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Sphingomyelin phosphodiesterase 2, neutral membrane

neutral sphingomyelinase, nSMase
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, V1a, CAN, HAD, PrP
Papers on neutral sphingomyelinase
Stimulating the release of exosomes increases the intercellular transfer of prions.
Hill et al., Melbourne, Australia. In J Biol Chem, Feb 2016
Conversely, inhibition of exosome release using GW4869 to target the neutral sphingomyelinase pathway induced a decrease in intercellular prion transmission.
Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells.
Costa et al., Porto, Portugal. In Biochim Biophys Acta, Jan 2016
Here, we show that yeast cells lacking Isc1p, an orthologue of mammalian neutral sphingomyelinase type 2, exhibit vacuolar fragmentation and dysfunctions, namely decreased Pep4p-mediated proteolysis and V-ATPase activity, which impairs vacuolar acidification.
TNFα triggers release of extracellular vesicles containing TNFR1 and TRADD, which can modulate TNFα responses of the parental cells.
Oda et al., Niigata, Japan. In Arch Biochem Biophys, Jan 2016
TNFα-triggered release of EVs was decreased in the presence of amitriptyline, an inhibitor of acid sphingomyelinase (A-SMase), or of GW4869, an inhibitor of neutral sphingomyelinase (N-SMase), indicating that EVs containing TNFR1 and TRADD are released through A-SMase and N-SMase dependent manners.
Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3.
Bieberich et al., Augusta, United States. In Mol Biol Cell, Jan 2016
Ceramide depletion, by myriocin or neutral sphingomyelinase deficiency (fro/fro mouse), led to GSK3 dephosphorylation and defective flagella and cilia.
Role of sphingomyelinases in neurological disorders.
Farooqui et al., Singapore, Singapore. In Expert Opin Ther Targets, Dec 2015
AREAS COVERED: We covered an introduction to sphingomyelinases and its enzymatic product ceramide, in membrane domains or lipid rafts and the nucleus; followed by crosstalk between sphingomyelinase and cytosolic phospholipase A2 (cPLA2) catalysed products including arachidonic acid, functions of acid sphingomyelinase (aSMase) and neutral sphingomyelinase (N-SMase) in neurons, neuronal progenitor cells, glial cells, and brain endothelial cells; alterations in acid and N-SMases in Niemann Pick Disease Type A, major depression, Alzheimer's disease, cerebral ischemia, and pain; and recent developments in identification of inhibitors to sphingomyelinases.
Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis.
Grassme et al., Essen, Germany. In Front Biosci (elite Ed), Dec 2015
We investigated the role of the mammalian neutral sphingomyelinase (Nsm)/ceramide system in systemic infection of mice and murine macrophages with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
Neutral sphingomyelinase and breast cancer research.
Lee et al., Asan, South Korea. In J Menopausal Med, Apr 2015
Our understanding of the functions of neutral sphingomyelinase (N-SMase) signaling has advanced over the past decade.
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
Hannun et al., Stony Brook, United States. In Adv Biol Regul, 2015
In this review, we focus on the roles and regulation of neutral sphingomyelinase 2 (nSMase2), an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin.
Role of Inositol Phosphosphingolipid Phospholipase C1, the Yeast Homolog of Neutral Sphingomyelinases in DNA Damage Response and Diseases.
Tripathi, Mobile, United States. In J Lipids, 2014
This review will also give a new basis for our understanding for the mechanisms and nature of the inositol phosphosphingolipid phospholipase C1/nSMase.
Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity.
Zheng et al., Omaha, United States. In Mol Neurodegener, 2014
The elevated glutaminase was blocked by GW4869, a neutral sphingomyelinase inhibitor known to inhibit MVs release, suggesting a critical role of MVs in mediating glutaminase release.
P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.
Hannun et al., Stony Brook, United States. In Cell Death Dis, 2014
Neutral sphingomyelinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion.
Novel therapeutic and prevention approaches for schistosomiasis: review.
Tallima et al., Cairo, Egypt. In J Advanc Res, 2013
We have proposed an essential fatty acid, a component of our diet and cells, the polyunsaturated fatty acid arachidonic acid (ARA) as a remedy for schistosomiasis, due to its ability to activate the parasite tegument-bound neutral sphingomyelinase, with subsequent hydrolysis of the apical lipid bilayer sphingomyelin molecules, allowing access of specific antibody molecules, and eventual worm attrition.
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
Hannun et al., Charleston, United States. In J Biol Chem, 2011
cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5.
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins.
Remaley et al., Bethesda, United States. In Nat Cell Biol, 2011
Cellular export of miRNAs to HDL was demonstrated to be regulated by neutral sphingomyelinase.
Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.
Goldkorn et al., Davis, United States. In Am J Respir Cell Mol Biol, 2011
nSMase2 has a role in ceramide generation, aberrant apoptosis, and lung injury under cigarette smoke exposure
An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils.
Petty et al., Ann Arbor, United States. In Am J Respir Cell Mol Biol, 2011
N-SMase at the cytofacial plasma membrane is an essential element for the proper orientation of PMNs in FMLP gradients, at least in part by polarizing the distribution of Rac 1/2 and RhoA GTPases.
Aggregated low density lipoprotein induces tissue factor by inhibiting sphingomyelinase activity in human vascular smooth muscle cells.
Llorente-Cortés et al., Barcelona, Spain. In J Thromb Haemost, 2009
inhibition of both A- and N1-Smase might explain the upregulatory effect of agLDL on TF activation, and suggest that this effect is related, at least in part, to membrane SM enrichment.
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.
Mandal et al., Indian Trail, United States. In Mol Cancer, 2009
Results demonstrate that WithaD enhance the ceramide accumulation by activating N-SMase 2, modulate phosphorylation of the JNK and p38MAPK and induced apoptosis in both myeloid and lymphoid cells along with primary cells derived from leukemia patients.
FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.
Krönke et al., Kiel, Germany. In Cell, 1996
This region has been previously recognized as a distinct functional domain that is both required and sufficient for the activation of neutral sphingomyelinase (N-SMase).
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling.
Krönke et al., München, Germany. In Cell, 1994
N-SMase and A-SMase are activated independently by different cytoplasmic domains of TNF-R55.
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