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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Reticulon 4 receptor

NgR, Nogo receptor, Nogo-66 receptor
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Nogo, CAN, CD45, MAG, CD13
Papers on NgR
Systemic and tumor-targeted delivery of siRNA by cyclic NGR and isoDGR motif-containing peptides.
Liang et al., Beijing, China. In Biomater Sci, Feb 2016
The cyclic NGR motif and its isomerization product isoDGR recruit CD13 and integrin as their specific receptors, both of which are overexpressed by tumor and neovascular cells.
Evaluation of (188)Re-labeled NGR-VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts.
Wang et al., Xi'an, China. In Tumour Biol, Feb 2016
The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.
NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor.
Schwöppe et al., Münster, Germany. In Oncotarget, Feb 2016
Here we have expressed the model compound tTF-NGR, tTF-TAA, and tTF-LTL with different lengths in the TF domain in E. coli and used these fusion proteins for functional studies in anticancer therapy.
A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro.
Xiao et al., Guangzhou, China. In Mol Cell Neurosci, Jan 2016
UNASSIGNED: The Nogo-66 receptor (NgR1), a receptor for Nogo-A, contributes to the inhibition of axonal regeneration in the adult central nervous system after traumatic injuries.
Experimental and Clinical Advances in Immunotherapy Strategies for Spinal Cord Injury Target on MAIs and Their Receptors.
Wang et al., Chongqing, China. In Curr Pharm Des, Jan 2016
Interestingly, these three structurally different inhibitors share two common receptors, Nogo-66 receptor (NgR) and paired immunoglobulin-like receptor B (PirB), and transduce the inhibitory signal into neurons via their complex combinant and co-receptors, such as p75 neurotrophin receptor (p75NTR), Nogo receptor-interacting protein 1 (LINGO-1), and TROY.
Clinical and metabolic characteristics of treated hyperlipidemic patients additionally affected by subclinical hyperglycemia.
Kautzky-Willer et al., Vienna, Austria. In Lipids Health Dis, Dec 2015
However little is known about differences between treated hyperlipidemic patients (HL) with normal (NGR) or impaired (IGR) glucose regulation.
Multiple Roles for Nogo Receptor 1 in Visual System Plasticity.
McGee et al., Los Angeles, United States. In Neuroscientist, Dec 2015
The nogo-66 receptor 1 (ngr1) is one of only a small number of genes identified thus far that is essential to closing the critical period.
Axon regeneration impediment: the role of paired immunoglobulin-like receptor B.
Fu et al., Beijing, China. In Neural Regen Res, Aug 2015
In addition to the Nogo receptor (NgR), the paired immunoglobulin-like receptor B (PirB) is a recently discovered coreceptor of Nogo, myelin-associated glycoprotein, and myelin oligodendrocyte glycoprotein.
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury.
Silver et al., Cleveland, United States. In Nature, Mar 2015
Protein tyrosine phosphatase σ (PTPσ), along with its sister phosphatase leukocyte common antigen-related (LAR) and the nogo receptors 1 and 3 (NgR), have recently been identified as receptors for the inhibitory glycosylated side chains of CSPGs.
Colon Targeted Liposomal Systems (CTLS): Theranostic Potential.
Jain et al., Sāgar, India. In Curr Mol Med, 2014
RGD, NGR, fibronectin mimetic peptide, and transferrin), Sialyl Lewis X (SLX), low molecular weight ligand like folate, monoclonal antibodies, endostatin gene and sulfatide etc.
PirB is a novel potential therapeutic target for enhancing axonal regeneration and synaptic plasticity following CNS injury in mammals.
Gou et al., Nanchong, China. In J Drug Target, 2014
These MAIs share a common receptor, glycosylphosphatidylinositol-anchored Nogo receptor (NgR).
Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways.
Strittmatter et al., New Haven, United States. In Exp Neurol, 2012
After optic nerve crush injury, transgenic NgR1-deficient neurons regenerate retinal ganglion axons as extensively as do zymosan-injected, macrophage-activated wild-type mice.
NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans.
Giger et al., Ann Arbor, United States. In Nat Neurosci, 2012
The results of this study identify NgR1 and NgR3 as CSPG receptors, suggest that there is functional redundancy among CSPG receptors, and provide evidence for shared mechanisms of MAI and CSPG inhibition.
Nogo-66 receptor activation inhibits neurite outgrowth and increases β-amyloid protein secretion of cortical neurons.
Luo et al., Guangzhou, China. In Mol Med Report, 2012
The overexpression of Nogo-A and the activation of NgR inhibit neurite outgrowth and alter neuronal metabolism, resulting in overproduction and/or release of Abeta, which in turn may trigger the onset and development of AD.
The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1.
Takei et al., Yokohama, Japan. In Biochem Biophys Res Commun, 2012
These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1.
The nogo receptor family restricts synapse number in the developing hippocampus.
Greenberg et al., Boston, United States. In Neuron, 2012
The results of this study suggested that NgR1, a receptor previously shown to restrict axon growth in the adult, also functions in the dendrite as a barrier that limits excitatory synapse number during brain development.
PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Tessier-Lavigne et al., San Francisco, United States. In Science, 2008
Three proteins found in myelin--Nogo, MAG, and OMgp--inhibit axon regeneration in vitro and bind to the glycosylphosphatidylinositol-anchored Nogo receptor (NgR).
Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.
Strittmatter et al., New Haven, United States. In Science, 2005
mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity; physiological NgR signaling from myelin-derived Nogo, MAG, and OMgp consolidates the neural circuitry established during experience-dependent plasticity
P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
He et al., Boston, United States. In Nature, 2002
P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG (myelin-associated glycoprotein) and OMgp
Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.
Strittmatter et al., New Haven, United States. In Science, 2002
Myelin-associated glycoprotein(MAG) binds directly, with high affinity, to NgR; MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury
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