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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Tachykinin 2

neurokinin B, NKB
putative tachykinin protein [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, Neuropeptide, Gonadotropin-Releasing Hormone, kisspeptin, V1a
Papers on neurokinin B
Regulation of gene expression by 17β-estradiol in the arcuate nucleus of the mouse through ERE-dependent and ERE-independent mechanisms.
Roepke et al., New Brunswick, United States. In Steroids, Feb 2016
Furthermore, the NKB receptor, Tac3r, was suppressed by E2B in WT and KIKO females but not ERKO females, suggesting that ERα-dependent, ERE-independent signaling is necessary for Tac3r regulation.
The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder.
Al-Ayadhi et al., Cairo, Egypt. In Metab Brain Dis, Feb 2016
UNASSIGNED: Tachykinins (substance P, neurokinin A, and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases, including autism spectrum disorder (ASD).
Immunoelectron microscopic observation of the subcellular localization of kisspeptin, neurokinin B and dynorphin A in KNDy neurons in the arcuate nucleus of the female rat.
Ozawa et al., Tokyo, Japan. In Neurosci Lett, Jan 2016
UNASSIGNED: KNDy neurons are named for their co-expression of three neuropeptides, kisspeptin, neurokinin B (NKB) and dynorphin A (DynA).
Different Medications for Hypogonadotropic Hypogonadism.
Maggi et al., In Endocr Dev, Dec 2015
Other molecules, such as kisspeptin and neurokinin B agonists, are now under evaluation as new therapeutic options for treating DP.
Genetics of Hypogonadotropic Hypogonadism.
Kotan et al., In Endocr Dev, Dec 2015
Also, discovery of mutations in KISS1/KISS1R and TAC3/TACR3 in kisspeptin and neurokinin B signaling, respectively, has provided major advancements in our understanding of the biology of the gonadotropin-releasing hormone pulse generator.
Therapeutic Neuroendocrine Agonist and Antagonist Analogs of Hypothalamic Neuropeptides as Modulators of the Hypothalamic-Pituitary-Gonadal Axis.
Millar et al., In Endocr Dev, Dec 2015
The novel neuroendocrine peptides, kisspeptin (KP) and neurokinin B (NKB), were recently discovered as upstream regulators of GnRH, and inactivating mutations of KP and NKB ligands or receptors result in a failure to progress through puberty.
A direct neurokinin B projection from the arcuate nucleus regulates magnocellular vasopressin cells of the supraoptic nucleus.
Leng et al., Cape Town, South Africa. In J Neuroendocrinol, Dec 2015
UNASSIGNED: Central administration of neurokinin B (NKB) agonists stimulates immediate early gene expression in the hypothalamus and increases secretion of vasopressin from the posterior pituitary through a mechanism that depends on the activation of neurokinin receptor 3 receptors (NK3R).
[Effects of Suspending Moxibustion at "Dazhui" (GV 14) on Neurogenic Inflammation in Asthma Rats].
Xiong et al., In Zhen Ci Yan Jiu, Oct 2015
OBJECTIVE: To observe the effect of suspending-moxibustion stimulation of "Dazhui" (GV 14) with different quantities on the levels of nerve growth factor(NGF) , substance P(SP) , calcitonin gene-related peptide (CGRP), neurokinin A (NKA) , neurokinin B (NKB) and phosphorylated extracellular signal-regulated kinases (pERK) in the bronchoalveolar lavage fluid (BALF) of asthma rats, so as to analyze its mechanisms underlying improving asthma.
Physiology of Gnrh and Gonadotropin Secretion
George et al., Madagascar. In Unknown Journal, Aug 2015
Translational clinical studies, exploring kisspeptin and neurokinin B activity in various physiological and pathological states are pivotal to potential clinical applications for these novel neuropeptides and their agonists as well as antagonists.
Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders.
Jayasena et al., London, United Kingdom. In Endocrinol Metab (seoul), Jun 2015
Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation.
Role of a neurokinin B receptor antagonist in the regulation of ovarian function in healthy women.
Anderson et al., Edinburgh, United Kingdom. In Lancet, Mar 2015
BACKGROUND: Patients with loss-of-function mutation in neurokinin B (NKB) and its receptor show hypogonadotropic hypogonadism characterised by failure to progress through puberty, indicating the involvement of this newly described hypothalamic peptide in human reproduction.
High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in puberty-advanced female rats.
O'Byrne et al., London, United Kingdom. In Endocrinology, 2012
Data suggest that the earlier accelerated GnRH pulse generator frequency and advanced puberty with obesogenic diets might be associated with premature up-regulation of kisspeptin and NKB signaling in the hypothalamus of the female rat.
Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.
Rance et al., Tucson, United States. In Endocrinology, 2012
Data show that arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons are essential for tonic gonadotropin secretion, the rise in LH after removal of E(2), and the E(2) modulation of body weight.
Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract.
Candenas et al., Sevilla, Spain. In Fertil Steril, 2012
NKB/NK(3)R and kisspeptin/KISS1R are present in female peripheral reproductive tissues with colocalization of both systems in some non-neuronal cell populations of the human female genital tract.
Inactivating KISS1 mutation and hypogonadotropic hypogonadism.
Yuksel et al., Adana, Turkey. In N Engl J Med, 2012
Inactivating mutations in the genes encoding the human kisspeptin receptor (KISS1R, formerly called GPR54), neurokinin B (TAC3), and the neurokinin B receptor (TACR3) result in pubertal failure.
Role of neurokinin B in the control of female puberty and its modulation by metabolic status.
Tena-Sempere et al., Córdoba, Spain. In J Neurosci, 2012
Neurokinin B-neurokinin 3 receptor signaling plays a role in pubertal maturation; its alterations may contribute to pubertal disorders linked to metabolic stress and negative energy balance.
Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system.
Ma et al., Boston, United States. In Mol Brain, 2011
Tac2 homozygous null mice responded normally to a series of algogenic (pain-inducing) and pruritic (itch-inducing) stimuli.
The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges.
Moenter et al., Charlottesville, United States. In Endocr Rev, 2010
Here we review the current knowledge of the neurobiology of the GnRH surge, in particular the actions of estradiol on GnRH neurons and their synaptic afferents, the regulation of GnRH neurons by fast synaptic transmission mediated by the neurotransmitters gamma-aminobutyric acid and glutamate, and the host of excitatory and inhibitory neuromodulators including kisspeptin, vasoactive intestinal polypeptide, catecholamines, neurokinin B, and RFamide-related peptides, that appear essential for GnRH surge regulation, and ultimately ovulation and fertility.
Kisspeptin signaling in the brain.
Steiner et al., Seattle, United States. In Endocr Rev, 2009
Kisspeptin neurons are sexually differentiated with respect to cell number and transcriptional activity in certain brain nuclei, and some kisspeptin neurons express other cotransmitters, including dynorphin and neurokinin B (whose physiological significance is unknown).
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.
Semple et al., Adana, Turkey. In Nat Genet, 2009
Neurokinin B is a critical central regulator of human gonadal function.
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