GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Neurotrophin 4
neurotrophin-4, NT-4, NT-4/5
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
Brain-derived neurotrophic factor, neurotrophin-3, NGF, TrkB, trkA
Papers on
neurotrophin-4
Olfactory epithelium neural stem cell implantation restores noise-induced hearing loss in rats.
New
Shanghai, China. In Neurosci Lett, Feb 2016
After IL-1β stimulation, nerve growth factor (NGF), neurotrophin-3 (NT-3), and NT-4 levels were evaluated in oe-NSCs.
Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats.
New
Adelaide, Australia. In J Bone Miner Res, Feb 2016
After a drill-hole injury was made in the tibial growth plate and bone, increased injury site mRNA expression was observed for neurotrophins NGF, BDNF, NT-3 and NT-4 and their Trk receptors.
The importance of neuronal growth factors in the ovary.
Review
New
New Haven, United States. In Mol Hum Reprod, Jan 2016
The neurotrophin family consists of nerve growth factor (NGF), neurotrophin 3 (NT3) and neurotrophin 4/5 (NT4/5), in addition to brain-derived neurotrophic factor (BDNF) and the neuronal growth factors, glial cell line-derived neurotrophic factor (GDNF) and vasointestinal peptide (VIP).
Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report.
New
Mercin, Turkey. In Balkan Med J, Oct 2015
Nerve growth factor, neurotrophin 3 (NT-3), neurotrophin 4/5 and brain-derived neurotrophic factor are members of the neurotrophin family.
[Effect of the nerve growth factor mimetic GK-2 on post-resuscitation expression of neurotrophic factors].
New
In Patol Fiziol Eksp Ter, Apr 2015
Immunohistochemical study of proteins FGFb, NT4, BDNF was performed by indirect peroxidase-antiperoxidase method using primary polyclonal antibodies.
Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug.
Siena, Italy. In Sci Rep, 2014
In this paper we report the in vitro and in vivo activity of a new form of paclitaxel, modified for conjugation with a tumor-selective tetrabranched peptide carrier (NT4).
Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions.
Review
New York City, United States. In Trans Am Clin Climatol Assoc, 2014
Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which include nerve growth factor, neurotrophin 3, and neurotrophin 4. Studies over the last three decades have identified mature BDNF as a key regulator of neuronal differentiation, structure, and function; actions mediated by the TrkB receptor.
Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review.
Review
Inch'ŏn, South Korea. In Biomed Res Int, 2014
Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD. Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease.
Neurotrophins and Neuropathic Pain: Role in Pathobiology.
Review
Brisbane, Australia. In Molecules, 2014
nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 and neurotrophin 4. Most research on NTs to date has focussed on the effects of NGF and BDNF signalling via their respective cognate high affinity neurotrophic tyrosine kinase viz TrkA and TrkB receptors.
Neurotrophin regulation of neural circuit development and function.
Review
Impact
Berkeley, United States. In Nat Rev Neurosci, 2013
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function.
Interaction between neurotrophin 4 and gonadotrophin in bovine oviducts.
GeneRIF
Changchun, China. In Theriogenology, 2012
Neurotrophin 4 may have a role in regulating the function of bovine oviducts by interacting with gonadotrophins.
The inorganic perspectives of neurotrophins and Alzheimer's disease.
GeneRIF
Catania, Italy. In J Inorg Biochem, 2012
Studies indicate neurotrophin family comprises nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 , and Zn(2+) and Cu(2+) interactions with them and modulate their activities through conformational changes.
Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons.
GeneRIF
Montpellier, France. In Biochem J, 2012
The results of the present study demonstrate the post-transcriptional up-regulation of the Cav3.2 T-current through TrkB activation and identify NT-4 as a target-derived factor that regulates the mechanosensitive function of D-hair neurons.
Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients.
GeneRIF
Poznań, Poland. In J Neuroimmunol, 2012
NT-4/5 expression is associated with atrophy of the brain-parenchymal fraction measured by magnetic resonance imaging methods in patients with relapsing-remitting multiple sclerosis.
Evaluation of NTF4 as a causative gene for primary open-angle glaucoma.
GeneRIF
Hong Kong, Hong Kong. In Mol Vis, 2011
The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients.
A model for neuronal competition during development.
Impact
Baltimore, United States. In Science, 2008
NGF also controlled expression of brain-derived neurotrophic factor and neurotrophin-4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF-TrkA signaling whereas neurons with high NGF-TrkA signaling are protected.
Neurotrophins mediate human embryonic stem cell survival.
Impact
Baltimore, United States. In Nat Biotechnol, 2006
We show that three TRK ligands, brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4, are survival factors for hES cells.
Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells.
Impact
München, Germany. In Nature, 2003
Full-length receptors (TrkB(FL)) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic factor (BDNF) or neurotrophin 4/5 (NT-4/5).
Trk receptors: roles in neuronal signal transduction.
Review
Impact
San Francisco, United States. In Annu Rev Biochem, 2002
Trk receptors are a family of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).
IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell Survival, Neurogenesis, and Behavioral Outcome
Review
Boca Raton, United States. In Unknown Journal, 0001
After TBI, expression of growth factors such as neurotrophin 4/5, nerve growth factor, basic fibroblast growth factor, brain-derived neurotrophic factor (BDNF), and IGF-1 are increased (Conte et al., 2003; Madathil et al., 2010; Royo et al., 2006).
