016
NKG2A, which is encoded by Klrc1, is a lectin-like inhibitory receptor that is expressed as a heterodimer with CD94 on NK cells and activated CD8(+) T cells.
Is parturition-timing machinery related to the number of inhibitor CD94/NKG2A positive uterine natural killer cells?
Yildiran et al., Samsun, Turkey. In Arch Gynecol Obstet, Jan 2016
It is likely that inhibitor CD94/NKG2A positive decidual natural killer cells (uNK) provide for the continuation of pregnancy.
Natural killer cell receptors: alterations and therapeutic targeting in malignancies.
Mirjačić Martinović et al., Belgrade, Serbia. In Immunol Res, Oct 2015
Alterations in NK cell receptor expression and signaling underlie diminished cytotoxic NK cell function.
Antigen-specific NK cell memory in rhesus macaques.
Barouch et al., Boston, United States. In Nat Immunol, Sep 2015
We found that splenic and hepatic NK cells from SHIV(SF162P3)-infected and SIV(mac251)-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques.
Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction.
Colucci et al., Cambridge, United Kingdom. In Immunol Rev, Sep 2015
Invading placental trophoblast cells express human leukocyte antigen class I ligands (HLA-E, HLA-G, and HLA-C) for receptors on maternal uterine natural killer (NK) and myelomonocytic cells, CD94/NKG2, leukocyte immunoglobulin-like receptor (LILR), and killer immunoglobulin receptor (KIR).
NK cells: tuned by peptide?
Khakoo et al., Columbus, United States. In Immunol Rev, Sep 2015
Similarly, the conservation of the NKG2 family of receptors parallels the conservation of MHC-E, the ligand for CD94:NKG2A/C/E.
Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance.
Uhrberg et al., Düsseldorf, Germany. In Cancer Immunol Immunother, Sep 2015
UNASSIGNED: A key feature of human natural killer (NK) cells, which enables efficient recognition of infected and malignant target cells, is the expression of HLA class I-specific receptors of the KIR and NKG2 gene families.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
We aimed to compare intrahepatic and blood NK cell receptor expression to determine the existence of CD49a+ and CXCR6+ NK cells in human liver and define the maturation status of NKG2C+ NK cells at this site.
Downregulation of CD94/NKG2A inhibitory receptor on decreased γδ T cells in patients with systemic lupus erythematosus.
He et al., Beijing, China. In Scand J Immunol, 2012
Results suggested that the low expression level of CD94/NKG2A upon gammadelta T cell activation might lead to the over-activation of gammadelta T cells in patients with SLE.
The adaptor protein Crk controls activation and inhibition of natural killer cells.
Long et al., Rockville, United States. In Immunity, 2012
We imaged primary NK cells over lipid bilayers carrying IgG1 Fc to stimulate CD16 and human leukocyte antigen (HLA)-E to inhibit through receptor CD94-NKG2A.
Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.
Sprent et al., Australia. In Blood, 2011
The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo.
NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti-CD3 antibody.
Herold et al., New Haven, United States. In Eur J Immunol, 2011
The level of NKG2A expression on resting CD8-positive T cells inversely correlated with acquisition of regulatory function when activated.
CD94 is essential for NK cell-mediated resistance to a lethal viral disease.
Sigal et al., Philadelphia, United States. In Immunity, 2011
Because CD94-NKG2 receptors and their ligands are highly conserved in rodents and humans, a similar mechanism may exist during human infections with the smallpox and monkeypox viruses, which are highly homologous to ectromelia virus.
KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during γ-herpesvirus infection.
Flaño et al., Columbus, United States. In J Immunol, 2011
The NKG2A+KLRG1+ positive phenotype correlates with protective efficacy during antigenic recall from a pool of CD8 T cells during persistent gamma-herpesvirus 68 infection.
[Expression of NKG2D and NKG2A with their ligands MHC-I A/B and HLA-E in acute leukemia patients and its significance].
Tang et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
The positive expression rate of NKG2D and NKG2A on NK cells and CD3(+) T cells in ALL patients was no significantly different from that in AML patients.
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