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Neuropeptide FF-amide peptide precursor

neuropeptide FF, NPFF
morphine modulatory neuropeptide involved in nociception and central autonomic regulation [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: Neuropeptide, HAD, NPFF2, CAN, ACID
Papers using neuropeptide FF antibodies
Kisspeptin prevention of amyloid-β peptide neurotoxicity in vitro
Milton Nathaniel G. N., In Journal of Amino Acids, 2011
... Synthetic NPFF, KP, and KSO peptides were obtained from Bachem.
Papers on neuropeptide FF
The action of neuropeptide AF on passive avoidance learning. Involvement of neurotransmitters.
Jászberényi et al., Szeged, Hungary. In Neurobiol Learn Mem, Jan 2016
Neuropeptide AF (NPAF) is an amidated octadecapeptide, which is member of the RFamide peptide family.
Altered nociception and morphine tolerance in neuropeptide FF receptor type 2 over-expressing mice.
Chen et al., Taiwan. In Eur J Pain, Jan 2016
BACKGROUND: The neuropeptide FF system is thought to act as an anti-opioid modulator and plays a role in nociception, morphine antinociception and dependence.
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups.
Nyholt et al., Brisbane, Australia. In Cephalalgia, Jan 2016
CONCLUSIONS: Our results provide novel insight into the likely genes and biological mechanisms that underlie both MA and MO, and when combined with previous data, highlight the neuropeptide FF-amide peptide encoding gene (NPFF) as a novel candidate risk gene for both types of migraine.
Neuropeptide FF Promotes Recovery of Corneal Nerve Injury Associated With Hyperglycemia.
Xie et al., In Invest Ophthalmol Vis Sci, Jan 2016
PURPOSE: To investigate how the neuropeptide FF (NPFF) promotes the recovery of corneal nerve injury associated with hyperglycemia.
Cholesterol-rich lipid rafts are involved in Neuropeptide FF anti-Nociceptin/Orphanin FQ effect.
Zajac et al., Toulouse, France. In J Neurochem, Dec 2015
UNASSIGNED: The participation of a signaling platform to the anti-Nociceptin/Orphanin FQ (N/OFQ) effect of Neuropeptide FF (NPFF) receptors was investigated in both acutely dissociated neurons and SH-SY5Y human neuroblastoma cells.
Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice.
Wang et al., Lanzhou, China. In Eur J Pharmacol, Dec 2015
Neuropeptide FF (NPFF) system has recently been reported to modulate cannabinoid-induced antinociception.
The effect of neuropeptide FF in the amygdala kindling model.
Boon et al., Gent, Belgium. In Acta Neurol Scand, Nov 2015
OBJECTIVE: Neuropeptide FF (NPFF) and its receptors (NPFF1 R and NPFF2 R) are differentially distributed throughout the central nervous system.
Rapid Covalent Fluorescence Labeling of Membrane Proteins on Live Cells via Coiled-Coil Templated Acyl Transfer.
Seitz et al., Berlin, Germany. In Bioconjug Chem, Nov 2015
We demonstrate the versatility of this method by applying it to the labeling of different G-protein coupled membrane receptors including the human neuropeptide Y receptors 1, 2, 4, 5, the neuropeptide FF receptors 1 and 2, and the dopamine receptor 1.
Effects of direct QRFP-26 administration into the medial hypothalamic area on food intake in rats.
Lénárd et al., Pécs, Hungary. In Brain Res Bull, Sep 2015
GPR103 receptors share amino acid identity with other receptors of neuropeptides involved in feeding (NPY, NPFF, galanin).
RFamide peptides in agnathans and basal chordates.
Tsutsui et al., Ōsaka, Japan. In Gen Comp Endocrinol, Jul 2015
In vertebrates, the RFamide peptide family includes gonadotropin-inhibitory hormone (GnIH), neuropeptide FF (NPFF), prolactin-releasing peptide (PrRP), pyroglutamylated RFamide peptide/26RFamide peptide (QRFP/26RFa), and kisspeptins (kiss1 and kiss2).
An evolutionary scenario for gonadotrophin-inhibitory hormone in chordates.
Tsutsui et al., Tokyo, Japan. In J Neuroendocrinol, Jun 2015
From a structural point of view, pain modulatory neuropeptides, such as neuropeptide FF (NPFF) and neuropeptide AF, share a C-terminal PQRFamide motif.
Evolution of gonadotropin-inhibitory hormone receptor and its ligand.
Tsutsui et al., Tokyo, Japan. In Gen Comp Endocrinol, 2015
GPR147 is also named neuropeptide FF (NPFF) receptor 1 (NPFFR1), because it also binds NPFF that has a C-terminal PQRFamide motif.
Involvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in Rodents.
Simonin et al., Illkirch-Graffenstaden, France. In Front Endocrinol (lausanne), 2013
They act through five G-protein-coupled receptors and each group of peptide binds to and activates mostly one receptor: RF-amide related peptide group binds to NPFFR1, neuropeptide FF group to NPFFR2, pyroglutamylated RF-amide peptide group to QRFPR, prolactin-releasing peptide group to prolactin-releasing peptide receptor, and kisspeptin group to Kiss1R.
Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?
Seong et al., Seoul, South Korea. In Front Endocrinol (lausanne), 2013
Because of the Arg-Phe (RF) sequence at its carboxyl terminus, KISS has been proposed to be a member of the RF-amide peptide family consisting of neuropeptide FF (NPFF), neuropeptide VF (NPVF), pyroglutamylated RF-amide peptide (QRFP), and prolactin-releasing hormone (PRLH).
FMRFamide-related peptide expression in the vestibular-afferent neurons.
Vega et al., Puebla de Zaragoza, Mexico. In Neurosci Lett, 2012
the ASIC are tonically active in the vestibular-afferent neurons and modulated by RFamide-like peptides
Vasopressin (VP) and neuropeptide FF (NPFF) systems in the normal and hypertensive human brainstem.
Swaab et al., Amsterdam, Netherlands. In J Comp Neurol, 2011
reduction of NPFF release within the dorsal motor nucleus and ambiguus nucleus could serve as a possible cause of the impairment of cardiac vagal control in hypertensive patients
Central locomotor and cognitive effects of a NPFF receptor agonist in mouse.
Mouledous et al., France. In Peptides, 2010
results demonstrate a small but complex influence of the NPFF system on mouse behavior
Neuropeptide FF (NPFF) reduces the expression of cocaine-induced conditioned place preference and cocaine-induced sensitization in animals.
Silberring et al., Lublin, Poland. In Peptides, 2008
Npff reduces the expression of cocaine-induced conditioned place preference and cocaine-induce sensitization in mice.
Modulatory role of neuropeptide FF system in nociception and opiate analgesia.
Iadarola et al., Bethesda, United States. In Neuropeptides, 2008
the findings from the early studies on the analgesic and morphine modulating activities suggested a role for NPFF in pain modulation--review
A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.
Anderson et al., Pasadena, United States. In Cell, 2001
Some of these receptors can be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF, which are analgesic in vivo.
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