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NudE nuclear distribution gene E homolog 1

NdeI, NDE1, Nde1p
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, ACID, Nudel, HAD
Papers using NdeI antibodies
Measuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domain.
Pizzo Salvatore V., In PLoS ONE, 2010
... The product was purified, digested with Nde1 and Xho1 and cloned into the pET28b(+) (Novagen, Merck KgGA, Darmstadt, Germany) expression ...
Structural Insights of the Nucleotide-Dependent Conformational Changes of Thermotoga maritima MutL Using Small-Angle X-ray Scattering Analysis.
Marinus Martin G., In PLoS ONE, 2008
... The forward and reverse primers incorporated NdeI and SapI restriction sites, respectively, for subcloning into the pTWIN1 vector [23] (New England Biolabs, Inc.) ...
Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databases
Arcus Vickery, In PLoS ONE, 2007
... The insert was next restriction digested from the pGEM-T vector with NdeI and XhoI and cloned into a modified pET-28 plasmid (Merck, Darmstadt, Germany) (with the ...
Molecular regulation of apoptosis in fast plantaris muscles of aged rats.
Blagosklonny Mikhail V., In PLoS ONE, 2005
... construction of the wild-type Id2 plasmids, cDNAs encoding full-length murine Id2 were inserted into the Nde1/HindIII sites of the pDNR-1r vector (BD Biosciences, Palo Alto, CA, USA) ...
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Papers on NdeI
Disruption of PHO13 improves ethanol production via the xylose isomerase pathway.
Kondo et al., Kōbe, Japan. In Amb Express, 31 Dec 2016
Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YΔGP/XK/XI strain.
SfiNX: a method for assembly of protein coding sequences with high success rates.
Hisamatsu et al., Japan. In Biotechnol Lett, Feb 2016
OBJECTIVE: Concatenation of two NdeI-XhoI gene fragments via an oligonucleotide linker on a plasmid vector with an SfiI site was performed to evaluate success rates in construction of polycistronic genes expressible in Escherichia coli.
An interaction between NDE1 and high birth weight increases schizophrenia susceptibility.
Hennah et al., Helsinki, Finland. In Psychiatry Res, Jan 2016
We found a significant interaction between birth weight and two NDE1 markers in relation to increased schizophrenia risk: a four SNP haplotype spanning NDE1 (b=1.26,
Expression and Purification of the Uropathogenic Escherichia coli PapG Protein and its Surface Absorption on Lactobacillus reuteri: Implications for Surface Display System Vaccines.
Aghasadeghi et al., Tehrān, Iran. In Jundishapur J Microbiol, Sep 2015
The PapG.AcmA fusion gene was digested with BamHI and NdeI and sub-cloned into the pET21a expression vector at the digestion sites.
High prevalence of diabetic retinopathy and lack of association with integrin α2 gene polymorphisms in patients with type 2 diabetes from Northeastern Mexico.
Córdova-Alvelais et al., Saltillo, Mexico. In Exp Ther Med, Aug 2015
The gene encoding the α2 subunit of α2β1 integrin has ≥8 polymorphisms, including a BglII/NdeI restriction fragment length polymorphism.
An Association Study on IL16 Gene Polymorphisms with the Risk of Sporadic Alzheimer's Disease.
Khorram Khorshid et al., Tehrān, Iran. In Avicenna J Med Biotechnol, Jul 2015
Genotyping of rs11556218 T/G and rs4778889 T/C polymorphisms was performed by PCR-RFLP method using the NdeI and AhdI restriction enzymes, respectively.
Expression of Recombinant Human Insulin-like Growth Factor Type 1 (rhIGF-1) in Escherichia coli.
Shahbazi et al., Gorgān, Iran. In Avicenna J Med Biotechnol, Jul 2015
Then, the gene was synthesized and inserted in pET-24a vector by a cutting strategy included NdeI and BamHI-HF enzymes.
Current topics of functional links between primary cilia and cell cycle.
Inagaki et al., Nagoya, Japan. In Cilia, 2014
In the elongation step, Nde1, a negative regulator of ciliary length, is revealed to be ubiquitylated and degraded by CDK5-SCF(Fbw7) in a cell cycle-dependent manner.
Isolation, cloning, and expression of E. coli BirA gene for biotinylation applications.
