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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Neural precursor cell expressed, developmentally down-regulated 4

Nedd4, Nedd4-1
may regulate function of the amiloride-sensitive epithelial sodium channel ENaC [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Ubiquitin, Rsp5, V1a, CAN, PTEN
Papers using Nedd4 antibodies
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.
Uversky Vladimir N., In PLoS ONE, 2004
... used during immunofluorescence include: mouse polyclonal anti-LITAF antibody (dilution 1/100, BD Biosciences, San Jose, CA); anti-Nedd4 antibodies (dilution 1/100, BD Biosciences, Mississauga, ON); α-tubulin antibody ...
Papers on Nedd4
NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.
Liao et al., Memphis, United States. In Hum Mol Genet, Feb 2016
We demonstrate that elevated NEDD4 is implicated as the responsible ubiquitin E3 ligase for HSF1 degradation through UPS.
Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.
Ahnfelt-Rønne et al., Denmark. In Mol Endocrinol, Jan 2016
These included several proteins, not previously associated with pregnancy-induced islet expansion, such as CLIC1, STMN1, MCM6, PPIB, NEDD4, and HLTF.
The Nedd4-1 WW domain recognizes the PY motif peptide through a coupled folding-binding equilibrium.
Dingley et al., In Biochemistry, Jan 2016
UNASSIGNED: The four WW domains of human Nedd4-1 (Neuronal precursor cell expressed developmentally down-regulated gene 4-1) interact with the poly-proline (PY) motifs of the human epithelial Na+ channel (hENaC) subunits, with the third WW domain (WW3*) showing the highest affinity.
Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.
Bienz et al., Cambridge, United Kingdom. In Open Biol, Dec 2015
Its levels are controlled by ubiquitylation, mediated by various ubiquitin ligases, including NEDD4 family members that bind to a conserved PPxY motif in Dishevelled (mammalian Dvl1-3).
PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle.
Batt et al., Toronto, Canada. In Biochem J, Dec 2015
The ubiquitin proteasome system (UPS) is the predominant proteolytic machinery responsible for atrophy of skeletal muscle and Nedd4-1 is one of a series of E3 ubiquitin ligases identified to mediate inactivity-induced muscle wasting.
Molecular functions of NEDD4 E3 ubiquitin ligases in cancer.
Blank et al., Ẕefat, Israel. In Biochim Biophys Acta, Aug 2015
In this review, we summarize and discuss recent discoveries on the roles of NEDD4 E3s in cancer.
NEDD4-2 and salt-sensitive hypertension.
Staub et al., Lausanne, Switzerland. In Curr Opin Nephrol Hypertens, Mar 2015
SUMMARY: The emerging role of NEDD4-2 in the regulation of different Na+ transporters along the nephron and the identification of human polymorphisms in the NEDD4-2 gene (Nedd4L) related to salt-sensitive hypertension makes this ubiquitin-protein ligase an interesting target for the development of antihypertensive drugs.
NEDD4: The founding member of a family of ubiquitin-protein ligases.
Kumar et al., Adelaide, Australia. In Gene, Mar 2015
The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes.
NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins.
Kumar et al., Adelaide, Australia. In Gene, Mar 2015
NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover.
NEDD4-1 and PTEN expression in keloid scarring.
Zhu et al., Hefei, China. In Genet Mol Res, 2014
The aim of this study was to determine the expression of the PTEN tumor suppressor and NEDD4-1 genes in keloid tissue and explore their effect on the formation of such scarring.
Regulation of ERBB3/HER3 signaling in cancer.
An et al., Houston, United States. In Oncotarget, 2014
These proteins include PI3K, Shc, and E3 ubiquitin ligases NEDD4 and Nrdp1.
Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration.
Liao et al., Memphis, United States. In J Neurosci, 2012
This study demonistrated that the first time that zinc can induce IGF-1Rbeta protein degradation in neurons via NEDD4-mediated ubiquitination and the subsequent UPS mechanism.
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.
Goldberg et al., Boston, United States. In Proc Natl Acad Sci U S A, 2011
ubiquitination by Nedd4 targets alpha-synuclein to the endosomal-lysosomal pathway and, by reducing alpha-synuclein content, may help protect against the pathogenesis of Parkinson disease and other alpha-synucleinopathies
WWP2 is an E3 ubiquitin ligase for PTEN.
Chen et al., Hyderābād, India. In Nat Cell Biol, 2011
WWP2 is an E3 ubiquitin ligase that belongs to the NEDD4-like protein family, which is involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes.
Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.
Nakamura et al., Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2010
NEDD4 upregulated expressions of fibronectin and type 1 collagen and contributed to the excessive accumulation of extracellular matrix.
A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.
Rotin et al., Toronto, Canada. In Plos One, 2010
Data suggest a role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.
A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila.
Rotin et al., Toronto, Canada. In Plos One, 2010
splice isoforms of the same dNedd4 gene can lead to opposite effects on neuromuscular synaptogenesis
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
Zembutsu et al., Tokyo, Japan. In Nat Genet, 2010
Association of rs8032158 located in NEDD4 on chromosome 15 yielded P = 5.96 x 10(-13) (OR = 1.51).
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Lin et al., Houston, United States. In Cancer Cell, 2009
Knockdown of Rak enhanced the binding of PTEN to its E3 ligase NEDD4-1 and promoted PTEN polyubiquitination, leading to PTEN protein degradation.
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
Jiang et al., New York City, United States. In Cell, 2007
NEDD4-1 is a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53.
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