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Neuropilin 2

neuropilin-2, NARP, NRP2, NP-2
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Neuropilin-1, vascular endothelial growth factor, CAN, HAD, ACID
Papers on neuropilin-2
Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera.
Zhou et al., Beijing, China. In Chem Biol Interact, Jan 2016
Three proteins neuropilin-2 (NRP2), clusterin (CLU) and A-kinase anchor protein 12 (AKAP12) were up-regulated in the serum-free culture supernatant of T-16HBE-C1 cells.
Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing.
Tran et al., Newark, United States. In Genes Dev, Jan 2016
Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossing commissural axons to mediate floor plate repulsion in the mouse spinal cord.
Differential expression of neurogenes among breast cancer subtypes identifies high risk patients.
Gascón et al., Barcelona, Spain. In Oncotarget, Jan 2016
Histamine receptor1 (HRH1), neuropilin2 (NRP2), ephrin-B1 (EFNB1), neural growth factor receptor (NGFR) and amyloid precursor protein (APP) were differentially overexpressed in basal and HER2-enriched tumor samples and syntaxin 1A (STX1A) was overexpressed in HER2-enriched and luminal B tumors.
Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp.
Chao et al., New York City, United States. In Cell Rep, Jan 2016
The immediate early gene neuronal-activity-regulated pentraxin (NPTX2 or Narp) encodes a protein that has been associated with excitatory synaptogenesis, AMPA receptor aggregation, and the onset of critical periods.
Concurrent Expression of VEGF-C and Neuropilin-2 Is Correlated with Poor Prognosis in Glioblastoma.
Zhu et al., Weifang, China. In Tohoku J Exp Med, Dec 2015
Vascular endothelial growth factor-C (VEGF-C) is a secreted growth factor involved in many oncogenic processes, and neuropilin-2 (NRP2) is essential for neuronal guidance as a well-acknowledged co-receptor of VEGF receptors.
Neuropilins and liver.
Elpek, Antalya, Turkey. In World J Gastroenterol, Jul 2015
Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively.
Neuropilin-1 enforces extracellular matrix signalling via ABL1 to promote angiogenesis.
Raimondi, London, United Kingdom. In Biochem Soc Trans, 2014
Neuropilin-1 (NRP1), together with neuropilin-2, belongs to the neuropilin family.
Molecular mechanisms of homeostatic synaptic downscaling.
Xia et al., New Orleans, United States. In Neuropharmacology, 2014
First the functional roles of several immediate early genes such as Plk2, Homer1a, Arc and Narp are discussed.
Neuropilins: role in signalling, angiogenesis and disease.
Zachary, London, United Kingdom. In Chem Immunol Allergy, 2013
Genetic analysis of the role of NRPs in mice shows that NRP1 is essential for embryonic neuronal pathfinding and cardiovascular development, mediated via semaphorins and VEGF, respectively, while NRP2 has a more restricted role in neuronal patterning and lymphangiogenesis.
[Levator ani trauma after childbirth, from stretch injury to avulsion: review of the literature].
Fritel et al., Paris, France. In Prog Urol, 2013
(NP2) to 86% (NP3).
NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system.
Ruhrberg et al., London, United Kingdom. In Dev Biol, 2012
Loss of NRP2 or its ligand SEMA3F impaired sympathetic gangliogenesis more mildly than loss of SEMA3A/NRP1 signalling, but caused ectopic neurite extension along the embryonic aorta.
The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
Kolodkin et al., Baltimore, United States. In Cell, 2012
The Sema3F receptor neuropilin-2 selectively binds β2Chn, and ligand engagement activates this GAP to ultimately restrain Rac1-dependent effects on cytoskeletal reorganization.
Association study of early-immediate genes in childhood-onset mood disorders and suicide attempt.
Kennedy et al., Toronto, Canada. In Psychiatry Res, 2012
This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248.
Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions.
Nakamoto et al., Aberdeen, United Kingdom. In J Biol Chem, 2012
Nel interacts with a range of molecules through its different domains and exerts distinct functions.
The neuronal EGF-related gene Nell2 interacts with Macf1 and supports survival of retinal ganglion cells after optic nerve injury.
Piri et al., Los Angeles, United States. In Plos One, 2011
It was shown that Nell2 expression at both mRNA and protein levels is localized to retinal ganglion cells. Nell2 had a molecular weight of ~ 140 kDa and 90 kDa, corresponding to the glycosylated and non-glycosylated form, respectively.
Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinal cancer cell lines.
Ellis et al., Houston, United States. In Plos One, 2010
tumor cell-derived NRP-2 mediates critical survival signaling in gastrointestinal cancer cells
Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.
Kolodkin et al., Baltimore, United States. In Nature, 2010
Mice with null mutations in genes encoding Sema3F, and its holoreceptor components neuropilin-2 (Npn-2, also known as Nrp2) and plexin A3 (PlexA3, also known as Plxna3), exhibit increased dentate gyrus (DG) granule cell (GC) and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution.
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
di Tomaso et al., Boston, United States. In N Engl J Med, 2009
METHODS: We determined the expression pattern of vascular endothelial growth factor (VEGF) and three of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vestibular schwannomas associated with neurofibromatosis type 2 and from 22 sporadic schwannomas.
Blocking neuropilin-2 function inhibits tumor cell metastasis.
Bagri et al., San Francisco, United States. In Cancer Cell, 2008
Nrp2, which was originally identified as an axon-guidance receptor, is an attractive target for modulating metastasis.
Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord.
Tessier-Lavigne et al., San Francisco, United States. In Cell, 2000
Several Slit and Semaphorin proteins, expressed in midline and/or ventral tissues, mimic these repellent activities, and midline guidance defects are observed in mice lacking neuropilin-2, a Semaphorin receptor.
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