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Nuclear autoantigenic sperm protein

NASP, histone H1-binding protein
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, H1, ACID, H4
Papers on NASP
Requirement for nuclear autoantigenic sperm protein mRNA expression in bovine preimplantation development.
Kawahara et al., Kōfu, Japan. In Anim Sci J, Jan 2016
UNASSIGNED: Nuclear autoantigenic sperm protein (NASP) is associated with DNA replication, cell proliferation, and cell cycle progression through its specific binding to histones.
Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B).
Marmorstein et al., Philadelphia, United States. In J Biol Chem, Jan 2016
Hat1 is predominantly localized in the nucleus as a member of a trimeric NuB4 complex containing Hat1, Hat2, and a histone H3-H4 specific histone chaperone called Hif1 (NASP).
Downregulation of tNASP inhibits proliferation through regulating cell cycle-related proteins and inactive ERK/MAPK signal pathway in renal cell carcinoma cells.
Wang et al., Nanjing, China. In Tumour Biol, Jul 2015
Nuclear auto-antigenic sperm protein (NASP), initially described as a highly auto-immunogenic testis and sperm-specific protein, is a histone chaperone that is proved to present in all dividing cells.
Histone chaperones in Arabidopsis and rice: genome-wide identification, phylogeny, architecture and transcriptional regulation.
Singla-Pareek et al., In Bmc Plant Biol, 2014
These could be classified into seven different families, namely NAP, CAF1, SPT6, ASF1, HIRA, NASP, and FACT.
Structural insights into yeast histone chaperone Hif1: a scaffold protein recruiting protein complexes to core histones.
Niu et al., In Biochem J, 2014
Yeast Hif1 [Hat1 (histone acetyltransferase 1)-interacting factor], a homologue of human NASP (nuclear autoantigenic sperm protein), is a histone chaperone that is involved in various protein complexes which modify histones during telomeric silencing and chromatin reassembly.
Peptides genetically selected for NF-κB activation cooperate with oncogene Ras and model carcinogenic role of inflammation.
Gudkov et al., Buffalo, United States. In Proc Natl Acad Sci U S A, 2014
Consistent with their ability to cooperate with oncogenic Ras in cell transformation, NASP expression reduced the transactivation activity of p53.
The influence of secondary structure, selection and recombination on rubella virus nucleotide substitution rate estimates.
Harkins et al., Cape Town, South Africa. In Virol J, 2013
We specifically accounted for possible confounders of nucleotide substitution rate estimates, such as temporally biased sampling, sporadic recombination, and natural selection favouring either increased or decreased genetic diversity (estimated by the PARRIS and FUBAR methods), at nucleotide sites within the genomic secondary structures (predicted by the NASP method).
Molecular evolution of NASP and conserved histone H3/H4 transport pathway.
Fillingham et al., Toronto, Canada. In Bmc Evol Biol, 2013
BACKGROUND: NASP is an essential protein in mammals that functions in histone transport pathways and maintenance of a soluble reservoir of histones H3/H4.
Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain.
Wirth et al., Köln, Germany. In Plos One, 2013
TRA2B has been shown to be involved in splicing processes of Nasp (nuclear autoantigenic sperm protein), MAPT (microtubule associated protein tau) and SMN (survival motor neuron), and is therefore implicated in spermatogenesis and neurological diseases like Alzheimer's disease, dementia, Parkinson's disease and spinal muscular atrophy.
Lysophosphatidic acid produced by hen egg white lysophospholipase D induces vascular development on extraembryonic membranes.
Tokumura et al., Tokushima, Japan. In Lipids, 2013
In an egg yolk angiogenesis assay, two lysoPtdOH receptor antagonists, Ki16425 and N-palmitoyl serine phosphoric acid (NASP), inhibited blood vessel formation induced by exogenously added 18:1-lysoPtdOH and its precursor lysoPtdCho on the hen yolk sac.
Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities.
Ausió et al., Victoria, Canada. In Faseb J, 2012
These include members of the nucleoplasmin (NPM2/NPM3), which are preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families.
MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).
Zhang et al., Shanghai, China. In J Biol Chem, 2012
an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.
The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms.
Parthun et al., Columbus, United States. In Nucleic Acids Res, 2012
sNASP interacts with linker and core histones through distinct structural domains.
A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain.
Almouzni et al., Paris, France. In Mol Cell, 2012
The insights into NASP function and the existence of a tunable reservoir in mammalian cells demonstrate that contingency is integrated into the histone supply chain to respond to unexpected changes in demand.
Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.
Elliott et al., Newcastle upon Tyne, United Kingdom. In Plos Genet, 2011
Regulated exons included a cassette exon which produces a meiotic isoform of the Nasp histone chaperone that helps monitor DNA double-strand breaks.
Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells.
O'Donnell et al., Australia. In Plos One, 2011
Loss of androgenic stimulus caused changes in proteins with known roles in meiosis (including Nasp and Hsp70-2), apoptosis (including Diablo), cell signalling (including 14-3-3 isoforms), oxidative stress, DNA repair, and RNA processing.
Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells.
O'Rand et al., Chapel Hill, United States. In Reprod Biol Endocrinol, 2010
tNASP is critical for the survival of prostate cancer cells; targeting tNASP expression can lead to a new approach for prostate cancer treatment.
Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP).
Kurumizaka et al., Tokyo, Japan. In J Biol Chem, 2010
A deletion analysis of sNASP revealed that the central region, amino acid residues 26-325, of sNASP is responsible for nucleosome assembly in vitro.
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