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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Arylacetamide deacetylase-like 1

neutral cholesterol ester hydrolase, NCEH, KIAA1363
Top mentioned proteins: ACID, CAN, HDL, AGE, ESI
Papers on neutral cholesterol ester hydrolase
Macrophage-mediated cholesterol handling in atherosclerosis.
Orekhov et al., Moscow, Russia. In J Cell Mol Med, Jan 2016
Neutral cholesteryl ester hydrolases nCEH and NCEH1 are involved in a secondary hydrolysis of cholesterol esters to liberate free cholesterol that could be then out-flowed from macrophages by cholesterol ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 and SR-BI.
Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics.
Allen Crow et al., United States. In Arch Biochem Biophys, Dec 2015
KIAA1363 is one of the most abundant serine hydrolases in mouse brain.
Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target.
Nomura et al., Berkeley, United States. In Acs Chem Biol, 2015
Using this strategy, we have found that KIAA1363 is a novel target for lowering key pro-inflammatory cytokines through affecting key ether lipid metabolism pathways.
PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.
Cowell et al., Birmingham, United States. In J Neurosci, 2014
We observed bidirectional regulation of novel PGC-1α-dependent transcripts spanning synaptic [synaptotagmin 2 (Syt2) and complexin 1 (Cplx1)], structural [neurofilament heavy chain (Nefh)], and metabolic [neutral cholesterol ester hydrolase 1 (Nceh1), adenylate kinase 1 (Ak1), inositol polyphosphate 5-phosphatase J (Inpp5j), ATP synthase mitochondrial F1 complex O subunit (Atp5o), phytanol-CoA-2hydroxylase (Phyh), and ATP synthase mitrochondrial F1 complex α subunit 1 (Atp5a1)] functions.
Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.
Ishibashi et al., Tokyo, Japan. In J Lipid Res, 2014
In foam cells, these sterols are stored in esterified forms, which are hydrolyzed by two enzymes: neutral cholesterol ester hydrolase 1 (Nceh1) and hormone-sensitive lipase (Lipe).
Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α.
Cowell et al., Birmingham, United States. In Front Cell Neurosci, 2013
We found significant reductions in transcripts with synaptic (complexin1, Cplx1; Pacsin2), structural (neurofilament heavy chain, Nefh), and metabolic (isocitrate dehydrogenase 3a, Idh3a; neutral cholesterol ester hydrolase 1, Nceh1; pyruvate dehydrogenase alpha 1, Pdha1; phytanoyl-CoA hydroxylase, Phyh; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, Uqcrfs1) functions.
Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme.
Ross et al., United States. In Biochemistry, 2013
KIAA1363, another serine hydrolase, was also identified in THP1 cells but did not have significant lipolytic activity.
Foam cells in atherosclerosis.
Tang et al., Hengyang, China. In Clin Chim Acta, 2013
Acyl coenzyme A:cholesterol acyltransferase-1 (ACAT1) and neutral cholesteryl ester hydrolase (nCEH) regulate cholesterol esterification.
A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects.
Di Marzo et al., Pozzuoli, Italy. In Br J Pharmacol, 2013
Competitive activity-based protein profiling confirmed that O-7460 inhibits mouse brain MAGL only at concentrations ≥ 10 μM, and showed that this compound has only one major 'off-target', that is, the serine hydrolase KIAA1363.
Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1).
Kozarich et al., Los Angeles, United States. In Bioorg Med Chem Lett, 2012
KIAA1363 is a serine hydrolase whose activity has been shown to be positively associated with tumor cell invasiveness.
Early steps in reverse cholesterol transport: cholesteryl ester hydrolase and other hydrolases.
Ghosh, Richmond, United States. In Curr Opin Endocrinol Diabetes Obes, 2012
RECENT FINDINGS: New information resulting from the continuing characterization of the various cholesteryl ester hydrolases (hormone-sensitive lipase, HSL; cholesteryl ester hydrolase, CEH; and KIAA1363/NCEH1) is reviewed.
Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients.
Pani et al., Monserrato, Italy. In Lipids Health Dis, 2011
Moreover, when gene expression was evaluated in PBMCs from AD patients and compared with that of PBMCs from healthy subjects of the same age, LDL-R and APP mRNAs were most abundant in AD as compared C1 whereas SREBP-2 and particularly nCEH were present at much lower mRNA levels in AD-PBMCs.
Estrogen-dependent activation of neutral cholesterol ester hydrolase underlying gender difference of atherogenesis in apoE-/- mice.
Tomita et al., Shizuoka, Japan. In Atherosclerosis, 2011
Gender difference of atherogenesis is partly accounted for activation of neutral cholesterol ester hydrolase through estrogen-dependent translocation of A-kinase type II in macrophages.
Role of endoplasmic reticulum neutral lipid hydrolases.
Lehner et al., Edmonton, Canada. In Trends Endocrinol Metab, 2011
In this review we highlight the role of these novel lipases including several members of the carboxylesterase family and enzymes termed arylacetamide deacetylase and KIAA1363/neutral cholesteryl ester hydrolase1/arylacetamide deacetylase-like 1.
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Osuga et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
Nceh1 is involved in the adrenal cholesterol metabolism, and the cholesterol ester hydrolytic activity in adrenal glands is associated with the organ enlargement.
The role of neutral cholesterol ester hydrolysis in macrophage foam cells.
Ishibashi et al., Tokyo, Japan. In J Atheroscler Thromb, 2010
We have recently identified a novel nCEH, neutral cholesterol ester hydrolase 1 (NCEH1), and demonstrated that NCEH1, in addition to LIPE, primarily mediates the hydrolysis of CE in macrophages.
The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.
Ishibashi et al., Tokyo, Japan. In Circ Res, 2010
NCEH1 is expressed in human atheromatous lesions, where it plays a critical role in the hydrolysis of cholesterol ester in human macrophage foam cells, thereby contributing to the initial part of reverse cholesterol transport in human atherosclerosis.
Investigation of low-dose ritonavir on human peripheral blood mononuclear cells using gene expression whole genome microarrays.
McGregor et al., London, United Kingdom. In Genomics, 2010
Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated neutral cholesterol ester hydrolase 1 in 20 healthy individuals.
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Ishibashi et al., Tokyo, Japan. In Cell Metab, 2009
Genetic ablation of Nceh1 promotes foam cell formation and the development of atherosclerosis in mice.
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