Transcriptional control of spermatogonial maintenance and differentiation.
San Diego, United States. In Semin Cell Dev Biol, 2014
Several transcription factors have been identified that promote spermatogonial differentiation (DMRT1, NGN3, SOHLH1, SOHLH2, SOX3, and STAT3); some of these may influence the decision of an SSC to commit to differentiate while others may promote later spermatogonial differentiation steps.
Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
New York City, United States. In Nat Genet, 2012
Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins(+)) cells that express markers of mature β cells and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas.
Transcriptional regulation of α-cell differentiation.
Philadelphia, United States. In Diabetes Obes Metab, 2011
Many transcription factors, such as neurogenin 3 (Ngn3), pancreatic duodenal homeobox 1 (Pdx1) and regulatory factor x6 (Rfx6), play a crucial role in the determination of the endocrine cell fate, while other transcription factors, such as aristaless-related homeobox (Arx) and forkhead box A2 (Foxa2), are implicated in the initial or terminal differentiation of α-cells.
Rfx6 directs islet formation and insulin production in mice and humans.
San Francisco, United States. In Nature, 2010
During embryonic development, the transcription factor neurogenin 3 (Neurog3) initiates the differentiation of the beta-cells and other islet cell types from pancreatic endoderm, but the genetic program that subsequently completes this differentiation remains incompletely understood.