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Neudesin neurotrophic factor
Neudesin, CIR-2
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009] (from
NCBI)
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Top mentioned proteins:
C1r, V1a, HAD, CAN, MAPK
Papers on
Neudesin
Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis.
Review
Kōbe, Japan. In Front Mol Biosci, 2014
Neudesin was originally identified as a secreted protein with neurotrophic activity, and, thereafter, was also termed neuron-derived neurotrophic factor (NENF) or the candidate oncogene GIG47.
Neudesin is involved in anxiety behavior: structural and neurochemical correlates.
Braga, Portugal. In Front Behav Neurosci, 2012
Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor.
Neurotrophic effects of neudesin in the central nervous system.
Kyoto, Japan. In Front Neurosci, 2012
Neudesin (neuron-derived neurotrophic factor; NENF) was identified as a neurotrophic factor that is involved in neuronal differentiation and survival.
The Saccharomyces cerevisiae Genes, AIM45, YGR207c/CIR1 and YOR356w/CIR2, Are Involved in Cellular Redox State Under Stress Conditions.
Braga, Portugal. In Open Microbiol J, 2009
In this work, we investigated phenotypes of the yeast mutants affected in the orthologous genes of the matrix heterodimer (AIM45 and YGR207c/CIR1) and of the electron transfer flavoprotein dehydrogenase (YOR356w/CIR2).
Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade.
GeneRIF
Chiba, Japan. In Biochem Biophys Res Commun, 2009
These findings suggest that neudesin plays a critical role in the early stage of adipocyte differentiation in which C/EBPbeta induces PPARgamma and C/EBPalpha expressions, by controlling the MAPK pathway.
Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain.
GeneRIF
Chiba, Japan. In J Biol Chem, 2008
Neudesin is the first extracellular heme-binding protein that shows signal transducing activity by itself. The present findings may shed new light on the function of extracellular heme-binding proteins
Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells.
GeneRIF
Kyoto, Japan. In J Neurosci Res, 2006
The present findings have revealed new potential roles of neudesin in neural cell proliferation and neuronal differentiation.
Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection.
Tübingen, Germany. In Electrophoresis, 2006
They include decreased cytochrome b5 and transgelin, and more abundant CRABP-II, cyclophilin A, Neudesin, and hemoglobin in ER+/PR+ tumors versus ER+/PR- providing a possible explanation for differential susceptibility against tamoxifen as a result of deregulated cytochrome b5-dependent metabolism.
Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity.
GeneRIF
Kyoto, Japan. In J Neurosci Res, 2005
identification of neudesin, a novel mouse secreted protein showing neurotrophic activity in primary cultured mouse neurons
Drought tolerance established by enhanced expression of the CC-NBS-LRR gene, ADR1, requires salicylic acid, EDS1 and ABI1.
Edinburgh, United Kingdom. In Plant J, 2004
This was not a general feature of defence-related mutants because cir (constitutive induced resistance)1, cir2 and cpr (constitutive expressor of PR genes)1, which constitutively express systemic acquired resistance (SAR), failed to exhibit this phenotype.
Identification of long intergenic repeat sequences associated with DNA methylation sites in Caulobacter crescentus and other alpha-proteobacteria.
Stanford, United States. In J Bacteriol, 2003
The CIR1 and CIR2 motifs exhibit a conserved inverted repeat organization, with a CcrM site in the center of one of the repeats.
Targeting of T cells to CEA-expressing tumor cells by chimeric immune receptors with a highly specific single-chain anti-CEA activity.
Fukuoka, Japan. In Anticancer Res, 2002
The resulting CIR gene, termed F39scFv/CIR-2, was transfected into human T cells.
Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines.
Hamilton, Canada. In Oncogene, 1998
Two transcripts, denoted CIR1 and CIR2, were identified which were up-regulated in immortal cells.
Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.
Brisbane, Australia. In Mol Endocrinol, 1998
The present investigation demonstrates that two corepressor interaction regions, CIR-1 and CIR-2, separated by approximately 150 amino acids in the E region of RVR, are required for the interaction with N-CoR, RIP13a, and RIP13 delta A. The D region is not required for the physical interaction.
An operator associated with autoregulation of the repressor gene in actinophage phiC31 is found in highly conserved copies in intergenic regions in the phage genome.
Glasgow, United Kingdom. In Nucleic Acids Res, 1994
CIR-1 containing fragments were retarded in electrophoresis gels by the 42 kDa repressor protein isoform and this retardation was inhibited by the addition of competing DNA fragments containing either CIR-1 or CIR-2.
