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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Neuropeptide, nociceptin, orphanin FQ
endogenous ligand of the opioid-like orphan receptor; reduces neuronal excitability and induces an increase in inward rectifying K+ conductance in thalamic neurons [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: neuropeptide Y, V1a, CAN, HAD, ACID
Papers using Neuropeptide antibodies
Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes
Laitinen Jarmo T et al., In BMC Cell Biology, 2000
... CP55940, DAMGO, nociceptin, and SNAP were purchased from Tocris Cookson Ltd ...
Papers on Neuropeptide
The Effects of Antidepressants on Neuropeptide Y in Patients with Depression and Anxiety.
Abdulrezzak et al., Kayseri, Turkey. In Pharmacopsychiatry, Feb 2016
UNASSIGNED: Introduction: This study aimed to investigate the neuropeptide Y (NPY) levels in patients with anxiety and depression and also the effects of antidepressants on this neuropeptide.
Neuropeptide Y input to the rat basolateral amygdala complex and modulation by conditioned fear.
Urban et al., North Chicago, United States. In J Comp Neurol, Feb 2016
UNASSIGNED: Within the basolateral amygdaloid complex (BLA), Neuropeptide Y (NPY) buffers against protracted anxiety and fear.
Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.
Wagner et al., Pomona, United States. In Neuroendocrinology, Feb 2016
Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons.
Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication.
Crabbe et al., Portland, United States. In Behav Brain Res, Feb 2016
Previous studies have identified neuropeptide Y (NPY) as a potential target for modulating alcohol intake.
60 YEARS OF POMC: POMC: an evolutionary perspective.
Cerdá-Reverter et al., Spain. In J Mol Endocrinol, Jan 2016
This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodinorphyn (PDYN) and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event.
Ethanol-induced anxiolysis and neuronal activation in the amygdala and bed nucleus of the stria terminalis.
Wilson et al., Columbia, United States. In Alcohol, Dec 2015
Previous work demonstrates basal anxiety levels in outbred Long-Evans rats correlate with differences in voluntary ethanol consumption and that amygdalar Neuropeptide Y (NPY) systems may play a role in this relationship.
Neuropeptide Y in noradrenergic neurons induces obesity in transgenic mouse models.
Savontaus et al., Turku, Finland. In Neuropeptides, Dec 2015
UNASSIGNED: Neuropeptide Y (NPY) in noradrenergic neurons plays an important role in modulating the release and effects of catecholamines in a prolonged stress response.
[In Process Citation].
Fehér, Budapest, Hungary. In Orv Hetil, Nov 2015
Neuropeptide Y and substance P were thought to play a role in the function of immune cells and in amplification or elimination of the inflammatory processes.
Neuropeptide Y: An Anti-Aging Player?
Cavadas et al., Coimbra, Portugal. In Trends Neurosci, Nov 2015
Accumulating evidence suggests that neuropeptide Y (NPY) has a role in aging and lifespan determination.
Neuropeptide Y (NPY) in tumor growth and progression: Lessons learned from pediatric oncology.
Kitlinska et al., Washington, D.C., United States. In Neuropeptides, Nov 2015
UNASSIGNED: Neuropeptide Y (NPY) is a sympathetic neurotransmitter with pleiotropic actions, many of which are highly relevant to tumor biology.
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
Holsboer et al., Chilly-Mazarin, France. In Nat Rev Drug Discov, 2012
Given the wealth of preclinical data supporting the role of neuropeptides in modulating behaviour, pharmaceutical companies have been attempting to target neuropeptide receptors for over two decades.
Nociceptin is upregulated by FSH signaling in Sertoli cells in murine testes.
Abe et al., Kumamoto, Japan. In Biochem Biophys Res Commun, 2012
these findings may identify nociceptin as a novel paracrine mediator of the FSH effects in the regulation of spermatogenesis.
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Stevens et al., Los Angeles, United States. In Nature, 2012
Unlike the 'classical' opioid receptors, δ, κ and μ (δ-OR, κ-OR and μ-OR), which were delineated by pharmacological criteria in the 1970s and 1980s, the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP, also known as ORL-1) was discovered relatively recently by molecular cloning and characterization of an orphan GPCR.
Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis.
D'Andrea et al., Menlo Park, United States. In Eur J Pharmacol, 2012
Data suggest that nociceptin/nociceptin receptor signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.
Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure.
Roberto et al., Los Angeles, United States. In Biol Psychiatry, 2012
data provide new evidence for an interaction between the nociceptin and CRF systems in the central amygdala
Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture.
Levitan et al., Pittsburgh, United States. In Cell, 2012
Here, Drosophila neuropeptide-containing DCVs are tracked in vivo for minutes with a new method called simultaneous photobleaching and imaging (SPAIM).
Elevated prepronociceptin, nociceptin/orphanin FQ and nocistatin concentrations in rat chronic constriction nerve injury and diabetic neuropathic pain models.
Tachibana et al., Singapore, Singapore. In Neurosci Lett, 2012
This study demonistrated that prepronociceptin, N/OFQ and nocistatin concentrations are significantly altered at different tissues of two rat neuropathy pain models.
Effects of intraplantar nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation.
Parenti et al., Catania, Italy. In Pharmacol Biochem Behav, 2012
Data suggest that peripheral nociceptin/orphanin FQ/NOP receptor/ligand system contributes to abnormal pain sensitivity in inflammatory states.
Munc13 homology domain-1 in CAPS/UNC31 mediates SNARE binding required for priming vesicle exocytosis.
Martin et al., Madison, United States. In Cell Metab, 2011
Neuropeptide and peptide hormone secretion from neural and endocrine cells occurs by Ca(2+)-triggered dense-core vesicle exocytosis.
The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential.
Lambert, Leicester, United Kingdom. In Nat Rev Drug Discov, 2008
Identification of the enigmatic nociceptin/orphanin FQ peptide (N/OFQ) in 1995 represented the first successful use of reverse pharmacology and led to deorphanization of the N/OFQ receptor (NOP).
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