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Solute carrier family 24

This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: HOX11L1, ROD, V1a, OUT, CAN
Papers on NCKX1
Anatomical evidence for a non-synaptic influence of the K(+)-dependent Na(+)/Ca(2+)-exchanger, NCKX2, on hippocampal plasticity.
Lytton et al., Calgary, Canada. In Neuroscience, Jan 2016
The K(+)-dependent Na(+)/Ca(2)-exchanger (NCKX) family is encoded by five related genes, of which NCKX2 (solute carrier family 24, member 2) is the most abundant member present in the brain.
Cation dependencies and turnover rates of the human K(+)-dependent Na(+)-Ca(2+) exchangers NCKX1, NCKX2, NCKX3 and NCKX4.
Schnetkamp et al., Calgary, Canada. In Cell Calcium, Dec 2015
UNASSIGNED: The Solute Carrier Family 24 (SLC24) belongs to the CaCA super family of Ca(2+)/cation antiporters and codes for five different K(+)- dependent Na(+)- Ca(2+) exchangers (NCKX1-5).
A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease.
Kefalov et al., Saint Louis, United States. In Hum Mol Genet, Nov 2015
It is thought that the concentration of Ca(2+) in rod outer segments is controlled by a dynamic balance between influx via cGMP-gated (CNG) channels and extrusion via Na(+)/Ca(2+), K(+) exchangers (NCKX1).
Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Lang et al., Tübingen, Germany. In Faseb J, May 2015
The augmented increase of [Ca(2+)]i could have been due to impaired Ca(2+) extrusion by K(+)-independent (NCX) and/or K(+)-dependent (NCKX) Na(+)/Ca(2+)-exchanger activity, which was thus determined from the increase of [Ca(2+)]i, (Δ[Ca(2+)]i), and current following abrupt replacement of Na(+) containing (130 mM) and Ca(2+) free (0 mM) extracellular perfusate by Na(+) free (0 mM) and Ca(2+) containing (2 mM) extracellular perfusate.
Elevated NCX1 and NCKX4 expression in the patent postnatal ductus arteriosus of ductal-dependent congenital heart disease patients.
Zhang et al., Shanghai, China. In Pediatr Cardiol, Apr 2015
The potassium-dependent Na(+)/Ca(2+) exchanger (NCKX) is a related family of NCX depending on the K(+) gradients which triggers DA constriction.
Impact of Na+/Ca2+ Exchangers on Therapy Resistance of Ovary Carcinoma Cells.
Lang et al., In Cell Physiol Biochem, 2014
Ca2+ signaling is further shaped by Ca2+ extrusion through K+-independent (NCX) and/or K+-dependent (NCKX) Na+/Ca2+-exchangers.
The membrane proteome of sensory cilia to the depth of olfactory receptors.
Warscheid et al., Bochum, Germany. In Mol Cell Proteomics, 2014
Moreover, we corroborated the ciliary localization of the potassium-dependent Na(+)/Ca(2+) exchanger (NCKX) 4 and the plasma membrane Ca(2+)-ATPase 1 (PMCA1) involved in olfactory signal termination, and we detected for the first time NCKX2 in olfactory cilia.
Recent structural and functional insights into the family of sodium calcium exchangers.
O'Halloran et al., Washington, D.C., United States. In Genesis, 2014
The Na(+) /Ca(2+) exchangers (NCX), Na(+) /Ca(2+) /K(+) exchangers (NCKX), and Ca(2+) /Cation exchangers (CCX) are the three classes of sodium calcium antiporters found in animals.
Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.
Lang et al., Tübingen, Germany. In Plos One, 2013
Factors affecting [Ca(2+)]i include Ca(2+)-release from intracellular stores (CRIS), store-operated Ca(2+)-entry (SOCE) through STIM1/STIM2-regulated Orai1, K(+)-dependent Na(+)/Ca(2+)-exchangers (NCKX), K(+)-independent Na(+)/Ca(2+)-exchangers (NCX) and calbindin-D28k.
The SLC24 family of K⁺-dependent Na⁺-Ca²⁺ exchangers: structure-function relationships.
Szerencsei et al., Calgary, Canada. In Curr Top Membr, 2013
Here, we focus on our current knowledge of NCKX transport function as has been described in detail only for in situ NCKX1 in the outer segments of retinal rod photoreceptors and on structure-function relationships elucidated for the NCKX2 isoform after expression of its (mutated) cDNA in cell lines.
Analysis of the Na+/Ca2+ exchanger gene family within the phylum Nematoda.
O'Halloran et al., Washington, D.C., United States. In Plos One, 2013
In animals, Na+/Ca2+ exchangers are divided into three groups based upon stoichiometry: Na+/Ca2+ exchangers (NCX), Na+/Ca2+/K+ exchangers (NCKX), and Ca2+/Cation exchangers (CCX).
The SLC24 gene family of Na⁺/Ca²⁺-K⁺ exchangers: from sight and smell to memory consolidation and skin pigmentation.
Schnetkamp, Calgary, Canada. In Mol Aspects Med, 2013
Members of the SLC24 gene family encode K(+)-dependent Na(+)/Ca(2+) exchangers (NCKX) that utilize both the inward Na(+) and outward K(+) gradients to extrude Ca(2+) from cells.
Expression and regulation of sodium/calcium exchangers, NCX and NCKX, in reproductive tissues: do they play a critical role in calcium transport for reproduction and development?
Jeung et al., Ch'ŏngju, South Korea. In Adv Exp Med Biol, 2012
Na(+)/Ca(2+) exchangers, NCX and NCKX, play a critical role in the transport of one [Ca(2+)](i) and potassium ion across the cell membrane in exchange for four extracellular sodium ions [Na(+)](e).
NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes.
Green et al., United Kingdom. In Adv Exp Med Biol, 2012
The nsSNP encodes the substitution of alanine for threonine at residue 111 (A111T) near a transmembrane region required for exchanger activity, a region which is highly conserved across different species and between NCKX family members.
A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness.
Hejtmancik et al., Lahore, Pakistan. In Am J Hum Genet, 2010
A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness.
Differential expression of Na/Ca exchanger and Na/Ca + K exchanger transcripts in rat brain.
Lytton et al., Calgary, Canada. In Ann N Y Acad Sci, 2002
Differential expression in the rat brain
Sodium/calcium exchange: its physiological implications.
Lederer et al., Baltimore, United States. In Physiol Rev, 1999
Five genes that code for the exchangers have been identified in mammals: three in the Na+/Ca2+ exchanger family (NCX1, NCX2, and NCX3) and two in the Na+/Ca2+ plus K+ family (NCKX1 and NCKX2).
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