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Pro-melanin-concentrating hormone

The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary by Nahon et al., 1992 [PubMed 1572663]).[supplied by OMIM, Jan 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, NEIL1, ACID, POLYMERASE
Papers on NEI
Functional single nucleotide polymorphism in IL-17A 3' untranslated region is targeted by miR-4480 in vitro and may be associated with age-related macular degeneration.
Tuo et al., Bethesda, United States. In Environ Mol Mutagen, Jan 2016
The SNP rs7747909 was found to be associated with AMD (P < 0.05) in the NEI cohort, using a dominant model logistic regression.
Inter-relationships among alternative definitions of feed efficiency in grazing lactating dairy cows.
Berry et al., Cork, Ireland. In J Dairy Sci, Jan 2016
Net energy intake (NEI) from pasture and concentrate intake was estimated up to 8 times per lactation for 2,693 lactations from 1,412 Holstein-Friesian cows.
First detection of severe fever with thrombocytopenia syndrome virus in the tick species Haemaphysalis concinna in Shandong Province, China.
Chai et al., Tai'an, China. In Parasitol Res, Dec 2015
With regard to the phylogenetic analysis, the Nei-Gojobri (Kimura 2-parameter) method was used to construct the phylogenetic trees.
[Alternative Ways of Pinus sylvestris L. Migration from Southern Siberia to Europe and Asia Minor].
Egorov et al., In Izv Akad Nauk Ser Biol, Sep 2015
Allozyme analysis of the parameters of the Nei genetic distances and gene flow between the populations of Scots pine Pinus sylvestris L. along two hypothetical alternative ways of their migrations in the Miocene-Pliocene from Southern Siberia to the Balkans, Central Europe, and Asia Minor was used; a lower probability of their settlement on the southern shores of the East Paratethys than on the northern ones was identified.
New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.
Hegde et al., Houston, United States. In Cell Mol Life Sci, May 2015
Following up our earlier studies, which showed that the Nei endonuclease VIII like 1 (NEIL1) DNA glycosylase, one of the five base excision repair (BER)-initiating enzymes in mammalian cells, has enhanced expression during the S-phase and higher affinity for replication fork-mimicking single-stranded (ss) DNA substrates, we recently provided direct experimental evidence for NEIL1's role in replicating template strand repair.
The comprehensive immunomodulation of NeurimmiRs in haemocytes of oyster Crassostrea gigas after acetylcholine and norepinephrine stimulation.
Song et al., Qingdao, China. In Bmc Genomics, 2014
BACKGROUND: Neural-endocrine-immune (NEI) system is a major modulation network among the nervous, endocrine and immune system and weights greatly in maintaining homeostasis of organisms during stress and infection.
Sexual Dimorphisms of Adrenal Steroids, Sex Hormones, and Immunological Biomarkers and Possible Risk Factors for Developing Rheumatoid Arthritis.
Aldag et al., Peoria, United States. In Int J Endocrinol, 2014
Less data have been available on altered interrelations of the combined neuroendocrine and immune (NEI) systems as risk factors for development of certain diseases.
Population genetic study of 34 X-Chromosome markers in 5 main ethnic groups of China.
Li et al., Shanghai, China. In Sci Rep, 2014
Highest values of Nei genetic distance were always observed at HUI-Uygur pairwise when analyzed with X-STRs or X-Indels separately and combined.
Effect of Endometrial Injury on Secretion of Endometrial Cytokines and IVF Outcomes in Women with Unexplained Subfertility.
Wang et al., Beijing, China. In Mediators Inflamm, 2014
38 patients in the EI group underwent EI in the mid-luteal phase of the cycle and 28 patients in the non-EI (NEI) group.
Genetic diversity analysis of Capparis spinosa L. populations by using ISSR markers.
Yang et al., China. In Genet Mol Res, 2014
The Nei gene of C. spinosa populations in different regions had Diversity and Shannon's information index ranges of 0.1312-0.2001
Acupuncture modulates the neuro-endocrine-immune network.
Xu et al., Tianjin, China. In Qjm, 2014
As a nonspecific physical stimulation, the effect of acupuncture on diseases is produced by motivating the inherent regulatory system in the body, having the characteristics of whole regulation, dual directional regulation, etc. Modern scientific researches show that body's inherent regulatory system is neuro-endocrine-immune (NEI) network.
Nucleo-cytoplasmic transport as a therapeutic target of cancer.
Festuccia et al., In J Hematol Oncol, 2013
KPT-330 is the only NEI currently in Phase I/II human clinical trials in hematological and solid cancers.
DNA glycosylases search for and remove oxidized DNA bases.
Wallace, Burlington, United States. In Environ Mol Mutagen, 2013
This review article presents, an overview of the DNA glycosylases that recognize oxidized DNA bases using the Fpg/Nei family of DNA glycosylases as models for how structure can inform function.
Interleukin-6 receptor α is co-localised with melanin-concentrating hormone in human and mouse hypothalamus.
Jansson et al., Göteborg, Sweden. In J Neuroendocrinol, 2012
Melanin-concentrating hormone (MCH) neurons of human hypothalamus, as well as the MCH neurons of mouse hypothalamus, contain IL-6Ralpha.
Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.
Palmiter et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2012
AgRP-expressing neurons play a critical role in mediating the metabolic syndrome and infertility of Lep(ob/ob) mice, whereas MCH-expressing neurons have only a minor role
Expression levels of genes encoding melanin concentrating hormone (MCH) and MCH receptor change in taste aversion, but MCH injections do not alleviate aversive responses.
Schiöth et al., Saint Paul, United States. In Pharmacol Biochem Behav, 2012
Data suggest that MCH and its receptor (MCHR1) form an orexigenic system whose expression is affected in conditioned taste aversion. MCH expression is up-regulated in hypothalamus (and possibly amygdala) of aversive animals.
Management of postoperative nausea and vomiting in women scheduled for breast cancer surgery.
Fujii, Tokyo, Japan. In J Anesth, 2011
Fourth, electro-acupoint stimulation at the P6 point (Nei-Guwan) as a non-pharmacologic therapy is as effective as ondansetron for preventing PONV.
Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration.
Maratos-Flier et al., Boston, United States. In Behav Brain Res, 2011
The hypothalamic inputs through MCH play an important role in regulating sensory integration from olfactory pathways.
Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats.
Celis et al., Córdoba, Argentina. In Peptides, 2011
Hypo- and hyperthyroidism affect neuropeptide EI (NEI) concentration in discrete brain areas of adult male rats.
A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition.
Dietz et al., Baltimore, United States. In Nat Biotechnol, 2001
Transcripts are ranked by a nonsense enrichment index (NEI), which relates expression changes for a given transcript in NMD-inhibited control and patient cell lines.
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