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Nei endonuclease VIII-like 3

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: NEIL1, NEIL2, NEI, OGG1, NTH1
Papers using NEIL3 antibodies
Forebrain-specific promoter/enhancer D6 derived from the mouse Dach1 gene controls expression in neural stem cells
Luna Luisa et al., In BMC Neuroscience, 2001
... NEIL3 mRNA expression in normal and tumor tissues, we used a Disease Tissue qPCR array (CSRT303; OriGene Technologies) ...
Papers on NEIL3
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Hazra et al., Berkeley, United States. In J Biol Chem, Nov 2015
As in mice deficient in each of the other four oxidized base-specific DGs (OGG1, NTH1, NEIL1, and NEIL3), Neil2-null mice show no overt phenotype.
A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?
Burrows et al., Salt Lake City, United States. In Acs Cent Sci, Sep 2015
These new "spare tire"-containing strands with Gh in loops are now found to be substrates for initiation of BER with the NEIL1, NEIL2, and NEIL3 DNA glycosylases.
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures.
Wallace et al., Burlington, United States. In Nucleic Acids Res, May 2015
Also, the NEIL1 and NEIL3 DNA glycosylases can remove hydantoin lesions but none of the glycosylases, including OGG1, are able to remove 8-oxoG from telomeric quadruplexes.
Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study.
Åsvold et al., Oslo, Norway. In Dna Repair (amst), Apr 2015
METHODS: We evaluated the association of Single Nucleotide Polymorphisms (SNPs) in genes encoding four different BER proteins (NEIL3, OGG1, APEX1 and XRCC1) with the incidence of myocardial infarction in a nested case-control study among participants of the second survey of the HUNT Study.
Increased expression of inflammatory genes in the neonatal mouse brain after hyperoxic reoxygenation.
Saugstad et al., Oslo, Norway. In Pediatr Res, Feb 2015
The inflammatory genes Cxcl10 and Il1b, and the DNA repair gene Neil3, had a higher gene expression change after hyperoxic reoxygenation at one time point only.
DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes.
Nilsson et al., Örebro, Sweden. In Epigenomics, 2014
RESULTS: We found significantly aberrant methylation in 23 genes (NEIL1, NEIL3, DCLRE1C, NHEJ1, GTF2H5, CCNH, CTNNB1, DKK2, DKK3, FZD5 LRP5, TLE3, WNT2, WNT3A, WNT6, TCF7L1, CASP8, EDNRB1, GPC6, KIAA1804, MYO1B, SMAD2 and TTN).
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.
Bjørås et al., Oslo, Norway. In Dna Repair (amst), 2013
In this work, we have purified the glycosylase domain (GD) of human DNA glycosylase NEIL3.
DNA glycosylases search for and remove oxidized DNA bases.
Wallace, Burlington, United States. In Environ Mol Mutagen, 2013
Unlike the other Fpg/Nei family members, Neil3 lacks two of the three void-filling residues that stabilize the DNA duplex and interact with the opposite strand to the damage which may account for its preference for lesions in single-stranded DNA.
Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases.
Doublié et al., Burlington, United States. In Dna Repair (amst), 2013
Here we present the first crystal structure of a viral ortholog of the human NEIL2/NEIL3 proteins, Mimivirus Nei2 (MvNei2), determined at 2.04Å resolution.
Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population.
Li et al., Xianyang, China. In Med Oncol, 2013
After stratification by gender, we found that rs12645561 in NEIL3 and rs2291427 in ALOX5 were associated with developing GBM.
Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context.
Wallace et al., Burlington, United States. In J Biol Chem, 2013
These data suggest that one role for Neil3 and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA.
Genome-wide association study of serum selenium concentrations.
Peters et al., Seattle, United States. In Nutrients, 2013
Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11)
Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.
Wallace et al., Burlington, United States. In Mutat Res, 2013
Endonuclease VIII like proteins (Neil1, Neil2 and Neil3) are found in vertebrate genomes and are homologous to the well-characterized bacterial DNA glycosylases, Formamidopyrimidine DNA glycosylase (Fpg) and Endonuclease VIII (Nei).
Differential expression of DNA repair genes in Hispanic women with breast cancer.
Suarez et al., Ponce, Puerto Rico. In Mol Cancer Biol, 2013
Those candidate genes were CHEK2, EME1 (MMS4L), ERCC3 (XPB), FANCM, H2AFX (H2AX), HMGB1, HUS1, MBD4, NEIL3, PCNA, RAD1, RAD23B, RAD51, RAD54B, RDM1 (RAD52B), SHFM1 (DSS1), TP1, UBE2N (UBC13) and XRCC5 (Ku80).
Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway.
Bjørås et al., Oslo, Norway. In Dna Repair (amst), 2012
both the transcription and protein levels of hNEIL3 fluctuated during the cell cycle
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
Bjørås et al., Oslo, Norway. In Proc Natl Acad Sci U S A, 2011
Neil3 exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells
Eukaryotic endonuclease VIII-like proteins: new components of the base excision DNA repair system.
Zharkov et al., Novosibirsk, Russia. In Biochemistry (mosc), 2011
In 2002, three new human DNA glycosylases (NEIL1, NEIL2, and NEIL3) were discovered, all homologous to endonuclease VIII, a bacterial protein, which also participates in DNA repair.
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.
Wallace et al., Burlington, United States. In Proc Natl Acad Sci U S A, 2010
Neil3 plays a role in repairing 2,6-diamino-4-hydroxy-5-formamidopyrimidine in vivo.
Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.
Zhang et al., Sendai, Japan. In Genes Cells, 2009
NEIL3 partially rescues an E. coli nth nei mutant from hydrogen peroxide sensitivity. Taken together, repair of certain base damage including base loss in ssDNA may be mediated by NEIL3.
Expression patterns of Neil3 during embryonic brain development and neoplasia.
Luna et al., Oslo, Norway. In Bmc Neurosci, 2008
NEIL3 is specifically expressed in brain areas where neurogenesis takes place during development and that its expression is tightly regulated both temporally and spatially. NEIL3 seems to be upregulated in tumor tissues compared to normal tissues.
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