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ND4 NADH dehydrogenase, subunit 4 (complex I)

ND4, NADH dehydrogenase subunit 4
Top mentioned proteins: ND5, DiI, ND6, HAD, CAN
Papers on ND4
Evolution around the Red Sea: Systematics and biogeography of the agamid genus Pseudotrapelus (Squamata: Agamidae) from North Africa and Arabia.
Carranza et al., Tel Aviv-Yafo, Israel. In Mol Phylogenet Evol, Feb 2016
We included all known species and subspecies, and sequenced them for mitochondrial (16S, ND4 and tRNAs) and nuclear (MC1R, c-mos) markers.
Determining geographical variations in Ascaris suum isolated from different regions in northwest China through sequences of three mitochondrial genes.
Lin et al., China. In Mitochondrial Dna, Feb 2016
UNASSIGNED: The sequence diversities in three mitochondrial DNA (mtDNA) regions, namely portions of NADH dehydrogenase subunit 1 (pnad1), cytochrome c oxidase subunit 1 (pcox1), and NADH dehydrogenase subunit 4 (pnad4), were investigated in all Ascaris suum samples isolated from four regions in northwestern China.
Complete mitochondrial genome of Tlacuatzin canescens (Grayish Mouse Opossum).
Pang, Qingdao, China. In Mitochondrial Dna, Jan 2016
ND4 gene and ND4L gene were overlapped by 4 bp, and ATP8 gene and ATP6 gene were overlapped by 45 bp.
Complete mitochondrial genome of Aulonocara stuartgranti (Flavescent peacock cichlid).
Gao et al., Shenzhen, China. In Mitochondrial Dna, Jan 2016
ATP8 and ATP6 genes overlap by nine nucleotides, ND5 and ND6 genes by four nucleotides, and ND4L and ND4 genes share six nucleotides.
The complete mitochondrial genome of Acanthosaura lepidogaster (Squamata: Agamidae).
Lin et al., Hangzhou, China. In Mitochondrial Dna, Jan 2016
We constructed a phylogeny that included for 10 species of Leiolepidinae lizards and one outgroup Leiocephalus personatus constructed in BEAST, based on 15 mitochondrial genes (12S, 16S, ND1, ND2, COI, COII, ATP8, ATP6, COIII, ND3, ND4L, ND4, ND5, ND6, and cytochrome b).
The complete mitochondrial genome of Hequ Tibetan Mastiff Canis lupus familiaris (Carnivora: Canidae).
Lu et al., Lanzhou, China. In Mitochondrial Dna, Jan 2016
AGA for CYTB, TAA for ATP6, ATP8, COX1, COX2, ND1, ND4L, ND5 and ND6, and an incomplete stop codon T for COX3, ND2, ND3 and ND4.
The complete mitochondrial genome of the fulvous parrotbill Paradoxornis fulvifrons (Passeriformes: Muscicapidae).
Dai et al., Leshan, China. In Mitochondrial Dna, Jan 2016
One PCG (COX1) is terminated with AGG, three PCGs (COX3, ND2 and ND4) with the incomplete stop codon T--/TA-, while all the others with TAA.
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries.
Zhao et al., Nanjing, China. In Sci Rep, Dec 2015
Moreover, mtDNA sequences coding for 12S, 16S rRNA and ND4, as well as the D-loop region were significantly hypermethylated in PCO oocytes.
How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models.
Lambin et al., Maastricht, Netherlands. In Mutat Res Rev Mutat Res, Apr 2015
Mutations in MT-ND4 and mtDNA depletion have been reported to be involved in cisplatin resistance.
Medical management of hereditary optic neuropathies.
Carelli et al., Bologna, Italy. In Front Neurol, 2013
The diagnostic workup includes neuro-ophthalmologic evaluation and genetic testing of the three most common mitochondrial DNA mutations affecting complex I (11778/ND4, 3460/ND1, and 14484/ND6) for LHON and sequencing of the nuclear gene OPA1 for DOA.
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.
Guy et al., Miami, United States. In Proc Natl Acad Sci U S A, 2012
Expression of WT human ND4 in cells with the G11778A mutation in ND4 led to restoration of defective ATP synthesis.
Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.
Pravenec et al., Praha, Czech Republic. In Physiol Genomics, 2012
Inherited variation mt-Nd2, mt-Nd4, and mt-Nd5 can influence glucose and lipid metabolism when expressed on the nuclear genetic background of the SHR strain.
Is Leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case.
Sadun et al., Los Angeles, United States. In J Neuroophthalmol, 2012
Two months later, the diagnosis of Leber hereditary optic neuropathy (LHON) 11778/ND4 was established and the patient was treated with 900 mg of idebenone daily.
Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia.
Morgan et al., Hannover, Germany. In Leukemia, 2012
Patients with somatically acquired ND4 mutations had significantly longer relapse-free survival (P=0.017) and overall survival (OS) (P=0.021) than ND4(wildtype) patients
Mutations in mitochondrially encoded complex I enzyme as the second common cause in a cohort of Chinese patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes.
Wang et al., Beijing, China. In J Hum Genet, 2011
Our data emphasize the important role of MTND mutations in the pathogenicity of MELAS, especially MELAS/LS overlap syndrome.
Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in senescence-accelerated mouse strain, SAMP8.
Hayashi et al., Tsukuba, Japan. In Exp Anim, 2010
Cybrid mice showed normal respiratory function whether or not their mtDNA possessed the A11181G mutation of the mt-Nd4 gene, suggesting that the this mutation is not responsible for respiration defects found in SAMP8 mice.
[The influence of mitochondrial haplogroup on Leber's hereditary optic neuropathy].
Guan et al., Wenzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2008
The ND1 G3460A, ND4 G11778A and ND6 T14484C mutations in the genes encoding the subunits of respiratory chain complex I, account for more than 50% of LHON families worldwide.
Mitochondrial DNA-Associated Leigh Syndrome and NARP
Rahman et al., Seattle, United States. In Unknown Journal, 2003
MT-ATP6, MT-TL1, MT-TK, MT-TW, MT-TV, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND5, MT-ND6, and MT-CO3 are the mitochondrial genes in which pathogenic variants are known to cause mtDNA-associated Leigh syndrome.
A mitochondrial DNA mutation as a cause of Leber's hereditary optic neuropathy.
Wallace et al., Atlanta, United States. In N Engl J Med, 1989
This mutation converts the 340th amino acid of NADH dehydrogenase subunit 4 from an arginine to a histidine and eliminates an SfaNI endonuclease restriction site.
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
Nikoskelainen et al., Atlanta, United States. In Science, 1989
This mutation converted a highly conserved arginine to a histidine at codon 340 in the NADH dehydrogenase subunit 4 gene and eliminated an Sfa NI site, thus providing a simple diagnostic test.
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