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Spectrin repeat containing, nuclear envelope 2

nesprin-2, NUA, Syne-2
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CPG2, Actin, CAN, SUN2, V1a
Papers on nesprin-2
Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat.
Robbins et al., Wilmington, United States. In Mol Hum Reprod, Jan 2016
Associated loci contain potentially functional minor alleles (0.25-0.36 in tested rat strains) including an exonic deletion in Syne2, a large intronic insertion in Ncoa4 (an AR coactivator) and potentially deleterious variants in Solh/Capn15, Ankrd28, and Hsd17b2.
Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer.
Matsuura et al., Suita, Japan. In Cancer Med, Oct 2015
Using immunohistology, we found that a nuclear lamina component, lamin A/C and all of the investigated LINC complex components, SUN1, SUN2, and nesprin-2, were downregulated in human breast cancer tissues.
mRNA encoding Sec61β, a tail-anchored protein, is localized on the endoplasmic reticulum.
Palazzo et al., Toronto, Canada. In J Cell Sci, Oct 2015
Here, we provide evidence that a subset of mRNAs encoding tail-anchored proteins, including Sec61β and nesprin-2, is partially localized to the surface of the ER in mammalian cells.
Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.
Egelhoff et al., Cleveland, United States. In J Cell Biol, Sep 2015
We further demonstrate that the nuclear membrane protein nesprin-2 is a possible linker coupling NMIIB-based force generation to nuclear translocation.
Sun1 deficiency leads to cerebellar ataxia in mice.
Chi et al., Taiwan. In Dis Model Mech, Sep 2015
Results of immunohistochemical analyses suggested that Sun1 is highly expressed in Purkinje cells and recruits Syne2 to the periphery of the nucleus.
Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC.
Keavney et al., Newcastle upon Tyne, United Kingdom. In J Mol Cell Cardiol, Aug 2015
The analyses in peripheral blood showed association between AF risk SNPs and decreased expression of KCNN3 (0.85-fold; p=2.1×10(-4)); and increased expression of SYNE2 (1.12-fold; p=7.5×10(-24)); however, these associations were not detectable in atrial tissue.
A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.
Nishina et al., Bar Harbor, United States. In Invest Ophthalmol Vis Sci, Jun 2015
RESULTS: The cpfl8 mutation was mapped to Chromosome 12, and a premature stop codon was identified in the spectrin repeat containing nuclear envelope 2 (Syne2) gene.
Quantification of Niacin and Its Metabolite Nicotinuric Acid in Human Plasma by LC-MS/MS: Application to a Clinical Trial of a Fixed Dose Combination Tablet of Niacin Extended-Release/Simvastatin (500 mg/10 mg) in Healthy Chinese Volunteers.
Gu et al., Shenyang, China. In Int J Anal Chem, 2014
Our paper aimed to develop rapid, sensitive, and specific LC-MS/MS method for the quantification of niacin (NA) and its metabolite nicotinuric acid (NUA) in human plasma.
Comparative analysis of blood and saliva expression profiles in chronic and refractory periodontitis patients.
He et al., Wuhan, China. In Bmc Oral Health, 2014
In addition, CD24, EST1, MTSS1, ING3, CCND2 and SYNE2 might be potential targets for diagnosis and treatment of CP.
Epigenetic Dysregulation in the Prefrontal Cortex of Suicide Completers.
Haaf et al., Germany. In Cytogenet Genome Res, 2014
Although, in general, there was no significant overlap between different published data sets or between our top 1,000 DMRs and published data sets, our methylation screen strengthens a number of candidate genes (APLP2, BDNF, HTR1A, NUAK1, PHACTR3, MSMP, SLC6A4, SYN2, and SYNE2) and supports a role for epigenetics in the pathophysiology of suicide.
Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement.
Gundersen et al., New York City, United States. In Cell Cycle, 2014
Recently, we discovered that the diaphanous formin family member FHOD1 interacts with the LINC complex component nesprin-2 giant (nesprin-2G) and that this interaction plays essential roles in the formation of transmembrane actin-dependent nuclear (TAN) lines and nuclear movement during cell polarization in fibroblasts.
FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement.
Gundersen et al., Heidelberg, Germany. In Nat Cell Biol, 2014
This nuclear movement depends on nesprin-2 giant (N2G), a large, actin-binding outer nuclear membrane component of transmembrane actin-associated (TAN) lines that couple nuclei to moving actin cables.
Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA.
Meier et al., Columbus, United States. In Plant Mol Biol, 2012
Data suggest that NUA scaffolds AtMAD1 and AtMAD2 at the nuclear pore to form a functional complex and that both NUA and AtMAD2 suppress premature exit from cell division at the Arabidopsis root meristem.
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.
Schwartz et al., Cambridge, United States. In Cell, 2012
Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex).
The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.
Noegel et al., Köln, Germany. In Nucleus, 2012
functions for Nesprin-2 at the nuclear envelope (NE) in gene regulation and in regulation of the actin cytoskeleton which impact on wound healing
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
Shanahan et al., London, United Kingdom. In Plos One, 2011
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
The LINC complex and human disease.
Wehnert et al., Greifswald, Germany. In Biochem Soc Trans, 2011
The LINC components emerin, lamin A/C, SUN1, SUN2, nesprin-1 and nesprin-2 interact with each other at the NE and also with other binding partners including actin filaments and B-type lamins.
Nesprin-2 epsilon: a novel nesprin isoform expressed in human ovary and Ntera-2 cells.
Morris et al., Oswestry, United Kingdom. In Biochem Biophys Res Commun, 2011
novel isoform, nesprin-2-epsilon, was found to be the major mRNA and protein product of the nesprin-2 gene.
Emery-Dreifuss muscular dystrophy.
McNally et al., Chicago, United States. In Handb Clin Neurol, 2010
Additional genes encoding nuclear membrane proteins such as SYNE1 and SYNE2 have also been implicated in EDMD, and in some cases their importance for cardiac and muscle function has been supported by animal modeling.
Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function?
Shanahan et al., Cambridge, United Kingdom. In Expert Rev Mol Med, 2005
Through alternative transcriptional initiation, termination and splicing, two genes - nesprin-1 and nesprin-2 (also known as syne-1 and syne-2) - give rise to many protein isoforms that vary markedly in size.
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