SIRPα interacts with nephrin at the podocyte slit diaphragm.
Tokyo, Japan. In Febs J, 2012
In the glomeruli of CNS patients carrying mutations in NPHS1, where SD formation is disrupted, the expression of SIRPalpha as well as Neph1 and nephrin was significantly decreased, indicating that SIRPalpha is closely associated with the nephrin complex
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm.
Cambridge, United Kingdom. In Nature, 2009
Furthermore, we find that the nephrocyte diaphragm is completely lost in flies lacking the orthologues of nephrin or NEPH1-a phenotype resembling loss of the slit diaphragm in the absence of either nephrin (as in human congenital nephrotic syndrome of the Finnish type, NPHS1) or NEPH1.