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gene encodes a precursor protein for both peptides; neurotensin may be involved in smooth muscle contraction and possibly fat metabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Neuropeptide, ACID, HAD, somatostatin, V1a
Papers on Neurotensin
Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells.
Evers et al., Galveston, United States. In Mol Endocrinol, Jan 2016
Neurotensin (NT) is a 13-amino acid peptide predominantly localized in enteroendocrine cells of the small bowel and released by fat ingestion.
Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand.
Kleczkowska et al., Szeged, Hungary. In Neuropeptides, Jan 2016
UNASSIGNED: Neurotensin (NT) and its analog neuromedin N (NN) are formed by the processing of a common precursor in mammalian brain tissue and intestines.
Neurotensin neural mRNA expression correlates with vocal communication and other highly-motivated social behaviors in male European starlings.
Riters et al., Madison, United States. In Physiol Behav, Dec 2015
Neurotensin (NT) is a neuropeptide implicated in motivation that can modulate the activity of dopaminergic neurons.
1,2,3-Triazole Stabilized Neurotensin-Based Radiopeptidomimetics for Improved Tumor Targeting.
Mindt et al., Basel, Switzerland. In Bioconjug Chem, Nov 2015
Neurotensin (NT) is a regulatory peptide with nanomolar affinity toward NT receptors, which are overexpressed by different clinically relevant tumors.
Computer simulations of sample preconcentration in carrier-free systems and isoelectric focusing in microchannels using simple ampholytes.
Emmer et al., Stockholm, Sweden. In Electrophoresis, Oct 2015
Neurotensin and [Glu1]-Fibrinopeptide B were separated by IEF in microchannels featuring a liquid lid for simple sample handling and placement of the driving electrodes.
Neurotensinergic augmentation of glutamate release at the perforant path-granule cell synapse in rat dentate gyrus: Roles of L-Type Ca²⁺ channels, calmodulin and myosin light-chain kinase.
Lei et al., Grand Forks, United States. In Neuropharmacology, Aug 2015
Neurotensin (NT) serves as a neuromodulator in the brain where it is involved in modulating a variety of physiological functions including nociception, temperature, blood pressure and cognition, and many neurological diseases such as Alzheimer's disease, schizophrenia and Parkinson's disease.
Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p.
Yi et al., Chongqing, China. In Neuro Oncol, Aug 2015
BACKGROUND: Neurotensin (NTS) and its primary receptor NTSR1 are implicated in cancer progression.
Neurotensin immunolabeling relates to sexually-motivated song and other social behaviors in male European starlings (Sturnus vulgaris).
Riters et al., Madison, United States. In Behav Brain Res, May 2015
Neurotensin (NT) is a neuropeptide that strongly modulates dopamine activity, co-localizes with dopamine in VTA, and is found in regions where dopaminergic cells project from VTA.
A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice.
Franken et al., Lausanne, Switzerland. In Plos One, 2014
Pmch, Neurotensin) and in metabolism (e.g.
To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.
Leinninger et al., East Lansing, United States. In Front Syst Neurosci, 2014
Recently, another population of LHA neurons containing the neuropeptide Neurotensin (Nts) has been implicated in coordinating anorectic stimuli and behavior to regulate hydration and energy balance.
Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients.
Yi et al., Chongqing, China. In Mol Cancer, 2014
Neurotensin (NTS) and its high affinity receptor (NTSR1) overexpression induces neoplastic growth and predicts the poor prognosis in various malignancies.
Vinik, Madagascar. In Unknown Journal, 2014
Neurotensin (NT) is a 13 amino acid polypeptide first extracted from bovine brain by Carraway and Leeman(1).
NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease.
Navarro-Quiroga et al., Mexico. In Nanomedicine, 2012
Neurotensin (NTS)-polyplex is a "Trojan horse" synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo.
Intrathecal neurotensin is hypotensive, sympathoinhibitory and enhances the baroreflex in anaesthetized rat.
Pilowsky et al., Sydney, Australia. In Br J Pharmacol, 2012
neurotensin plays an important role in the regulation of spinal cardiovascular function, affecting both tone and adaptive reflexes
Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1.
Pothoulakis et al., Los Angeles, United States. In J Biol Chem, 2012
Endothelin-converting enzyme-1 (ECE-1) degrades NT in acidic conditions, and its activity is crucial for NTR1 recycling.
CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.
Chan et al., Hong Kong, Hong Kong. In Hepatology, 2012
CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors.
Pothoulakis et al., Los Angeles, United States. In Gastroenterology, 2011
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors.
Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum.
Forsberg et al., Kuopio, Finland. In Neurosci Lett, 2011
PREP is not significantly responsible for the in vivo extracellular space cleavage of substance P or neurotensin.
Neurotensin and neuromedin N are differentially processed from a common precursor by prohormone convertases in tissues and cell lines.
Kitabgi, Paris, France. In Results Probl Cell Differ, 2009
Neurotensin (NT) is synthesized as part of a larger precursor that also contains neuromedin N (NN), a six amino acid NT-like peptide.
Leung, Bethesda, United States. In Unknown Journal, 2009
Neurotensin (NT) is a tridecapeptide produced in the hypothalamus (1).
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