Azadmanesh et al., Tehrān, Iran. In Adv Biomed Res, 2014
BirA amplicon harboring a GS-linker at its C-terminal was cloned into NdeI-XhoI sites of pET24a(+) vector under control of T7 promoter and upstream of the vector-derived 6xHis-tag.
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Hoogenraad et al., Utrecht, Netherlands. In Biochem Soc Trans, 2013
In addition, genetic defects associated with these and other neurological disorders have been found in multifunctional adaptors that regulate dynein function, including the dynactin subunit p150(Glued), BICD2 (Bicaudal D2), Lis-1 (lissencephaly 1) and NDE1 (nuclear distribution protein E).
NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.
Soares et al., Düsseldorf, Germany. In Biomol Concepts, 2013
Nuclear distribution element 1 (NDE1, also known as NudE) and NDE-like 1 (NDEL1, also known as Nudel) are paralogous proteins essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders.
DISC1-binding proteins in neural development, signalling and schizophrenia.
Porteous et al., Edinburgh, United Kingdom. In Neuropharmacology, 2012
APP, Dixdc1, LIS1, NDE1, NDEL1), neural progenitor proliferation (GSK3β), neurosignalling (Girdin, GSK3β, PDE4) and synaptic function (Kal7, TNIK).
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms.
Xu et al., Houston, United States. In Cell Res, 2012
It forms homo- or hetero-dimers in order to bind the Nde1 E-box element and activate or repress its target genes.
Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.
Vallee et al., New York City, United States. In J Biol Chem, 2011
Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.
Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes.
Feng et al., Chicago, United States. In Plos Biol, 2011
A three-dimensional regulation of radial glial cells' cytoarchitecture by the Lis1-Nde1-DGC complex determines the number and spatial organization of cortical neurons as well as the size and shape of the cerebral cortex.
Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected].
Walsh et al., Riyadh, Saudi Arabia. In Am J Hum Genet, 2011
NDE1 mutations cause a severe microlissencephaly syndrome. Patient's NDE1 proteins are unstable, cannot bind cytoplasmic dynein, and do not localize properly to the centrosome.
The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.
Woods et al., New Haven, United States. In Am J Hum Genet, 2011
NDE1 deficiency causes both a severe failure of neurogenesis and a deficiency in cortical lamination
Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry.
Tsiokas et al., Oklahoma City, United States. In Nat Cell Biol, 2011
These data suggest that Nde1 is an integral component of a network coordinating ciliary length with cell cycle progression.
Do cilia put brakes on the cell cycle?
Jackson, In Nat Cell Biol, 2011
Nde1, a known partner of dynein light chain LC8, controls ciliary length in vitro and in zebrafish, and influences the G1-S progression.
More papers using NdeI antibodies
Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2
Chilukuri Nageswararao et al., In Journal of Burns and Wounds, 2003
... Quick Ligation Kit and restriction endonucleases, Nde1 and BamH1, were purchased from New England Biolabs (Beverly, MA) ...
Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2
Chilukuri Nageswararao et al., In Eplasty, 2003
... Quick Ligation Kit and restriction endonucleases, Nde1 and BamH1, were purchased from New England Biolabs (Beverly, MA) ...
STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins.
Gerrard Juliet Ann, In PLoS ONE, 2003
... NdeI and XhoI (New England BioLabs) were used to transfer ...
Translokation und Maturierung von Cytochromen c.
Driscoll Paul C., In PLoS ONE, 2000
... Subsequently, the mutant GFP gene was amplified by pcr and cloned into the NdeI/BamHI restriction sites of pET3a (New England Biolabs), resulting in pGFP4 ...
In vivo visualization of type II plasmid segregation: bacterial actin filaments pushing plasmids
Mullins R. Dyche et al., In The Journal of Cell Biology, 1996
... make a GFP fusion to the ParM gene from plasmid R1-19 and was inserted into the NDE1 and BamH1 sites of pET11a (New England Biolabs, Inc.) to create pCC110 ...
Attachment of drugs to polyethylene glycols
Silvius John R. et al., In The Journal of Cell Biology, 1982
... expressed from a plasmid constructed by inserting the complete coding sequence of the protein between the NdeI and BamHI sites of pMAL-p4X (New England Biolabs, Inc.), was purified from ...
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