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NFKB activating protein

NF-kappa B-activating protein
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: GDNF, JNK, AP-1, NF-kappaB, Actin
Papers on NF-kappa B-activating protein
NKAP is required for T cell maturation and acquisition of functional competency.
Shapiro et al., Rochester, United States. In J Exp Med, 2011
NKAP is required for T cell maturation and the acquisition of functional competency
NKAP is a transcriptional repressor of notch signaling and is required for T cell development.
Shapiro et al., Philadelphia, United States. In Immunity, 2009
NKAP functions as a transcriptional repressor, acting on Notch target genes, and is required for alphabeta T cell development.
Identification of a nuclear protein that promotes NF-kappaB activation.
Shu et al., Beijing, China. In Biochem Biophys Res Commun, 2003
NKAP is a novel nuclear regulator of TNF- and IL-1-induced NF-kappaB activation
Act1, an NF-kappa B-activating protein.
Stark et al., Cleveland, United States. In Proc Natl Acad Sci U S A, 2000
Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator.
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