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Tachykinin receptor 2

NK2 receptor, neurokinin-2 receptor, SKR, NK2R, neurokinin A receptor
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, MEN, V1a, ACID, CAN
Papers on NK2 receptor
Gender related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.
Maggi et al., Florence, Italy. In Br J Pharmacol, Feb 2016
BACKGROUND AND PURPOSE: The tachykinin NK2 receptor antagonist ibodutant is under phase III clinical investigation to treat female patients affected by irritable bowel syndrome.
Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats.
Hyslop et al., Campinas, Brazil. In J Pharmacol Exp Ther, Jan 2016
In contrast, mepyramine (a histamine H1 receptor antagonist), D-Arg-[Hyp(3),Thi(5),D-Tic(7),Oic(8)-]-BK (JE 049, a bradykinin B2 receptor antagonist), and ((S)-N-methyl-N-[4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-di-chlorophenyl)butyl]benzamide) (SR48968, a neurokinin NK2 receptor antagonist) had no effect on the venom-induced increase in vascular permeability.
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
Tena-Sempere et al., Córdoba, Spain. In Sci Rep, Dec 2015
Gpr54(-/-)Tg rescued mice showed also altered gonadotropin responses to negative feedback withdrawal, while luteinizing hormone responses to various gonadotropic regulators were variably affected, with partially blunted relative (but not absolute) responses to kisspeptin-10, NMDA and the agonist of tachykinin receptors, NK2R.
The Role of Target Binding Kinetics in Drug Discovery.
IJzerman et al., Leiden, Netherlands. In Chemmedchem, Nov 2015
However, structure-kinetics relationships (SKR) can be very informative too.
Propofol protects against opioid-induced hyperresponsiveness of airway smooth muscle in a horse model of target-controlled infusion anaesthesia.
Matera et al., Roma, Italy. In Eur J Pharmacol, Nov 2015
The inactivation of capsaicin-sensitive sensory nerves via desensitization and blocking NK2 receptor inhibited the BHR remifentanil-induced (P>0.05 vs. controls).
Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD).
Ku et al., Suwŏn, South Korea. In Eur J Med Chem, Oct 2015
μM) showed more potent antiviral activity than ribavirin (EC50 = 1367 μM) and T1105 (EC50 = 347 μM) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain.
Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients.
Pothoulakis et al., Los Angeles, United States. In Cell Mol Gastroenterol Hepatol, Aug 2015
We evaluated the expression levels of SP (Tac-1), NK-1R (Tacr-1), and NK-2R (Tacr-2) mRNA in preadipocytes isolated from patients with Inflammatory Bowel Disease (IBD) and examined their responsiveness to SP compared to control human mesenteric preadipocytes.
Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.
Burgoyne et al., Liverpool, United Kingdom. In Sci Rep, 2014
Transcriptional profiling of these mutants compared to control strains revealed a broad down-regulation of ubiquitin proteasome system (UPS)-related genes, in particular, components of multimeric RING E3 ubiquitin ligases including F-Box, SKR and BTB proteins.
Role of antispasmodics in the treatment of irritable bowel syndrome.
Wittmann et al., Szeged, Hungary. In World J Gastroenterol, 2014
Otilonium bromide is poorly absorbed from the GI tract, where it acts locally as an L-type calcium channel blocker, an antimuscarinic and a tachykinin NK2 receptor antagonist.
Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
Nishimura et al., Sapporo, Japan. In J Immunol, 2012
NK2R-dependent neuropeptide signaling regulates Ag-specific T cell responses via activation of DC function
Tachykinin NK2 receptor antagonists. A patent review (2006 - 2010).
Altamura, Florence, Italy. In Expert Opin Ther Pat, 2012
Tachykinin NK2 receptor antagonists have the potential to be useful in the treatment of various gastrointestinal, genitourinary and CNS diseases.
No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.
Riemenschneider et al., München, Germany. In Neurobiol Aging, 2011
This study demonistrated that no association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.
Expression of the tachykinin receptor mRNAs in healthy human colon.
Imbert et al., Marseille, France. In Eur J Pharmacol, 2009
The prevalence of the TACR2 mRNA alpha isoform strongly suggests a major involvement of tachykinin NK(2) receptor in the regulation of human colonic functions.
Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants.
Lindström et al., Mölndal, Sweden. In Biochem Pharmacol, 2008
polymorphisms leading to the Ile23Thr and Arg375His amino acid exchanges are highly prevalent in the human TACR2 gene, but do affect the potency of the endogenous agonist NKA or small molecule antagonists with respect to intracellular Ca(2+) signalling
Tachykinin receptors and gastrointestinal motility: focus on humans.
Maggi et al., Florence, Italy. In Eur Rev Med Pharmacol Sci, 2008
TKs act at 3 receptors termed as TK NK1 (NK1r), NK2 (NK2r), and NK3 (NK3r) receptors.
Qualitative and quantitative analysis of tachykinin NK2 receptors in chemically defined human colonic neuronal pathways.
Julé et al., Marseille, France. In J Comp Neurol, 2008
NK2 receptors are involved in the neuroneuronal and neuromuscular processes regulating human colonic motility.
Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination.
Shen et al., Stanford, United States. In Science, 2007
We found that stereotyped developmental elimination of synapses in the Caenorhabditis elegans hermaphrodite-specific motor neuron (HSNL) was mediated by an E3 ubiquitin ligase, a Skp1-cullin-F-box (SCF) complex composed of SKR-1 and the F-box protein SEL-10.
Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human.
Maggi et al., Florence, Italy. In Auton Neurosci, 2006
In contrast, in the human colonic smooth muscle, only the NK2 receptor-mediated component of the response to EFS is prominent and some evidence would suggest that this component is the main excitatory motor mechanism at this level.
Relationships between neurokinin receptor-expressing interstitial cells of Cajal and tachykininergic nerves in the gut.
Faussone-Pellegrini, Florence, Italy. In J Cell Mol Med, 2006
Three distinct tachykinin receptors (NK1r, NK2r and NK3r) have been demonstrated by molecular biology.
cDNA cloning of bovine substance-K receptor through oocyte expression system.
Nakanishi et al., Kyoto, Japan. In Nature, 1987
Here we report the isolation of the cDNA clone for bovine substance-K receptor (SKR) by extending this method to develop a new cloning strategy.
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