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Sialidase 1

Neuraminidase, sialidase
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, CD45
Papers using Neuraminidase antibodies
Temporal resolution of protein–protein interactions in the live-cell plasma membrane
Schütz Gerhard J. et al., In Biochimica et Biophysica Acta, 2009
... Trypan Blue and neuraminidase were purchased from Sigma Aldrich (Schnellendorf, Germany) ...
Avian influenza receptor expression in H5N1-infected and noninfected human tissues
Nahm Sang-Soep et al., In Journal of Veterinary Science, 2007
... out either by omitting the lectin incubation or by pre-incubating the tissue sections with recombinant neuraminidase cloned from Clostridium perfringens (12.5 U/µL; New England Biolabs, USA) at 37℃ for ...
Human monoclonal antibody combination against SARS coronovirus: Synergy and coverage of escape mutants.
Park Man-Seong, In PLoS ONE, 2005
... Briefly, the hemagglutinin (HA) and neuraminidase (NA) genes of H5N1 viruses from clades 0, 1, 2.1, 2.2, 2.3, 4, 7 and 8 (Table 1) were synthesized (GenScript, USA) based on the ...
Papers on Neuraminidase
Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform.
Neufeld et al., Kingston, Canada. In Biomater Sci, Feb 2016
We recently reported that oseltamivir phosphate targets and inhibits Neu1 sialidase activity associated with receptor tyrosine kinases such as epidermal growth factor receptors (EGFRs) which are overexpressed in cancer cells.
The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.
Govorkova et al., Memphis, United States. In Antimicrob Agents Chemother, Feb 2016
A single therapeutic dose of VIS410 given 24 h after virus inoculation resulted in dose-dependent protection of up to 100% of mice inoculated with neuraminidase inhibitor-susceptible or -resistant A(H7N9) viruses.
Virus Susceptibility and Clinical Effectiveness of Anti-influenza Drugs During the 2010-2011 Influenza Season in Russia.
Maleev et al., Moscow, Russia. In Int J Infect Dis, Feb 2016
Here we determined in vitro susceptibility of influenza A and B viruses isolated in 2010-2011 season in Russia to the neuraminidase inhibitor oseltamivir and the hemagglutinin fusion inhibitor umifenovir.
Design, synthesis, and biological evaluation of crenatoside analogues as novel influenza neuraminidase inhibitors.
Zeng et al., Changsha, China. In Eur J Med Chem, Feb 2016
UNASSIGNED: Natural products, especially derived from TCMH, have been found to exert antiviral effects against influenza virus.
Influenza in the Emergency Department: Vaccination, Diagnosis, and Treatment: Clinical Practice Paper Approved by American Academy of Emergency Medicine Clinical Guidelines Committee.
Coyne et al., San Diego, United States. In J Emerg Med, Feb 2016
Treatment with neuraminidase inhibitors can decrease the duration of influenza and is recommended in hospitalized patients, or in those with high risk of complications.
Sialylation: an Avenue to Target Cancer Cells.
Patel et al., Ahmadābād, India. In Pathol Oncol Res, Jan 2016
The alterations in sialylation is accompanied by changes in sialic acid, sialidase activity, sialyltransferase (ST) activity or sialoproteins.
New small-molecule drug design strategies for fighting resistant influenza A.
Wang et al., Shanghai, China. In Acta Pharm Sin B, Sep 2015
Two major classes of anti-influenza drugs currently available are admantane-based M2 protein blockers (amantadine and rimantadine) and neuraminidase (NA) inhibitors (oseltamivir, zanamivir, and peramivir).
What Adaptive Changes in Hemagglutinin and Neuraminidase Are Necessary for Emergence of Pandemic Influenza Virus from Its Avian Precursor?
Matrosovich et al., Moscow, Russia. In Biochemistry (mosc), Jul 2015
By analyzing the earliest available pandemic influenza viruses (1918, 1957, 1968, 2009), we found that hemagglutinin reconfigured to recognize 2-6 sialic acid-containing receptors in the human upper airway tract together with altered enzymatic activity of neuraminidase necessary for maintaining functional balance with hemagglutinin are responsible for effective spread of influenza viruses in human populations.
Multidimensional Analysis of Hippocampal Excitatory Neurotransmission and Development of Analytical Tools for Glycans.
Minami, Shizuoka, Japan. In Yakugaku Zasshi, 2014
Since sialic acid plays crucial roles in synaptic plasticity and memory in the hippocampus, the regulation of sialyl signaling by sialidase is also necessary for neural functions.
Influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza annual report, 2014.
Kelso et al., Melbourne, Australia. In Commun Dis Intell Q Rep, 2014
A small number of A(H1N1)pdm09 and B/Victoria viruses had highly reduced inhibition to the neuraminidase inhibitors oseltamivir and zanamivir.
Mechanism of Tc toxin action revealed in molecular detail.
Raunser et al., Dortmund, Germany. In Nature, 2014
The structures reveal that, in addition to a translocation channel, TcA forms four receptor-binding sites and a neuraminidase-like region, which are important for its host specificity.
Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study.
Shu et al., Nanchang, China. In Lancet, 2014
The virus was sensitive to neuraminidase inhibitors.
Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens.
Sonnenburg et al., Stanford, United States. In Nature, 2013
Colonization of gnotobiotic mice with a sialidase-deficient mutant of Bacteroides thetaiotaomicron, a model gut symbiont, reduces free sialic acid levels resulting in C. difficile downregulating its sialic acid catabolic pathway and exhibiting impaired expansion.
Characterization of H7N9 influenza A viruses isolated from humans.
Kawaoka et al., Saitama, Japan. In Nature, 2013
Anhui/1 was found to be less sensitive in mice to neuraminidase inhibitors than a pandemic H1N1 2009 virus, although both viruses were equally susceptible to an experimental antiviral polymerase inhibitor.
Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance.
Yuan et al., Shanghai, China. In Lancet, 2013
We also sequenced viral RNA from these specimens to study the mutations associated with resistance to neuraminidase inhibitors and their association with disease outcome.
NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not.
Goldblum et al., Baltimore, United States. In J Biol Chem, 2012
Data show that NEU1 was immunolocalized to both the plasma membrane and the perinuclear region, and NEU3 was detected both in the cytosol and nucleus.
NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling.
Goldblum et al., Baltimore, United States. In J Biol Chem, 2012
human airway epithelia express catalytically active NEU1 sialidase that regulates EGFR- and MUC1-dependent signaling and bacterial adhesion.
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling.
Szewczuk et al., Kingston, Canada. In J Biol Chem, 2011
a novel Neu1 and MMP9 cross-talk in alliance with TLR4 on the cell surface that is essential for ligand activation of TLRs and subsequent cellular signaling.
Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors.
Hinek et al., Montréal, Canada. In Glycoconj J, 2011
Neuraminidase 1 as a modulator of cell receptors. (Review)
Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1.
Cross et al., Baltimore, United States. In J Leukoc Biol, 2011
colocalized with CD18 in PMNs; could be a physiologic source of the enzymatic activity that removes sialyl residues on beta2 integrin and ICAM-1, resulting in their enhanced interaction
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