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Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein

NIP45, NFAT-interacting protein, NFATC2IP
Top mentioned proteins: IL-4, Smt3, Ubiquitin, MAF, TH2
Papers on NIP45
Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization.
Saitoh et al., Kumamoto, Japan. In Biochem Biophys Res Commun, 2013
The nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein, Nfatc2ip (Nip45), has been implicated as a crucial coordinator of the immune response and of cellular differentiation in humans and mice, and contains SUMO-like domains in its C-terminal region.
[Regulatory effects of cyclosporin A and tacrolimus on the immunological gene expressions in renal transplant recipients].
Niu et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2012
RESULTS: The TLR4, CEBPB, IL4R, IL1R1,IL18R1,and IL1R2 genes were remarkably upregulated, whereas IL-2, CCL5, CD27, CCR5, CCR4, CD4, RPL13A, TGFB3, CD86, CCR3, STAT1, NFATC2IP, IL23A, IL15, IRF4, and TFCP2 were downregulated 24 hours after CsA treatment.
NIP45 negatively regulates RANK ligand induced osteoclast differentiation.
Ries et al., Charleston, United States. In J Cell Biochem, 2012
results indicate that RANKL signaling down regulates NIP45 expression and that NIP45 is a negative regulator of osteoclast differentiation
Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.
Xavier et al., Boston, United States. In Blood, 2010
ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes.
Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45.
Shirakawa et al., Kyoto, Japan. In Proteins, 2010
This finding highlights a possible role of the RENi proteins in the modulation of Ubc9-mediated poly-SUMO formation.
NIP45 controls the magnitude of the type 2 T helper cell response.
Mowen et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2010
NIP45 promotes robust cytokine expression in vivo, which is required for the efficient handling of parasites, acting as a molecular rheostat serving to amplify the type-2 immune response.
Novel mutations in a Japanese patient with CD19 deficiency.
Miyawaki et al., Toyama, Japan. In Genes Immun, 2007
The paternal allele was disrupted by a gross deletion encompassing at least the ATP2A1, CD19 and NFATC2IP genes.
SUMO-targeted ubiquitin ligases in genome stability.
Boddy et al., Los Angeles, United States. In Embo J, 2007
The DNA repair factor Rad60 and its human homolog NIP45, which contain SLDs, are candidate STUbL targets.
TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
Tsitsikov et al., Boston, United States. In Int Immunol, 2006
TRAF1 limit the induction of Th2 responses by decreasing NIP45 concentration to the nucleus down-regulating the expression of NIP45-dependent IL-4 gene transcription.
Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family.
Eisenhaber et al., Vienna, Austria. In Bmc Bioinformatics, 2004
Using sequence analytic evidence, we collect family members from animals, fungi and plants, most prominent being yeast Rad60, Esc2 and mouse NIP45
Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1.
MacLennan et al., Birmingham, United Kingdom. In Eur J Immunol, 2004
Soluble recombinant (r)FliC and polymerized FliC are strongly Th2 polarizing, inducing IL-4, NIP45 and c-Maf mRNA as well as epsilon and gamma1 switch transcripts and switching to IgG1.
Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes.
Glimcher et al., Boston, United States. In Mol Cell, 2004
Data report a role for arginine methylation of NIP45 in regulating cytokine gene transcription in the T helper lymphocyte.
Arginine methylation regulates the cytokine response.
Richard et al., Montréal, Canada. In Mol Cell, 2004
The recent identification of the NFAT-interacting protein NIP45 as a methylated protein by marks a new role for protein arginine methylation in lymphocyte signaling and cytokine gene activation.
Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).
Glimcher et al., Boston, United States. In J Exp Med, 2001
Recently we have identified a novel protein NIP45 (nuclear factor of activated T cells [NFAT]-interacting protein) which substantially augments interleukin (IL)-4 gene transcription.
Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements.
Cockerill et al., Adelaide, Australia. In J Immunol, 2000
By reconstituting the activities of both the IL-3 enhancer and its NFAT/Oct element in a variety of cell types, we demonstrated that their T cell-specific activation required the lymphoid cofactors NIP45 and OCA-B in addition to NFAT and Oct family proteins.
NF-AT-Driven interleukin-4 transcription potentiated by NIP45.
Glimcher et al., Boston, United States. In Science, 1997
Designated NIP45 (NF-AT interacting protein), it has minimal similarity to any known genes.
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