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Nasal embryonic LHRH factor

NELF, nasal embryonic LHRH factor
The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, Histone, Gonadotropin-Releasing Hormone, Spt5
Papers on NELF
Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.
Simons et al., Bethesda, United States. In J Biol Chem, Feb 2016
A competition assay, based on a validated chemical kinetic model of steroid hormone action, is now used to identify two new factors (BRD4 and negative elongation factor (NELF)-E) and to define their sites and mechanisms of action.
NF-κB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'→3' exoribonuclease 2 and negative elongation factor.
Nourbakhsh et al., Hannover, Germany. In Faseb J, Jan 2016
In copurification studies, aa 421-429 is required for interactions between NKRF, 5'→3' exoribonuclease 2 (XRN2) and the negative elongation factor (NELF)-E in HeLa cells.
Striatal NELF-mediated RNA polymerase II stalling controls l-dopa induced dyskinesia.
Bézard et al., Bordeaux, France. In Neurobiol Dis, Jan 2016
Their rapid transcription involves the stalling of RNA polymerase II on IEG promoters, a mechanism that critically depends on the presence of the negative elongation factor (NELF) protein complex.
RNAP II processivity is a limiting step for HIV-1 transcription independent of orientation to and activity of endogenous neighboring promoters.
Henderson et al., Boston, United States. In Virology, Dec 2015
We also demonstrate that releasing paused RNAP II by diminishing negative elongation factor (NELF) is sufficient to reactivate transcriptionally repressed HIV-1 provirus regardless of the integration site and orientation of the provirus suggesting that NELF-mediated RNAP II pausing is a common mechanism of maintaining HIV-1 latency.
Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery.
Kim et al., New Haven, United States. In Cell Rep, Dec 2015
HDACIs promote the association of RNA polymerase II (RNAP2) and negative elongation factor (NELF), a complex stabilized by HSP90, at the same genomic sites.
CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.
Murphy et al., Yokohama, Japan. In Transcription, Nov 2015
CTCF knockdown also causes a termination defect on the U2 snRNA genes (U2), by affecting recruitment of negative elongation factor (NELF).
Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profiling.
Lis et al., Ithaca, United States. In Nat Methods, 2014
Using HiTS-RAP, we measured the affinity of mutagenized libraries of GFP-binding and NELF-E-binding aptamers to their respective targets and identified critical regions of interaction.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1, FLRT3, SPRY4, DUSP6, SEMA3A, NELF, and WDR11 genes that are related to defects in neuronal migration.
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond.
Handa et al., Yokohama, Japan. In Biochim Biophys Acta, 2013
DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) were originally identified as factors responsible for transcriptional inhibition by 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole (DRB) and were later found to control transcription elongation, together with P-TEFb, at the promoter-proximal region.
Control of transcriptional elongation.
Lis et al., Ithaca, United States. In Annu Rev Genet, 2012
Among the factors we describe are the pausing factors--NELF (negative elongation factor) and DSIF (DRB sensitivity-inducing factor)--and P-TEFb (positive elongation factor b), which is the key player in pause release.
Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli.
Paro et al., Basel, Switzerland. In Cell, 2012
Using computational and biochemical analyses, we find that Hsp90 maintains and optimizes RNA polymerase II pausing via stabilization of the negative elongation factor complex (NELF).
Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome.
Layman et al., Augusta, United States. In Fertil Steril, 2011
NELF is associated with normosmic idiopathic hypogonadotropic hypogonadism and Kallmann syndrome, either singly or in combination with a mutation in another gene.
Promoter-proximal pausing and its release: molecular mechanisms and physiological functions.
Handa et al., Yokohama, Japan. In Exp Cell Res, 2010
In this review, we discuss biochemical and physiological aspects of elongation control, particularly focusing on the role of the negative elongation factor NELF.
NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration.
Layman et al., Augusta, United States. In Mol Cell Endocrinol, 2010
our findings implicate NELF as a nuclear protein involved in the developmental function of the reproductive axis.
NELF potentiates gene transcription in the Drosophila embryo.
Gergen et al., Stony Brook, United States. In Plos One, 2009
The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A as well as in embryos with reduced levels of maternal NELF-E show that these phenotypes result from the reduced activity of the NELF complex.
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.
Johnsen et al., Göttingen, Germany. In Cell Cycle, 2009
This function appears to be dependent upon not only the phosphorylation of the RNA Polymerase II C-terminal domain but also upon other CDK9 targets such as the Suppressor of Ty Homolog-5 (SUPT5H), Negative Elongation Factor-E (NELF-E) and probably the human Rad6 homolog UBE2A.
Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis.
Kreutz et al., Hamburg, Germany. In J Biol Chem, 2009
Calpain-mediated clipping of the myristoylated N terminus of Jacob is required for its nuclear translocation after N-methyl-d-aspartate receptor activation
Nasal embryonic LHRH factor plays a role in the developmental migration and projection of gonadotropin-releasing hormone 3 neurons in zebrafish.
Gothilf et al., Tel Aviv-Yafo, Israel. In Dev Dyn, 2009
These results suggest that Nelf is an important factor in the developmental migration and projection of GnRH3 neurons in zebrafish.
MicroRNA-133 controls cardiac hypertrophy.
Condorelli et al., Roma, Italy. In Nat Med, 2007
We identified specific targets of miR-133: RhoA, a GDP-GTP exchange protein regulating cardiac hypertrophy; Cdc42, a signal transduction kinase implicated in hypertrophy; and Nelf-A/WHSC2, a nuclear factor involved in cardiogenesis.
Stimulation of RNA polymerase II elongation by hepatitis delta antigen.
Handa et al., Yokohama, Japan. In Science, 2001
Transcription elongation by RNA polymerase II (RNAPII) is negatively regulated by the human factors DRB-sensitivity inducing factor (DSIF) and negative elongation factor (NELF).
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