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Poliovirus receptor-related 4

Nectin-4, PVRL4, PRR4
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: SLAM, CD46, CAN, nectin-1, ACID
Papers on Nectin-4
A Novel Nectin-mediated Cell Adhesion Apparatus Which Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development.
Takai et al., Kōbe, Japan. In J Biol Chem, Feb 2016
This apparatus was formed by the trans-interaction between the cell adhesion molecules nectin-4 and nectin-1, which were expressed in the luminal and basal cells, respectively.
A chicken homologue of nectin-4 functions as a measles virus receptor.
Takeda et al., Tokyo, Japan. In Vaccine, Feb 2016
Measles virus (MV) vaccine strains use CD46, signaling lymphocyte activation molecule, and nectin-4 in human cells as receptors.
Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4).
Grus et al., Mainz, Germany. In Proteomics, Oct 2015
The analysis of the reflex tear proteome demonstrated increased abundance in proline-rich protein 4 (PRR4) and zymogen granule protein 16 homolog B (ZG16B) for the first time.
The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia.
Sinn et al., Iowa City, United States. In J Virol, Jul 2015
UNLABELLED: The discovery that measles virus (MV) uses the adherens junction protein nectin-4 as its epithelial receptor provides a new vantage point from which to characterize its rapid spread in the airway epithelium.
SLAM- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes.
Plattet et al., Bern, Switzerland. In J Virol, May 2015
UNLABELLED: Measles and canine distemper viruses (MeV and CDV, respectively) first replicate in lymphatic and epithelial tissues by using SLAM and nectin-4 as entry receptors, respectively.
Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.
Nakagohri et al., Japan. In Surg Today, Apr 2015
Tumors over 4 cm in diameter had more intense staining for nectin-4 than smaller tumors (p = 0.035).
Pathological consequences of systemic measles virus infection.
Duprex et al., Boston, United States. In J Pathol, 2015
The identification of poliovirus receptor-like 4 (PVRL4) as the second natural receptor for measles virus (MV) has closed a major gap in our understanding of measles pathogenesis, and explains how this predominantly lymphotropic virus breaks through epithelial barriers to transmit to a susceptible host.
Down-regulation of nectin-4 inhibits apoptosis in systemic lupus erythematous (SLE) through targeting Bcl-2/Bax pathway.
Huang et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
PURPOSE: The purpose of this study was to investigate the potential role of nectin-4 in systemic lupus erythematous (SLE) cell apoptosis during the disease development and its potential mechanism.
Gene expression profiling of pre-eclamptic placentae by RNA sequencing.
FINNPEC Core Investigator Group et al., Helsinki, Finland. In Sci Rep, 2014
Some of the genes identified in our study have been reported by numerous microarray studies (BHLHE40, FSTL3, HK2, HTRA4, LEP, PVRL4, SASH1, SIGLEC6), but many have been implicated in only few studies or have not previously been linked to pre-eclampsia (ARMS2, BTNL9, CCSAP, DIO2, FER1L4, HPSE, LOC100129345, LYN, MYO7B, NCMAP, NDRG1, NRIP1, PLIN2, SBSPON, SERPINB9, SH3BP5, TET3, TPBG, ZNF175).
Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM.
Plattet et al., Bern, Switzerland. In J Virol, 2014
UNLABELLED: Measles virus (MeV) and canine distemper virus (CDV) possess tetrameric attachment proteins (H) and trimeric fusion proteins, which cooperate with either SLAM or nectin 4 receptors to trigger membrane fusion for cell entry.
The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses.
Richardson et al., Halifax, Canada. In Viruses, 2014
PVRL4 (nectin-4) was recently identified as the epithelial receptor for members of the Morbillivirus genus, including measles virus, canine distemper virus and peste des petits ruminants virus.
Structural basis of efficient contagion: measles variations on a theme by parainfluenza viruses.
Cattaneo et al., Rochester, United States. In Curr Opin Virol, 2014
While many of these viruses bind sialic acid to enter cells, wild type measles binds exclusively two tissue-specific proteins, the lymphatic receptor signaling lymphocytic activation molecule (SLAM), and the epithelial receptor nectin-4.
Using the ferret model to study morbillivirus entry, spread, transmission and cross-species infection.
Duprex et al., Boston, United States. In Curr Opin Virol, 2014
Combining fluorescent protein expressing recombinant viruses and multimodal, macroscopic and microscopic imaging modalities has highlighted the differential role of the cellular receptors CD150 and PVRL4 in disease progression.
Purification, crystallization and preliminary X-ray analysis of the IgV domain of human nectin-4.
Cai et al., China. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystals of nectin-4 diffracted to 1.8 A resolution and belonged to space group P2(1), with unit-cell parameters a = 33.1, b = 51.7, c = 56.9 A, beta = 94.7 degrees
Adherens junction protein nectin-4 is the epithelial receptor for measles virus.
Cattaneo et al., Langen, Germany. In Nature, 2012
measles virus targets nectin-4 to emerge in the airways
Takeda et al., In Uirusu, 2011
Recently, a new cell receptor for measles virus, nectin4 was identified.
Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus.
Richardson et al., Halifax, Canada. In Plos Pathog, 2011
Measles virus infection reduced PVRL4 surface expression in MCF7 cells, a property that is characteristic of receptor-associated viral infections.
Mutation in PVRL4 gene encoding nectin-4 underlies ectodermal-dysplasia-syndactyly syndrome (EDSS1).
Ahmad et al., Islamabad, Pakistan. In J Hum Genet, 2011
Sequence analysis revealed a homozygous missense mutation (c.635C>G; p.Pro212Arg) in the recently reported PVRL4 gene causing EDSS1
The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma.
Athanassiadou et al., Athens, Greece. In Folia Histochem Cytobiol, 2010
The findings of study suggest that increased expression of Nectin-4 may indicate a worse prognosis in breast cancer patients.
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