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Poliovirus receptor-related 1

nectin-1, HveC, PRR1, PVRL1
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD45, HVEM, CAN, HAD, V1a
Papers using nectin-1 antibodies
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
Miyoshi Jun et al., In Journal of Cell Science, 1998
... of the following antibodies were purchased from commercial sources: antibodies against afadin and nectin-3 (ABcam), nectin-1 (Santa Cruz Biotechnology), nectin-2 (Hycult), E-cadherin (R&D ...
Papers on nectin-1
A Novel Nectin-mediated Cell Adhesion Apparatus Which Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development.
Takai et al., Kōbe, Japan. In J Biol Chem, Feb 2016
This apparatus was formed by the trans-interaction between the cell adhesion molecules nectin-4 and nectin-1, which were expressed in the luminal and basal cells, respectively.
A G-Box-Like Motif Is Necessary for Transcriptional Regulation by Circadian Pseudo-Response Regulators in Arabidopsis.
Farré et al., East Lansing, United States. In Plant Physiol, Jan 2016
Here, we identified genome-wide targets of PRR9 using chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) and compared them with PRR7, PRR5, and TOC1/PRR1 ChIP-seq data.
Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin.
Ivarsson et al., Marseille, France. In Febs Lett, Jan 2016
We validate the interaction with nectin-1 through orthogonal assays.
Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus.
Mori et al., Kōbe, Japan. In Genes Cells, Jan 2016
We previously showed that cell adhesion molecules nectin-1 and nectin-3 are localized at puncta adherentia junctions of the hippocampal mossy fiber glutamatergic excitatory synapses and that they do not regulate the excitatory synaptic transmission onto the CA3 pyramidal cells.
Deletion of a Predicted β-sheet Domain within the Amino-terminus of Herpes Simplex Virus Glycoprotein K (gK) Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons.
Kousoulas et al., Baton Rouge, United States. In J Virol, Jan 2016
In this assay, cell-surface bound virions were detected by the colocalization of glycoprotein D (gD) and its cognate receptor nectin-1 on infected neuronal surfaces.
Structure-function relationships in mammalian histidine-proline-rich glycoprotein.
Raggi et al., Pisa, Italy. In Biochimie, Nov 2015
The multidomain arrangement of HPRG comprises two modules at the N-terminus that are homologous to cystatin but void of cysteine proteinase inhibitor function, and a second half consisting of a histidine-proline-rich region (HPRR) located between two proline-rich regions (PRR1 and PRR2), and a C-terminus domain.
Human Blastocyst Secreted microRNA Regulate Endometrial Epithelial Cell Adhesion.
Dimitriadis et al., Australia. In Ebiomedicine, Oct 2015
miR-661 uptake by HEEC reduced trophoblast cell line spheroid attachment to HEEC via PVRL1.
Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity.
Almo et al., United States. In Cell Mol Life Sci, Feb 2015
The nectins, a family of four immunoglobulin superfamily members (nectin-1 to -4), interact through their extracellular domains to support cell-cell adhesion.
Nectinopathies: an emerging group of ectodermal dysplasia syndromes.
Fortugno et al., Chieti, Italy. In G Ital Dermatol Venereol, 2013
We propose refer to these entities (nectin 1-ED and nectin 4-ED) as "nectinopathies", which are likely to be underestimated/underdiagnosed ED syndomes.
The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.
Hidalgo et al., Barcelona, Spain. In Nucleic Acids Res, 2012
The ability of Pap1 to bind and activate drug tolerance promoters is independent on Prr1, whereas its affinity for the antioxidant promoters is significantly enhanced upon association with Prr1.
αVβ3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts.
Campadelli-Fiume et al., Bologna, Italy. In J Virol, 2012
alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1.
Characterization of nectin processing mediated by presenilin-dependent γ-secretase.
Lim et al., Washington, D.C., United States. In J Neurochem, 2011
Loss of presenilin 1/gamma-secretase activity delays processing of nectin-1 and causes accumulation of its full-length and carboxyl-terminal fragments.
Innate immunity in atopic dermatitis.
Schauber et al., München, Germany. In Clin Rev Allergy Immunol, 2011
Eczema herpeticum is a disseminated viral infection almost exclusively diagnosed in AD patients, which is based on unmasking of the viral entry receptor nectin-1, lack of cathelicidin production by keratinocytes, and depletion of Type I IFN-producing plasmacytoid dendritic cells from AD skin.
Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.
Carfi et al., Roma, Italy. In Plos Pathog, 2011
Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.
Nectins establish a checkerboard-like cellular pattern in the auditory epithelium.
Takai et al., Kōbe, Japan. In Science, 2011
hair cells and supporting cells express nectin-1 and -3, respectively; their interaction mediates the heterotypic adhesion between these 2 cell types; nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia
Current aspects of innate and adaptive immunity in atopic dermatitis.
Klein et al., München, Germany. In Clin Rev Allergy Immunol, 2007
The desmosomal protein nectin-1 is unmasked in AD lesions, thus becoming a relevant herpes simplex virus (HSV) entry receptor.
Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela.
Spritz et al., Denver, United States. In Nat Genet, 2001
Homozygosity for a nonsense mutation of PVRL1, W185X, results in an autosomal recessive CL/P syndrome on Margarita Island, CLPED1 (ref.
Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia.
Spritz et al., Denver, United States. In Nat Genet, 2000
Here we describe positional cloning of the gene responsible for an autosomal recessive CL/P-ectodermal dysplasia (ED) syndrome (CLPED1; previously ED4; ref. 2), which we identify as PVRL1, encoding nectin-1, an immunoglobulin (Ig)-related transmembrane cell-cell adhesion molecule that is part of the NAP cell adhesion system.
Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.
Spear et al., Chicago, United States. In Science, 1998
This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC.
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